Bilinmeyen Klinik Yönleri ile Lyme Hastalığı: Yedi Olgunun Gözden Geçirilmesi
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Dosyalar
Tarih
2015
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Galenos Yayncılık
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Giriş: Lyme hastalığı (LH), genellike enfekte kenelerin ısırması ile bulaşan ve Borrelia burgdorferi bakterisinin neden olduğu bir hastalıktır. LH, birçok
organ veya sistemi tutarak geniş bir klinik tablo oluşturur. Bu hastalık tipik olarak deri, sinir, kas-iskelet ve kalbi tutar. Öyküsünde kene ısırması olan
ve tipik bulgu gösteren hastalarda B. burgdorferi antikorlarının pozitifliği, hastalığın tanı ve tedavisinin temelini oluşturur. Antibiyotikler olguların
çoğunu iyileştirir. Erken ve hızlı tedavi tamamen düzelme sağlayabilir. Bu yazıda farklı klinik tablo gösteren yedi Li H olgusu sunulmaktadır. Bu
sunumdaki amaç LH’nin klinik semptomlarını, tanı ve tedavisini güncel bilgiler ışığında özetlemektir.
Gereç ve Yöntem: Son beş yılda hastanemize başvuran, serolojik ve klinik olarak doğrulanan yedi LH olgusu sunuldu. Klinik olarak, LH’nin değişik
evrelerini düşündüren, dolaylı enzime-bağlı bağışıklık deneyi yöntemiyle (ELISA) B. burgdorferi immünglobulin G ve immünglobulin M antikorları
olumlu olan hastalar, değerlendirmeye alındı.
Bulgular: Yaşları 19-64 arasında değişen dört kadın, üç erkekte, değişik klinik tablolarda LH saptandı. Bir olgu erken lokalize LH (eritema migrans),
beş olgu erken yaygın ve bir olgu da geç yaygın LH olarak tanımlandı. Hastalar uygun antibiyotiklerle tedavi edildi.
Sonuç: LH her tip klinik tabloyu taklit edebilen, tanısı seroloji ile konabilen, ciddi bir zoonotik hastalıktır. Kene ile temas öyküsü olan ve değişik klinik
tablolarda gelen hastalarda LH düşünülmesi ve tetkiklerin yapılması aynı zamanda uygun antibiyoterapi ile tedavi edilmesi gerekir.
Anahtar kelimeler: Lyme hastalığı, tanı, tedavi, Borrelia burgdorferi, klinik bulgular, Türkiye
Introduction: Lyme disease (LD), caused by the bacterium Borrelia burgdorferi, is mostly caused by bites of infected ticks. LD can affect multiple body systems or organs, and produce a broad range of symptoms. It typically involves the skin, nervous system, musculoskeletal system and the heart. A history of confirmed exposure to tick bites, in the patients who had typical signs and symptoms of Lyme borreliosis and positive antibody tests for B. burgdorferi antibodies are basis of the diagnosis. The treatment of LD is determined mainly by the clinical manifestations of the disease. Antibiotics may cure most cases of LD. The early and quick therapy may provide complete recovery. In this paper, seven patients with LD who had different clinical pictures are presented. The aim of this review was to summarize current knowledge of the symptoms, clinical diagnosis and treatment of Lyme borreliosis. Materials and Methods: Seven patients with clinically and serologically confirmed LD who were admitted to our hospital in the past five years are presented. The patients clinically suggesting LD and whose serum specimens were positive for B. burgdorferi immunoglobulin G and immunoglobulin M antibodies by enzyme-linked immunosorbent assay (ELISA) were evaluated. Results: Four female and three male patients aged 19-64 years, were found to have LD with different clinical conditions. One patient had early localized LD (Erythema migrans), one had late disseminated LD, and five patients had early disseminated LD. The patients were treated with appropriate antibiotics. Conclusion: LD is a serious zoonotic disease mimicking all types of clinical presentation that may be diagnosed serologically. LD should be kept in mind in patients with a history of tick bite and presenting with different clinical findings. Appropriate antibiotic treatment should be initiated after serological investigations.
Introduction: Lyme disease (LD), caused by the bacterium Borrelia burgdorferi, is mostly caused by bites of infected ticks. LD can affect multiple body systems or organs, and produce a broad range of symptoms. It typically involves the skin, nervous system, musculoskeletal system and the heart. A history of confirmed exposure to tick bites, in the patients who had typical signs and symptoms of Lyme borreliosis and positive antibody tests for B. burgdorferi antibodies are basis of the diagnosis. The treatment of LD is determined mainly by the clinical manifestations of the disease. Antibiotics may cure most cases of LD. The early and quick therapy may provide complete recovery. In this paper, seven patients with LD who had different clinical pictures are presented. The aim of this review was to summarize current knowledge of the symptoms, clinical diagnosis and treatment of Lyme borreliosis. Materials and Methods: Seven patients with clinically and serologically confirmed LD who were admitted to our hospital in the past five years are presented. The patients clinically suggesting LD and whose serum specimens were positive for B. burgdorferi immunoglobulin G and immunoglobulin M antibodies by enzyme-linked immunosorbent assay (ELISA) were evaluated. Results: Four female and three male patients aged 19-64 years, were found to have LD with different clinical conditions. One patient had early localized LD (Erythema migrans), one had late disseminated LD, and five patients had early disseminated LD. The patients were treated with appropriate antibiotics. Conclusion: LD is a serious zoonotic disease mimicking all types of clinical presentation that may be diagnosed serologically. LD should be kept in mind in patients with a history of tick bite and presenting with different clinical findings. Appropriate antibiotic treatment should be initiated after serological investigations.
Açıklama
Anahtar Kelimeler
Lyme Disease, Diagnosis, Therapy, Borrelia Burgdorferi, Clinical Findings, Turkey
Kaynak
Mediterranean Journal Of Infection Microbes And Antimicrobials
WoS Q Değeri
N/A
Scopus Q Değeri
Cilt
4
