Complete Blood Count parameters could predict malignancy in breast lesions

Aim: Inflammatory response plays an important role in the development and progression of various cancers, including breast cancer.The aim of present study is determining Complete Blood Count parameters as possible predictors of malignancy in breast lesions.Material and Methods: Patients with BI-RADS-4 breast disease were studied between 2010 and 2017 retrospectively. Patients withlesions detected radiologically were included in the study. According to the histopathological results, the study cohort was dividedinto two groups, either benign or malignant. Final blood counts of the patients before pre-biopsy were evaluated in preoperativeperipheral blood measurements. When blood was taken, care was taken not to have other causes of leukocytosis in the patient.Complete Blood Count parameters were compared in these groups.Results: A total of 331 women with BI-RADS 4 lesions enrolled to the study. Mortality and morbidity were not observed after breastbiopsy in patients. Platelet (p=0.04), platelet to lymphocyte ratio (p=0.006) and red cell distribution width to platelet ratio (p=0.032)values of the patients with BI RADS 4A were found significantly different in the malignant group compared to benign BI RADS 4Agroup. In total BIRADS 4 lesions, the ratio of PLT and RPR was significant in malignant group (p=0.047, p=0.002) in Complete BloodCount parameters compared benign and malignant group.Conclusion: Studies have shown that cancer affects peripheral blood cells positively or negatively. In our study, among peripheralblood cells, platelets were found to be the most affected in cancer patients. The PLT, PLR and RPR values could be valuable inpredicting malignant BIRADS 4 breast lesions.