Molecular and cellular mechanisms of aortic stenosis

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dc.contributor.authorYetkin, Ertan
dc.date.accessioned2021-06-23T19:26:31Z
dc.date.available2021-06-23T19:26:31Z
dc.date.issued2009
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractCalcific aortic stenosis is the most common cause of aortic valve replacement in developed countries, and this condition increases in prevalence with advancing age. The fibrotic thickening and calcification are common eventual endpoint in both non-rheumatic calcific and rheumatic aortic stenoses. New observations in human aortic valves support the hypothesis that degenerative valvular aortic stenosis is the result of active bone formation in the aortic valve, which may be mediated through a process of osteoblast-like differentiation in these tissues. Additionally histopathologic evidence suggests that early lesions in aortic valves are not just a disease process secondary to aging, but an active cellular process that follows the classical “response to injury hypothesis” similar to the situation in atherosclerosis. Although there are similarities with the risk factor and as well as with the process of atherogenesis, not all the patients with coronary artery disease or atherosclerosis have calcific aortic stenosis. This review mainly focuses on the potential vascular and molecular mechanisms involved in the pathogenesis of aortic valve stenosis. Namely extracellular matrix remodeling, angiogenesis, inflammation, and eventually osteoblast-like differentiation resulting in bone formation have been shown to play a role in the pathogenesis of calcific aortic stenosis. Several mediators related to underlying mechanisms, including growth factors especially transforming growth factor-β1 and vascular endothelial growth factors, angiogenesis, cathepsin enzymes, adhesion molecules, bone regulatory proteins and matrix metalloproteinases have been demonstrated, however the target to be attacked is not defined yet.en_US
dc.identifier.endpageS50en_US
dc.identifier.issn1107-3756
dc.identifier.startpageS50en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/6570
dc.identifier.urihttps://doi.org/10.1016/j.ijcard.2009.03.108
dc.identifier.volume24en_US
dc.identifier.wosWOS:000270497500185en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.institutionauthorYetkin, Ertan
dc.language.isoenen_US
dc.publisherSpandidos Publ Ltden_US
dc.relation.ispartofInternational Journal Of Molecular Medicineen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAortic Valveen_US
dc.subjectCalcification
dc.subjectGrowth Factors
dc.subjectStatin
dc.subjectAngiogenesis
dc.titleMolecular and cellular mechanisms of aortic stenosisen_US
dc.typeConference Objecten_US

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