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Öğe Cholelithiasis and gastrointestinal cancer: Is there a relationship that increases the risk of developing cancer?(2020) Özer, Bahri; Çatal, Oğuz; Özer, Songül Peltek; Keyif, Fatih; Şit, Mustafa; Kama, NuriAim: To investigate the co-existence of cholelithiasis in patients with gastrointestinal (GI) cancer both in preoperative and postoperative periods.Methods: We retrospectively analyzed the data of patients who underwent GI tract cancer surgery in the general surgery clinic of a university hospital between January 2013 and December 2019 for the presence of 'cholelithiasis' in the preoperative and postoperative periods. Age, gender, tumor type and localization and presence of the cholelithiasis in the patients were determined. In addition, the cases were divided into two as upper GI tract and lower GI tract according to tumor location and the relationship with cholelithiasis was evaluated.Results: A total of 680 GI cancer patients were included in the study. Localization of GI cancers were; colon in 211 cases (31%), rectum in 195 cases (28.7%), gastric in 187 cases (27.5%), periampullary region in 55 cases (8.1%), and small intestine in 32 cases (4.7%). In the preoperative period, 69 (10.1%) patients were associated with cholelithiasis. Thirty-one (5.1%) patients had accompanying cholelithiasis in the postoperative period. Coexistence of cholelithiasis according to cancer location was not statistically significant in the preoperative and postoperative periods.Conclusions: Our available data make it difficult to distinguish the roles of cholelithiasis on gastrointestinal cancers, because no statistically causal relationship was found between cholelithiasis and gastrointestinal cancers. However, the role of asymptomatic and symptomatic stones, which may or may not require cholecystectomy, in the development of GI tract cancers should not be ignored.Öğe Complete Blood Count parameters could predict malignancy in breast lesions(2020) Özer, Bahri; Çatal, Oğuz; Özer, Songül Peltek; Keyif, Fatih; Şit, Mustafa; Kama, NuriAim: Inflammatory response plays an important role in the development and progression of various cancers, including breast cancer.The aim of present study is determining Complete Blood Count parameters as possible predictors of malignancy in breast lesions.Material and Methods: Patients with BI-RADS-4 breast disease were studied between 2010 and 2017 retrospectively. Patients withlesions detected radiologically were included in the study. According to the histopathological results, the study cohort was dividedinto two groups, either benign or malignant. Final blood counts of the patients before pre-biopsy were evaluated in preoperativeperipheral blood measurements. When blood was taken, care was taken not to have other causes of leukocytosis in the patient.Complete Blood Count parameters were compared in these groups.Results: A total of 331 women with BI-RADS 4 lesions enrolled to the study. Mortality and morbidity were not observed after breastbiopsy in patients. Platelet (p=0.04), platelet to lymphocyte ratio (p=0.006) and red cell distribution width to platelet ratio (p=0.032)values of the patients with BI RADS 4A were found significantly different in the malignant group compared to benign BI RADS 4Agroup. In total BIRADS 4 lesions, the ratio of PLT and RPR was significant in malignant group (p=0.047, p=0.002) in Complete BloodCount parameters compared benign and malignant group.Conclusion: Studies have shown that cancer affects peripheral blood cells positively or negatively. In our study, among peripheralblood cells, platelets were found to be the most affected in cancer patients. The PLT, PLR and RPR values could be valuable inpredicting malignant BIRADS 4 breast lesions.Öğe Could red cell distribution width be a marker of thyroid cancer?(Coll Physicians & Surgeons Pakistan, 2017) Aktaş, Gülali; Şit, Mustafa; Karagöz, İbrahim; Erkuş, Edip; Özer, Bahri; Koçak, Mehmet Zahid; Yaman, Semih; Keyif, Fatih; Altınordu, Rabia; Erkol, Hayri; Şavlı, HalukObjective: To study red cell distribution width (RDW) values, a novel inflammatory marker in routine hemogram, of patients with benign or malignant thyroid nodules and to compare with healthy population. Study Design: Descriptive study. Place and Duration of Study: Abant Izzet Baysal University Hospital, Bolu, Turkey, from November 2015 and February 2017. Methodology: The hemogram values of patients undergone thyroid surgery for thyroid nodule between November 2015 and February 2017 were retrospectively analyzed, and compared to those in healthy subjects. Subjects with infectious or inflammatory diseases were excluded. Patients' characteristics and laboratory data were obtained from institutional computerized database. Preoperative hemogram values of thyroid nodule patients were recorded. One-way ANOVA and Kruskal-Wallis tests were performed to compare variables with significance at p<0.05. Results: Median RDW of malignant nodule group was 15.8 (12.9-19.5) and was significantly higher than both of those in benign nodule (15) and control groups (14), (p<0.001). Conclusion: Elevated RDW in patients with thyroid nodules in preoperative period should alert the physician for possible malignancy and this cost-effective marker also can help support other modalities (ultrasound scan, and fine needle aspiration biopsy) to distinguish malignant from benign nodules.Öğe Neutrophil to lymphocyte ratio is useful in differentiation of malign and benign thyroid nodules(Univ Puerto Rico Medical Sciences Campus, 2019) Şit, Mustafa; Aktaş, Gülali; Erkol, Mehmet Hayri; Yaman, Semih; Keyif, Fatih; Şavlı, HalukObjective: Significant amount of thyroid nodules are malignant. Inflammation plays crucial role in the pathogenesis of many disorders, including cancer. Neutrophil to lymphocyte ratio (NLR), has been suggested as an index of inflammatory response and association between increased NLR and cancer has also been reported. In this retrospective analysis, we aimed to study NLR levels in patients with malign and benign thyroid nodules and healthy control subjects. Methods: The patients who underwent surgery for nodular goiter in general surgery clinics of our university hospital between June 2012 and June 2015 and 68 healthy volunteers were included. Patients with thyroid nodules divided into malign or benign nodule groups according to the pathology report. Thyroid carcinomas other than micropapillary tumor were excluded. Preoperative hemogram parameters of these groups were compared. Results: Mean NLR of malign nodule group (2.1 +/- 0.9%) was significantly higher than both those in benign nodule (1.7 +/- 0.9%) and control groups (1.7 +/- 0.6%). Conclusion: We suggest that elevated NLR in patients with thyroid nodules in preoperative period may be an indicator of underlying malign nodular disease. Increased NLR in such patients should encourage physician to perform cancer screening in thyroid gland.
