Molecularly Imprinted Quartz Crystal Microbalance Sensor (QCM) for Bilirubin Detection

Basit Öğe Kaydı
dc.authorid0000-0003-3260-1639
dc.contributor.authorÇicek, Çiğdem
dc.contributor.authorYılmaz, Fatma
dc.contributor.authorÖzgür, Erdoğan
dc.contributor.authorYavuz, Handan
dc.contributor.authorDenizli, Adil
dc.date.accessioned2021-06-23T19:42:46Z
dc.date.available2021-06-23T19:42:46Z
dc.date.issued2016
dc.departmentBAİBÜ, Gerede Meslek Yüksekokulu, Kimya Ve Kimyasal İşleme Teknolojileri Bölümüen_US
dc.description.abstractThis study aims the preparation of a QCM sensor for the detection of bilirubin in human plasma. Bilirubin-imprinted poly-(2-hydroxyethyl methacrylate-N-methacryloyl-l-tryptophan methyl ester) (PHEMATrp) nanofilm (MIP) on the gold surface of a QCM chip was synthesized by the molecular imprinting technique. Meanwhile, the non-imprinted PHEMATrp (NIP) nanofilm was synthesized by the same experimental technique to examine the imprinting effect. Characterization of MIP and NIP nanofilms on the QCM chip surface was achieved by atomic force microscopy (AFM), ellipsometry, Fourier transform infrared spectrophotometry-attenuated total reflectance (FTIR-ATR) and contact angle measurements (CA). The observations indicated that the nanofilm was almost in a monolayer. Thereinafter, the imprinted and the non-imprinted QCM chips were connected to the QCM system to investigate kinetic and affinity properties. In order to examine the selectivity of the MIP-PHEMATrp nanofilm, competitive adsorption of bilirubin with cholesterol and estradiol was performed. Limit of detection (LOD) and limit of quantitation (LOQ) values were calculated as 0.45 g/mL and 0.9 g/mL, respectively.en_US
dc.identifier.doi10.3390/chemosensors4040021
dc.identifier.issn2227-9040
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85016632101en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.3390/chemosensors4040021
dc.identifier.urihttps://hdl.handle.net/20.500.12491/8599
dc.identifier.volume4en_US
dc.identifier.wosWOS:000392275300001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorYılmaz, Fatma
dc.language.isoenen_US
dc.publisherMdpi Agen_US
dc.relation.ispartofChemosensorsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMolecular Imprinting Techniqueen_US
dc.subjectBilirubinen_US
dc.subjectQCMen_US
dc.subjectPHEMAen_US
dc.subjectNanosensoren_US
dc.titleMolecularly Imprinted Quartz Crystal Microbalance Sensor (QCM) for Bilirubin Detectionen_US
dc.typeArticleen_US

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