Factors affecting pognosis and mortality in severe Covid-19 pneumonia patients

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dc.authorid0000-0002-2450-6378en_US
dc.authorid0000-0001-6262-6103en_US
dc.contributor.authorAfşin, Emine
dc.contributor.authorDemirkol, Muhammed Emin
dc.date.accessioned2024-04-30T11:01:16Z
dc.date.available2024-04-30T11:01:16Z
dc.date.issued2023en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractFatality rate in coronavirus disease 2019 (COVID-19) cases has been reported to be 3.4% worldwide. The aim of this study was to evaluate the factors that determine prognosis and mortality in severe COVID-19 pneumonia patients. Eighty adult patients with severe COVID-19 pneumonia vember 2020 were included in this retrospective single-center study. Demographic and laboratory data, severity of radiological involvement, comorbidities, agents used in treatment, and clinical results were recorded, and data were grouped as survivors and non-survivors. The mean patient age was 67.8 +/- 12.6 years. There were 59 (73.8%) male patients. Comorbid diseases were present in 53 (66.3%) patients. There was no significant relationship between patient age, gender, smoking status or presence of comorbidity and mortality (p>0.05). The variables such as pulmonary involvement above 50%, intubation, or ferritin (>434.8 mu g/L), troponin I (>14.05 ng/L) and procalcitonin (>0.125 ng/mL) as the sole variables of laboratory data were found to have significant relationship with increased mortality (p<0.05). Mortality was significantly higher in patients using steroid pulse therapy + tocilizumab, steroid pulse therapy + hydroxychloroquine, or solely steroid pulse therapy, while it was significantly lower in patients receiving azithromycin therapy and those in the plasma + steroid pulse therapy group. The severity of pulmonary involvement, intubation, and increase in inflammation markers such as ferritin, troponin and procalcitonin were found to be significantly associated with mortality (p<0.05). Treatment approaches with azithromycin and plasma + steroid pulse therapy were found to reduce mortality.en_US
dc.identifier.citationAfşin, E., & Demirkol, M. E. (2023). Factors Affecting Prognosis and Mortality in Severe COVID-19 Pneumonia Patients. Acta Clinica Croatica, 62(1), 106-114.en_US
dc.identifier.doi10.20471/acc.2023.62.01.13
dc.identifier.endpage114en_US
dc.identifier.issn0353-9466
dc.identifier.issn1333-9451
dc.identifier.issue1en_US
dc.identifier.pmid#YOKen_US
dc.identifier.startpage106en_US
dc.identifier.urihttp://dx.doi.org/10.20471/acc.2023.62.01.13
dc.identifier.urihttps://hdl.handle.net/20.500.12491/12114
dc.identifier.volume62en_US
dc.identifier.wosWOS:001054807700013en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.institutionauthorAfşin, Emine
dc.institutionauthorDemirkol, Muhammed Emin
dc.language.isoenen_US
dc.publisherSestre milosrdnice University Hospitalen_US
dc.relation.ispartofActa Clinica Croaticaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCOVID-19en_US
dc.subjectPneumoniaen_US
dc.subjectPrognosisen_US
dc.subjectMortalityen_US
dc.titleFactors affecting pognosis and mortality in severe Covid-19 pneumonia patientsen_US
dc.typeArticleen_US

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