Serum total and HDL-phospholipid levels in a population based study and relation to risk of metabolic yndrome and coronary disease

Basit Öğe Kaydı
dc.authorid0000-0001-5815-6700
dc.contributor.authorHergenç, Gülay
dc.contributor.authorOnat, Altan
dc.contributor.authorYazıcı, Mehmet
dc.contributor.authorSarı, İbrahim
dc.contributor.authorCan, Günay
dc.date.accessioned2024-09-25T20:01:29Z
dc.date.available2024-09-25T20:01:29Z
dc.date.issued2006
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü en_US
dc.description14th Meeting of the International-Society-of-Atherosclerosis -- JUN 18-22, 2006 - Rome, ITALYen_US
dc.description.abstractThe aim of study was to investigate the role of serum total (TPL) and high-density lipoprotein phospholipids (HDL-pl) as a risk factor in coronary heart disease (CHD) and metabolic syndrome (MS). In a random sample, total and HDL-pl were measured in 1088 and 642 adults from Turkey, respectively, who have a high prevalence of MS; this was done with an enzymatic method that measures total phosphatidylcholine, sphingomyelin, and lysophosphatidylcholine. Serum TPL and HDL-pl levels were significantly higher in women (TPL, 2.8 mmol/L; HDL-pl, 1.21 mmol/L) than in men. Strong correlations existed between serum TPL levels and nonHDL cholesterol (HDL-C), triglycerides, apolipoprotein (apo) B, complement C3, and γ-glutamyltransferase. Non–HDL-C, HDL triglyceride, and apo A-I were strongly correlated with HDL-pl. Linear regression analyses revealed HDL-C, apo B, triglycerides, diabetes, and female gender as independent significant determinants of TPL levels in adults. HDL-C and impaired glucose regulation were sole significant variables, together contributing one-quarter of serum HDL-pl. Individuals with MS or diabetes had significantly higher TPL concentrations. The gender- and age-adjusted odds ratio (OR) of TPL for MS was 1.73 (95% confidence interval, 1.35-2.21), whereas the multiadjusted OR of HDL-pl per 1 SD increment corresponded to a significantly reduced independent MS likelihood by 26% in women (and 18% in the entire group). The multiadjusted OR of HDL-pl for CHD in men and women combined was 0.32 (P = .057) corresponding to a reduced CHD likelihood by 32% per 1 SD increment of HDL-pl. Plasma TPL levels point to an adverse relationship to MS, whereas their role in CHD risk needs further investigation. HDL-pls, in contrast, mark substantial protection from MS as well as from CHD.
dc.description.sponsorshipInt Soc Atherosclerosen_US
dc.identifier.doi10.1016/S1567-5688(06)80178-9
dc.identifier.endpage55en_US
dc.identifier.issn1567-5688
dc.identifier.issue3en_US
dc.identifier.startpage55en_US
dc.identifier.urihttps://doi.org/10.1016/S1567-5688(06)80178-9
dc.identifier.urihttps://hdl.handle.net/20.500.12491/14141
dc.identifier.volume7en_US
dc.identifier.wosWOS:000239093900179en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofAtherosclerosis Supplementsen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzYK_20240925en_US
dc.subjectPhospholipids
dc.subjectPopulation-Based Study
dc.subjectCoronary Heart Disease
dc.subjectMetabolic Syndrome
dc.titleSerum total and HDL-phospholipid levels in a population based study and relation to risk of metabolic yndrome and coronary diseaseen_US
dc.typeConference Objecten_US

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