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Öğe Clinical evaluation and classification of patients with temporomandibular disorders using ‘Diagnostic Criteria for Temporomandibular Disorders(2020) Alpaslan, Cansu; Yaman, DenizOBJECTIVE: The aim of the study was to evaluate the frequency of subgroups in a clinical setting of the patientswith temporomandibular disorders (TMD) using ‘Diagnostic Criteria for Temporomandibular Disorders (DC/TMD)’.MATERIALS AND METHOD: A total of 128 patients with TMD(92 females and 36 males, mean age 33.5 ± 8.28) were involved in the study. DC/TMD Axis I diagnosis criteria wasused for the clinical examination of pain disorders andtemporomandibular joint (TMJ) disorders. Also, in DC/TMD Axis I, The TMD Pain Screener, focusing on painwithin the last 30 days, was used. In DC/TMD Axis II evaluation, the Jaw Functional Limitation Scale-8 (JFLS-8) waspreferred to detect symptom severity and functional limitations. The data analysis was conducted by using theChi-square, Kruskal Wallis test, and the Bonferroni correction for the Mann-Whitney U test.RESULTS: Out of 128 patients, 120 patients (93.75%) hadTMJ disorders that were accompanied by muscle pain disorders. The effect of gender and age on TMJ/muscle paindisorders was not significant (TMJ disorders; p=0.123,p=0.263; Muscle pain disorders; p=0.145, p=0.100, respectively). According to JFLS-8, the limitation in mastication(item 1 and 2) and joint mobility (item 4) were major complaints in the group of patients with ‘disc displacementwithout reduction with limited opening’ compared to theother TMJ disorders (p=0.001, p=0.004, p=0.007, p<0.008).CONCLUSION: DC/TMD Axis I is a significant reference toclinicians in the diagnosis and evaluation of TMD. In DC/TMD Axis II, JFLS-8 is an efficient instrument for the measurement of functional limitation associated with temporomandibular disorders.Öğe Correlation of molecular biomarker concentrations between synovial fluid and saliva of the patients with temporomandibular disorders(Springer Heidelberg, 2020) Yaman, Deniz; Alpaslan, Cansu; Akça, Gülçin; Avcı, EmreObjectives The synovial membrane and fluid are involved in the pathogenesis of temporomandibular joint (TMJ) disorders. This study aims to assess the relationship between matrix metalloproteinase-2 (MMP-2), chemerin and prostaglandin (PGE(2)) levels in the synovial fluid (SF) and saliva of patients with TMJ disorder regarding their role in inflammation and the value of being a candidate for predictive biomarkers in the disease. Also, it is aimed to find out whether chemerin's main function triggers the formation inflammatory cytokine markers in the associated area. Materials and methods Thirty-two samples of SF and saliva were obtained from patients with disc displacement without reduction with limited opening (DDWORwLO). Mann-Whitney-U test was used for the comparisons of the biomarker levels in SF and saliva. The correlation between chemerin and BMI (Body Mass Index) is analyzed by non-parametric Spearman's rho correlation coefficient. Results For all of the three biomarkers, statistically significant differences were found between SF and saliva. An unexpectedly high level expression of chemerin was observed in SF. A statistically significant, positive correlation was observed between PGE(2) -MMP-2, and chemerin-PGE(2) in saliva, chemerin and MMP-2 in SF, respectively (p = 0.031, r = 0.382 / p = 0.039, r = 0.366 / p = 0.032, r = 0.379). A positive correlation was determined between saliva and SF levels of PGE(2) (p = 0.016, r = 0.421). Conclusions Chemerin, MMP-2, and PGE(2) can play a role as an inflammatory factor for the development of TMJ disorder.Öğe Dental and temporomandibular joint alterations in rheumatoid arthritis patients and their association with salivary oxidative stress(TUBITAK Scientific & Technical Research Council Turkey, 2021) Yaman, Deniz; Bulut, Duygu Göller; Ustaoğlu, Gülbahar; Avcı, Emre; Taşçı, MuratBackground/aim: Rheumatoid arthritis (RA) is the most extensive inflammatory arthritis causing permanent deformities in the joint. Increasing evidence suggests that oxidative stress is a substantial factor in the pathogenesis of RA. This study aimed to examine the salivary oxidant-antioxidant status of RA and control groups and to compare these biomarkers by correlating them with disease activity, acute phase reactants, and clinical findings. Materials and methods: Age and sex-matched 60 participants including 30 patients with RA and 30 control (50 females, 10 males; mean age: 42.62 +/- 10.89 years) were evaluated. RA disease activity and severity were evaluated by the disease activity score 28-C reactive protein (DAS 28-CRP). Rheumatoid factor (RF) positivity, anticitrullinated protein antibodies (ACPA) positivity, erythrocyte sedimentation rate (ESR), CRP, tender and swollen joint counts, and medical treatment regimens of the patients (glucocorticoids, conventional or biologic disease-modifying antirheumatic drugs) were recorded. In the radiographic examination, dental findings, and bone alterations of the temporomandibular joint (TMJ) were recorded and compared for both groups. Saliva samples were obtained for analysis of total antioxidant status (TAS), total oxidant status (TOS), arylesterase (ARE), and oxidative stress index (OSI) levels. The data analysis was conducted by independent sample t-test and chi-square test. Results: Condylar erosion was the most common radiographic change in TMJ of RA patients. Osteophyte formation was a prominent finding in the control group. Lower TAS and higher OSI levels were found in RA patients compared with controls (p = 0.013; p = 0.029, respectively). The effect of DAS 28-CRP score on the levels of oxidative stress biomarkers in RA patients was not significant. Conclusion: Oxidative stress causes tissue damage in response to excessive mechanical loading, which in turn promotes TMD. However, disease activity has not a prominent impact on the salivary oxidative stress status of RA patients.Öğe The effects of Biofreeze and superficial heat on masticatory myofascial pain syndrome(Istanbul Univ Press, Istanbul Uiıv Rectorate, 2021) Yaman, Deniz; Alpaslan, Cansu; Kalaycıoğlu, OyaPurpose This study aims to assess the influence of superficial heat and Biofreeze on pain, mouth opening (mm), and quality of life in patients with masticatory myofascial pain syndrome (MPS). Materials and Methods 52 patients with MPS were included in the study. They were randomly divided into two groups. Patients in the Biofreeze group (n = 26) applied 3.5% menthol gel to the masseter and temporal muscles twice a day for seven days, while the other group applied superficial heat. Baseline, 7th, and 21st days of VAS, mouth opening (mm), and Oral Health Impact Profile-14 (OHIP-14) scores of the patients were evaluated statistically. Results The mouth opening increased by 4.27 +/- 3.80 mm in the Biofreeze group and 2.58 +/- 2.16 mm in the superficial heat group. In each group, a significant decrease in VAS and OHIP-14 scores was observed on the 7th day compared to the baseline values (p<0.001). There was no statistically significant difference between the two applications on myofascial pain, mouth opening (mm), and OHIP-14 total score variables. The favorable effects of both applications on these parameters were limited to the duration of use. Conclusion Biofreeze and superficial heat in MPS were found to increase the quality of life, but the limited effectiveness of these applications underlines the importance of the underlying factors.Öğe Evaluation of bacterial colonization and clinical properties of different suture materials in dentoalveoler surgery(W B Saunders Co-Elseiver Inc, 2022) Yaman, Deniz; Paksoy, Tuğçe; Ustaoğlu, Gülbahar; Demirci, MehmetPurpose: This study aimed to compare the effects of 10 different suture materials commonly used in dentoalveolar surgery on wound healing, their postoperative microbial colonization, and related clinical parameters. Methods: A total of 172 suture samples from patients who had undergone extraction of impacted third molars were included in the study. The suture materials studied were poly-glycolide-colactide, fast absorbable poly-glycolide-colactide, poly-glycolic acid-cocaprolactone, polydioxanone, silk, polypropylene, polyvinylidene difluoride, polyamide, polyester, and polytetrafluoroethylene (PTFE). The microbial colonization in all sutures and clinical parameters were evaluated after 1 week. Results: Multifilament sutures had higher bacterial colonization compared with monofilament sutures (P < .001). No dental plaque accumulation was observed in any samples of polypropylene sutures. Polydioxanone, PTFE, and poly-glycolic acid-cocaprolactone sutures exhibited less postoperative slack compared with all other sutures after 1 week. Patients with silk, polyvinylidene difluoride, and PTFE sutures had less suture-related discomfort. According to the Landry index score, monofilament sutures demonstrated superior wound healing to multifilament sutures (P = .019). In addition, nonabsorbable sutures showed significantly better wound epithelization than absorbable sutures (P < .001). Conclusions: Bacterial colonization and tissue reactions due to the surface properties of the suture affected the wound healing after dentoalveolar surgery. Multifilament sutures should not be applied for prolonged periods because of their tendency for microbial colonization. The tissue reaction to the absorbable suture materials may adversely affect wound healing. (C) 2021 The American Association of Oral and Maxillofacial Surgeons.Öğe Evaluation of the relationship of dimensions of maxillary sinus drainage system with anatomical variations and sinusopathy: Cone-Beam computed tomography findings(Karger, 2020) Akay, Gülsün; Yaman, Deniz; Karadağ, Özge; Güngör, KahramanObjective: The aim of this study was to evaluate the correlation between the length of the infundibulum and ostium height with the anatomic variations of osteomeatal complex (OMC) and sinus pathology using cone-beam computed tomography (CBCT). Methods: CBCT images of 204 patients (408 maxillary sinuses) were evaluated retrospectively. The height of the ostium and the length of the infundibulum were measured. The presence of maxillary sinus pathology, nasal septal deviation, Haller cells, concha bullosa, and sinus septa were analyzed. The correlation between the size of the maxillary sinus drainage system and anatomic variations was compared using the t test, Fisher's exact test, and chi (2) test. The effect of tooth loss on the length of the infundibulum and ostium height was also analyzed using ANOVA. Results: The height of the ostium and the maximal septal deviation angle were found to be significantly greater in males (p < 0.05). As ostium height increased, the presence of maxillary sinus septa increased (p < 0.05). No statistically significant association was detected between other variations and the length of infundibulum or ostium height. The relationship between tooth loss and both the length of the infundibulum and ostium height were found to be insignificant (p > 0.05). Conclusions: Radiographic examination, especially on CBCT images, is important for an evaluation of maxillary sinuses. here, we demonstrated a significant relationship between ostium height and the presence of maxillary sinus septa. However, it was found that nasal septal deviation, concha bullosa, Haller cells, and other sinusopathies did not have a major effect on the size of the maxillary sinus drainage system.Öğe Investigation of asymptomatic temporomandibular disorders with Fonseca anamnestic index in clinical practice(2021) Yaman, Deniz; Alpaslan, Cansu; Kalaycıoğlu, OyaObjective: The study aims to evaluate the presence of temporomandibular disorders (TMD) and their severity in asymptomatic and healthy individuals using the Fonseca anamnestic index.Materials and Method: A total of 135 individuals (80 females and 55 males, mean age 34.4±10.9) were involved in the study. The Fonseca anamnestic index was administered to the individuals. The data analysis was conducted by using Pearson's chi-squared test, Fisher's exact test, one-way ANOVA, and Spearman’s correlation.Results: TMD was detected in 63% of the individuals. Most of them (40%) had mild TMD. The difference between gender and TMD severity was statistically significant (p=0.001). Temporomandibular joint (TMJ) pain showed a statistically significant positive correlation with headache and emotional stress (r=0.312, p?0.001; r=0.299, p?0.001, respectively). TMJ pain showed the strongest positive correlation with clicking (r=0.443, p?0.001). Bruxism showed positive correlations with the TMJ pain and clicking (r=0.197, p=0.022 and r= 0.221, p=0.010, respectively).Conclusion: The Fonseca anamnestic index is a reliable diagnostic tool that can be used to detect TMD-related symptoms and severity even in asymptomatic and healthy participants, providing rapid results in clinical practice.Öğe The link between total antioxidant status, total oxidant status, arylesterase activity, and subgingival microbiota in psoriasis patients(Wiley, 2022) Paksoy, Tuğçe; Ustaoğlu, Gülbahar; Yaman, Deniz; Arıöz, Özkan; Demirci, Mehmet; Polat, MuallaBackground Studies focusing on the relationship between periodontitis and systemic diseases have suggested a possible association between these two chronic and inflammatory disorders. We aimed to comparatively investigate the salivary oxidative status, biomarker levels, clinical findings, and the microbial load on subgingival biofilm samples in psoriasis patients and controls. Methods Forty participants were allocated into four groups as follows: (1) systemically and periodontally healthy (C group); (2) systemically healthy with periodontitis (P group); (3) psoriasis (Ps) and periodontally healthy (Ps-C group); and (4) Ps with periodontitis (Ps-P group). Subgingival biofilm samples were obtained to detect the periodontopathogenic agents by Real-time PCR (qPCR). The total antioxidant status (TAS) (mmol/l), total oxidant status (TOS) (mu mol/l), and arylesterase (ARE) activity (U/L) were analyzed using saliva samples. Results The level of TOS and oxidative stress index (OSI) were significantly higher in patients with Ps-P and P compared to controls (P = 0.001, and P < 0.001, respectively). ARE levels were higher in controls compared to Ps and P (P < 0.001). The prevalences of bacteria detected in subgingival biofilm samples were similar between all groups (P > 0.05). Conclusions This study reported that psoriasis may amplify TOS and OSI, and the co-existence of psoriasis and periodontitis may aggravate oxidative stress.Öğe MULTIPLE DENTIGEROUS CYSTS WITH RADIOLOGICAL FINDINGS IN A NONSYNDROMIC PATIENT(2020) Yaman, Deniz; Akay, Gülsün; Güngör, KahramanDentigerous cyst is the most common odontogenic cyst of the jaws after radicular cyst and is usually observed as unilateral involvement. The multiple involvement of this cyst is rather rare if not accompanied of an underlying systemic disease or syndrome. In this report, radiographic findings and surgical treatment of a patient with non-syndromic multiple dentigerous cyst, who applied to the clinic for prosthetic treatment were presented. Panoramic radiograph revealed radiolucencies associated with the crowns of bilateral mandibular third molar teeth, right maxillary third molar, bilateral maxillary canines. In cone-beam computed tomography (CBCT), it was revealed as well?defined unilocular radiolucent areas surrounded by sclerotic border and related to the crown of the unerupted teeth. In intermittent sessions, multiple dentigerous cysts were enucleated and the associated impacted teeth were extracted under local anesthesia. According to the comprehensive research, this is the first case-report presenting the surgical treatment and revealing the radiographic findings in elderly non-syndromic patient with multiple dentigerous cyst in maxilla and mandible.Öğe Oxidative stress and peri-implantitis: The role of oxidants and antioxidants(Kerman University of Medical Sciences, 2023) Yaman, Deniz; Ustaoğlu, Gülbahar; Avcı, EmreBackground: Peri-implantitis is the main cause of implant failure and is associated with augmented oxidative stress or tissue destruction. In this study, it was aimed to investigate the oxidant-antioxidant balance parameters in individuals with periimplantitis, considering the clinical findings and the control group.Methods: Peri-implantitis (n = 30) and healthy (n = 30) individuals participated in the study. Peri-implant clinical parameters, including probing depth (PD), gingival index (GI), plaque index (PI), bleeding on probing (BoP), and keratinized mucosa width (KMW), were recorded. The levels of total antioxidant capacity (TAC), total oxidant capacity (TOC), oxidative stress index (OSI), and arylesterase (ARE) in saliva were examined. To identify the relationship between oxidative stress biomarkers and clinical parameters was used Spearman's correlation coefficient. Results: TOC values were higher in peri-implantitis, and they correlated with BoP, GI, PD, and PI (P= 0.004, r= 0.370; P= 0.010, r= 0.328; P= 0.038, r= 0.268; P= 0.007, r = 0.342, respectively). TAC values were higher in healthy and correlated with PI, BoP, and GI (P= 0.021, r =-0.297; P= 0.035, r =-0.273; P= 0.012, r =-0.321, respectively). OSI showed a negative correlation with the KMW (mm) (P= 0.046, r =-0.259).Conclusion: Increased TOC and decreased TAC and ARE activity could be predictors of peri-implantitis development. Adequate KMW is important in the production of antioxidants.Öğe PHYSIOLOGICAL EFFECTS OF IMPACTED MESIODENS ON THE DEVELOPMENT OF ADJACENT TEETH(2024) Yar, Merve; Türker, Nurşat; Bulut, Duygu Göller; Yaman, DenizIn the present retrospective study, it was aimed to analyze the physiological effects of impacted mesiodens on adjacent teeth with dental and chronological age determination in cone beam computed tomography (CBCT). In the study, 68 CBCT images were examined. Two groups were formed, including 34 individuals with mesiodens (mesiodens group) and 34 without mesiodens (control group).Dental age and chronological age were compared in both groups. Demirjian's method was utilized to determine the dental age. The position and location of mesiodens were categorized. Statistical analysis was performed withSPSS software version 18.0(Chicago, IL, USA). Median diastema was seen in 16 cases (47.10%) in the mesiodens group. The mesiodens was most commonly impacted in the palatal (76.50%, n=26) and vertical (n= 19, 55.90%) position. There were significant differences between the incisor tooth development scores of the groups (p= 0.047 and p= 0.030, respectively). While the prevalence of H score of bilateral incisors in the control group (88.20% for both incisors) was higher than that of the mesiodens group (58.20% for both incisors), the G score was higher in the mesiodens group (20.60% and 23.50%) than in the control group (2.90% for both teeth). Mesiodens can delay root development of adjacent teeth.For this reason, extraction of these teeth may be considered in the early period to avoid affecting adjacent teeth and anatomical structures. It may also cause erroneous calculations in dental age determination. This situation should be taken into account in terms of forensic dentistry.Öğe Quality and content analyses of youtube videos related to medication-related osteonecrosis of jaws(Termedia Publishing House Ltd., 2021) Yaman, Deniz; Akay, Gulsun; Karadağ, Özge; Güngör, KahramanIntroduction: Medication-related osteonecrosis of jaws (MRONJ) is a condition that can cause pain and poor quality of life, requires professional approach for the maintenance of affected area, and is difficult to treat. Objectives: The aim of this study was to analyze the accuracy and quality of information provided about MRONJ of YouTube videos. Material and methods: A systematic search was conducted on YouTube using two keywords, including MRONJ and bisphosphonate-related osteonecrosis of the jaw. A total of 80 videos were evaluated. Video information and quality index (VIQI) were used to evaluate overall quality of videos. Comparison of categorical variables was performed with c2 and Fisher's exact tests. Correlation between characteristics of videos was analyzed using Kendall's tau-b correlation coefficient. Results: Most of the videos were found to be uploaded by doctors/dentists or maxillofacial surgeons (38.8%). The majority of videos were low-content videos. Most of high-content score videos were loaded by academic health institutions/professional organizations. Relationship between VIQI and usefulness (r = 0.801, p = 0.000) was found to be high. A positive correlation was observed between length of the video and interaction index (r = 0.226, p = 0.005). Conclusions: The majority of videos related to MRONJ contain videos with low-content/scores. Healthcare providers should be more engaged in providing accurate and reliable evidence-based information, and present their best practices information about MRONJ on YouTube. © 2021 Polish Dental Association
