The effects of combined vitamin C and vitamin E in streptozotocin-induced diabetic rat kidney

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dc.authorid0000-0003-1364-4684
dc.authorid0000-0002-9313-2920
dc.authorid0000-0002-8317-7092
dc.contributor.authorKükner, Aysel
dc.contributor.authorÇolakoğlu, Neriman
dc.contributor.authorÖzoğlu, Candan
dc.contributor.authorNaziroğlu, Mustafa
dc.contributor.authorFırat, Tülin
dc.date.accessioned2021-06-23T18:52:04Z
dc.date.available2021-06-23T18:52:04Z
dc.date.issued2009
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractDiabetic nephropathy is a serious complication of diabetes mellitus. Oxidative stress has been suggested to play a key role in the pathogenesis of diabetic nephropathy. Vitamins C and E play important roles in the antioxidant defense system. It is likely that both vitamins act in a synergistic manner, with vitamin E primarily being oxidized to the tocopheroxyl radical and then reduced back to tocopherol by vitamin C. The purpose of the study was to determine the effects of supplementation of Vitamins C and E (VCE) on diabetic rat kidney. Adult female Wistar rats were used in the study. The animals were divided into three groups. Group I: the control group; Group II: diabetic group, streptozotocin (40 mg kg-1) was administered group; Group III: diabetes + VCE group, received a diet containing a combination of ascorbic acid and dl-?-tocopheryl acetate per kg of feed. Rats were killed on 21st day and renal tissues were taken and fixed in 2.5% glutaraldehyde solution for electron microscopic examination. When compared with the control group, congestion of the glomerular capillaries, increased mesangial cells and distinct mesangium, shortened podocyte processes and disappearance of filtration slit pore of diabetic rat kidney were observed. In the group treated with VCE, glomerular changes were less distinct than the diabetic group. Lengths of the pedicles were similar to the control group. VCE reduced the changes in the glomerular structures due to diabetes. © Medwell Journals, 2009.en_US
dc.identifier.endpage220en_US
dc.identifier.issn1815-9346
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-77953455060en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage214en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/4116
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-77953455060&partnerID=40&md5=245163a96d699f230346b98306c7869a
dc.identifier.volume3en_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorKükner, Aysel
dc.institutionauthorFırat, Tülin
dc.language.isoenen_US
dc.relation.ispartofResearch Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiabetesen_US
dc.subjectKidneyen_US
dc.subjectOxidizeden_US
dc.subjectRenalen_US
dc.subjectTissueen_US
dc.subjectUltrastructureen_US
dc.subjectVitamin C and Een_US
dc.titleThe effects of combined vitamin C and vitamin E in streptozotocin-induced diabetic rat kidneyen_US
dc.typeArticleen_US

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