The effect of amyloride and procaine on expression of heat shock protein 70 in rat retina

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dc.contributor.authorTunç, M.
dc.contributor.authorGüven, A.
dc.contributor.authorCam, M.
dc.contributor.authorKaya, M.
dc.contributor.authorAktan, G.
dc.contributor.authorZiyal, İ
dc.date.accessioned2024-09-25T20:01:30Z
dc.date.available2024-09-25T20:01:30Z
dc.date.issued2002
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü en_US
dc.descriptionAnnual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology -- MAY 05-10, 2002 - Ft Lauderdale, FLen_US
dc.description.abstractTo identify the effects of amyloride and procaine in retinal expression of heat shock protein 70 (HSP 70) following traumatic injury. Methods: We induced traumatic stress by performing experimental spinal injury in 36 male Wistar-albino rats. We randomised the animals into three groups. Group I received no medications, Group II received intraperitoneal (IP) Procaine 15mg/kg, Group III received Amyloride 30 mg/kg IP. We sacrificed half of the animals in each groups at 12th hour and the remaining half in 24 hours. Following immidiate enucleation we isolated the retinae and detected HSP 70 immunoreactivity in each group. Results: There was moderate expression of HSP 70 in the outer nuclear and inner plexiform layer of the retinae after 12 hours and marked staining with HSP 70 antibodies 24 hours after the injury in all subjects which did not receive any medication. There was little or no immunoreaction to HSP 70 in rat retinae which received procaine or amyloride. Conclusion: Decreased expression of HSP 70 in the retina by procaine and amyloride indicates their neuroprotective role following traumatic stress.
dc.description.sponsorshipAssoc Res Vis & Ophthalmolen_US
dc.identifier.endpageU636en_US
dc.identifier.issn0146-0404
dc.identifier.issn1552-5783
dc.identifier.startpageU636en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/14160
dc.identifier.volume43en_US
dc.identifier.wosWOS:000184606602663en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherAssoc Research Vision Ophthalmology Incen_US
dc.relation.ispartofInvestigative Ophthalmology & Visual Scienceen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzYK_20240925en_US
dc.subjectNeuroprotective
dc.subjectAnimals
dc.subjectEnucleation
dc.subjectHSP
dc.titleThe effect of amyloride and procaine on expression of heat shock protein 70 in rat retinaen_US
dc.typeConference Objecten_US

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