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Öğe Abdominal actinomycosis: A case report mimicking colon tumor(Turkiye Klinikleri, 2006) Tamer, Ali; Gündüz, Yasemin; Karabay, Oğuz; İka, Hüseyin; Aksel, FerdaActinomyces spp., cause a chronic suppurative, granulomatous disease which is characterized clinically by extensive abscess formation, recurrent draining sinuses and fistulae and histologically by the presence of the so-called sulphur granules. Colonic actinomycosis is relatively rare, and its diagnosis is difficult. In this paper, we present a patient operated due to abdominal mass and diagnosed as transverse colon actinomycosis postoperatively, and discuss this case by reviewing the literature. Copyright © 2006 by Türkiye Klinikleri.Öğe Abdominal actinomycosis: a report of two cases(Acta Medical Belgica, 2006) Tamer, Ali; Gündüz, Yasemin; Karabay, Oğuz; Mert, AliActinomyces spp. cause a chronic suppurative, gramilomatous disease which is characterized clinically by extensive abscess formation, recurrent draining of sinuses and fistulae and histologically by the presence of the so-called "sulphur granules". Colonic actinomycosis is a relatively rare infection and its diagnosis is difficult. We report the case of a female patient who was operated on for ovarian cyst and the case of another female patient operated on for a mass in the transverse colon. In both cases the pathology of the excised tissues revealed actinomycosis. Actinomycosis must be considered in the differential diagnosis of patients who present with abdominal pain, fever, leucocytosis and intestinal wall thickness and/or abdominal mass.Öğe Akut tonsillofarenjitli hastalarda chlamydia pneumoniae ve mycoplasma pneumoniae antikorlarının araştırılması(2008) Yılmaz, Fahrettin; Karabay, Oğuz; Köybaşı, SerapAmaç: Bu çalışmada, akut tonsillofarenjit semptomlarıyla Kulak Burun Boğaz polikliniğine başvuran ve boğaz kültüründe A grubu beta hemolitik streptokok (AGBHS) saptanmayan olgularda Chlamydia pneumoniae ve Mycoplasma pneumoniae antikor sero-prevalansının araştırılması amaçlanmıştır. Gereç ve Yöntem: Çalışmaya boğaz kültüründe AGBHS saptanmayan ve yaşları 16 ile 59 arasında değişen (ort. 34.2) 12’si erkek, 20’si kadın toplam 32 olgu alındı. Olgulardan kan alınarak serum Mycoplasma pneumoniae ve Chlamydia pneumoniae antikorları mikro ELISA yöntemiyle ve ticari kitler kullanılarak çalışıldı. Bulgular: Olguların hiçbirinde M. pneumoniae Ig M pozitifliği saptanmazken 6 olguda (% 18.75) C. pneumoniae Ig M pozitifliği saptandı. Mycoplasma ve Chlamydia Ig G pozitifliği sırasıyla 6 (% 18.75) ve 19 (% 59.375) olguda saptandı. Sonuç: Bu sonuçlar Chlamydia pneumoniae ve Mycoplasma pneumoniae’nın akut tonsillofarenjit etiyolojisinde göz önünde bulundurulması gerektiğini göstermektedir.Öğe Andiscriminated aseptic meningitis case between rickettsia and leptospiral meningitis(TIP ARASTIRMALARI DERNEGI, 2008) Özdemir, Davut; Sencan, İrfan; Yıldırım, Mustafa; Güçlü, Ertuğrul; Yavuz, Tevik; Karabay, OğuzRickettsial meningitis and leptospiral meningitis should be included in the differential diagnosis of aseptic meningitis in patients exposed to endemic areas. In this report we describe a case of aseptic meningitis in which neither a rickettsial nor leptospiral etiology could be established.Öğe Ateş ölçümünde dört farklı vücut bölgesinin karşılaştırılması ve hasta tercihinin incelenmesi(2009) İlçe, Arzu; Karabay, OğuzAmaç: Bu çalışmanın amacı dört farklı vücut bölgesi (ağız, koltuk- altı, rektal ve kulak) kullanarak civalı termometre ile timpanik termometre ölçümlerini karşılaştırmak ve hasta tercihlerini belirlemektir. Materyal ve Metot: Tanımlayıcı tipte olan bu çalışma İzzet Baysal Bolu Devlet Hastanesinde, mart- nisan 2004 tarihleri arasında yatmakta olan ve çalışmaya katılmaya istekli 95 yetişkin hasta ile gerçekleştirildi. Timpanik ve civalı termometreler kullanarak dört farklı bölgeden ölçüm yapıldı ve hastaların her bir metodu değerlendirmeleri istendi. Bulgular: Ağız ile koltuk- altı yol arasında 0.19 0 C (ağız> koltuk- altı), ağız ile sağ kulak arasında 0.07 0 C (sağ kulak> ağız), ağız ile rektal yol arasında 0.45 0 C (rektal> ağız), koltuk- altı ile sağ kulak arasında 0.26OC (sağ kulak> koltuk- altı) fark olduğu saptandı. Hastaların vücut ısısı ölçümleri arasında en iyi yöntem olarak %73.40 (n: 69)’ının timpanik, iyi yöntem olarak %52.12 (n: 49)’sinin koltuk altı, orta yöntem olarak %72.34 (n: 68)’ ünün ağız ve tamamının kötü yöntem olarak rektal yoldan vücut ısısı ölçümünü bildirdi. Sonuç: Bu çalışma sonucunda vücuttan ateş ölçülen yer ve ölçümde kullanılan teçhizatlara göre belirgin ısı farkları saptanabilmektedir. Rektal termometreler ateşin belirlenmesinde daha etkin bulunmasına karşın özellikle yetişkinlerin tercih etmediği bir yöntem olduğundan hastanelerde yetişkinler için timpanik termometrelerin kullanımı daha uygun olduğu saptandı.Öğe Boğaz gargarası ile yapılan hızlı antijen testinin grup A beta-hemolitik streptokokları saptamadaki etkinliği(2008) Yılmaz, Fahrettin; Karabay, Oğuz; İnce, Koç Nevin; Ekerbiçer, Hasan; Koçoğlu, Mücahide EsraAmaç: Grup A beta-hemolitik streptokok (BHS) tanısında kullanılan hızlı antijen testlerinin (HAT) en önemli dezavantajı düşük duyarlılıklarıdır. Bu çalışmada, boğaz gargarası ile yapılan HAT'nin duyarlılık, özgüllük, pozitif ve negatif kestirim değerleri araştırıldı. Hastalar ve Yöntemler: Çalışmaya tonsillofarenjit öntanısı konan 106 hasta (53 kadın, 53 erkek, ortalama yaş 22±12; dağılım 16-65) alındı. Boğaz kültürü için steril pamuklu çubuk ile farenks arka duvarı ve tonsil yüzeyinden sürüntü örneği alındı. Daha sonra hastalara 10 saniye süreyle steril %0.9 NaCl ile gargara yaptırılarak örnek alındı. Bu örnekler HAT ile grup A BHS pozitifliği açısından değerlendirildi. Boğaz kültürleri standart yöntemlerle yapıldı. Bulgular: Boğaz kültürü 12 hastada (%11.3) pozitif, 94 hastada (%88.6) negatif idi. Boğaz gargarasıyla yapılan HAT beş hastada (%4.7) pozitif, 101 hastada (%95.2) negatif bulundu. Boğaz gargarasıyla yapılan hızlı antijen testinin duyarlılığı ve özgüllüğü sırasıyla %41.7 ve %100, pozitif kestirim değeri %100, negatif kestirim değeri %93.1 idi. Sonuç: Grup A BHS tanısında boğaz gargarasıyla yapılan HAT’nin özgüllüğü, pozitif ve negatif kestirim değerleri tatmin edici bulunmasına rağmen, duyarlılığı tatmin edici bulunmadı.Öğe Brucellar spondylitis (Pedro Pons' sign)(2007) Karabay, Oğuz; Gürel, Kamil; Sirmatel, Öcal; Sırmatel, FatmaA 39-year-old man presented to our hospital complaining of fever with chills, night sweats, and headaches of 3 months’ duration. The patient was suffering from severe lumbago, exacerbated by movement. Although he had physical therapy for his back pain, there was no improvement. On examination, his pulse was 80/min, blood pressure 110/70 mmHg, and temperature 37.8°C. Liver palpable 2 cm below the right costal margin was firm and non-tender. Other system examinations were unremarkable. Investigations revealed haemoglobin of 13.9 gm, ESR 60 mm/h, AST 45 U/L, and ALT 56 U/L (normal 0–40 U/L). Remaining blood biochemical parameters were within normal limits. Brucella serology in blood, done by the standard tube agglutination (STA) method, was positive with a titre of 1:320. Blood cultures were positive for Brucella spp by the BACTEC system. A plain lateral radiography revealed blunting of the anterosuperior corner of the L4 vertebrae (Figure 1). This finding arose the suspicion of erosion which was confirmed with a subsequent lumbar spine CT examination (Figure 2).Öğe Brusella endokarditi(2005) Özkökeli, Mehmet; Karabay, Oğuz; Arınç, Hüseyin; Tataroğlu, CenkBrusella türü bakterilerin neden olduğu Brusella enfeksiyonu, insanlara hastalıklı hayvanlardan direkt veya pastörize edilmemiş süt ve süt ürünlerinin kullanımı ile indirekt olarak bulaşır. Türkiye'de Sağlık Bakanlığının 2001 yılında yayınladığı rapora göre 15 000 yeni olgu bildirilmiş, ancak rapor edilmeyen ve subklinik vakalar göz önüne alınırsa bu rakam her yıl 50-100 000 olarak düşünülebilir. Bu yüzden Brusella Türkiyede önemli bir sağlık problemidir. Brusella endokarditi Brusellozun nadir fakat hayatı tehdit eden bir komplikasyonu olmasına rağmen, son zamanlarda tıbbi ve cerrahi tedavi birlikteliğiyle mortalite oranı belirgin olarak düşmüştür. Brusella enfeksiyonunun %1'inden azında kardiak tutulum görülür. Bu sunumda brusella endokarditinin temel özellikleri özetlenmeye çalışılmıştır.Öğe A case of melanonychia due to Candida albicans(Blackwell Publishing, 2006) Parlak, Ali Haydar; Göksüğür, Nadir; Karabay, OğuzCandida species rarely cause black pigmentation of infected nails and only a few cases have been reported in the literature. We describe a 53-year-old white man who had diffuse melanonychia of the fourth right fingernail due to C. albicans. A progressive dark pigmentation of his nail appeared over 6 months, following paronychial inflammation. The melanonychia was associated with brittleness. There was no onycholysis or hyperkeratosis. Direct examination with potassium hydroxide demonstrated round yeast cells in the specimen. The samples were cultured on Sabouraud glucose agar containing chloramphenicol at 27 degrees C and showed white growth after a few days. The patient was successfully treated with systemic itraconazole.Öğe Catheter associated Staphylococcus sciliuri sepsis in a patient with acute myeloid leukemia(2006) Koçoğlu, Esra; Karabay, OğuzThe coagulase-negative bacterial species Staphylococcus sciuri is widely distributed in the natural environment. Although principally found in animals, S.sciuri is occasionally isolated from human samples. In this paper, S.sciuri bacteremia which was associated with an indwelling catheter of a patient with acute myeloid leukemia (AML) and neutropenia was presented. An empirical intravenous antibiotic therapy (meropenem, vancomycin) was initiated with the preliminary diagnosis of febrile neutropenia and catheter infection. The catalase and oxidase positive, tube coagulase negative strain isolated from three of the concurrent blood cultures and intravenous catheter culture has been identified as S.sciuri. The isolate was found resistant to penicilin and oxacilline. This case has emphasized the importance of identification of coagulase-negative staphylococci isolated from the cultures of patients with haematological malignancy.Öğe Characteristics of the Turkish isolates of Francisella tularensis(National Instıtute Infectious Diseases, 2008) Gürcan, Şaban; Karabay, Oğuz; Karadenizli, Aynur; Karagöl, Çiğdem; Kantardjiev, Todor; Ivanov, Ivan N.In this study, cultures of patients with tularemia were evaluated, and antimicrobial susceptibilities of two Francisella tularensis strains were tested by disk diffusion and E-test methods. A high-resolution multiple-locus variable-number tandem repeat analysis (MLVA) comprising six variable-number tandem repeat loci was applied to elucidate the genetic relatedness among Turkish and Bulgarian isolates which were isolated in a recent outbreak. The patients were diagnosed in two outbreaks in two cities of Turkey in 2005 and 2006. A total of 16 samples from 12 patients were cultured, and PCR tests were carried out on 15 samples that were positive in five lymph node aspirates and two soft tissue aspirates. F. tularensis was isolated from the lymph nodes of two patients. Aminoglycosides, quinolones, chloramphenicole, tetracyclines, nitrofurantoin, and rifampicin inhibited growth of the isolates. The Turkish isolates appeared to share a common MLVA pattern with one of the four Bulgarian outbreak genotypes.Öğe Compliance and efficacy of hand rubbing during in-hospital practice(Karger, 2005) Karabay, Oğuz; Şencan, İrfan; Şahin, İdris; Alpteker, Hacer; Özcan, Arzu; Öksüz, ŞükrüObjective: To compare alcohol-based hand rubbing with hand washing using antimicrobial soap regarding antimicrobial efficacy and compliance with routine practice in hospital and intensive care units. Subjects and Methods: From February to June 2003, 35 nurses were randomly selected from a nursing staff of 141 and divided into two groups: hand rubbing and hand washing groups. Hand cultures were obtained before and after health care procedures. The nurses were observed on days 1, 7 and 14 of the study, in order to determine compliance and efficacy of the hand hygiene methods. Results: A total of 368 routine patient care activities were observed during the study period. Hand rubbing with alcohol-based solutions significantly reduced the bacterial contamination of the hands of the nurses more than hand washing with an antimicrobial soap (54 and 27%, respectively; p < 0.01). Compliance was also better in the hand rubbing group than in the hand washing group (72.5 and 15.4%, respectively; p < 0.001). Compliance with hand rubbing was markedly lower among the nurses who had experience of more than 3 years in hospital practice. Both hand rubbing and hand washing compliance were poorer among nurses working in intensive care units than among nurses working in the other hospital wards. Generally, after taking off gloves, nurses preferred hand washing to hand rubbing. Conclusion: These data indicate that alcohol-based hand rubbing reduces mean bacterial counts on the hands of nurses more effectively than hand washing with antimicrobial soaps, and compliance rates with hand rubbing were also higher than with hand washing. Nevertheless, the compliance with hand rubbing was markedly lower in more experienced nurses.Öğe Coxiella Burnetii seroprevalence in the rural part of Bolu, Turkey(2009) Karabay, Oğuz; Koçoğlu, Esra; Baysoy, Gökhan; Konyalıoğlu, SelamiAim: This study was performed to determine the seroprevalence of Coxiella burnetii in the rural part of Bolu, a city located in the western part of the Black Sea region of Turkey. Materials and Methods: The study population was chosen by cluster sampling to represent the rural population of the city. Serum samples were collected from the 9 rural districts of Bolu. Blood samples were taken to the laboratory while stored at 4 °C in ice-cooled boxes. The sera were then stored at −20 °C until testing. The presence of IgG antibodies against C. burnetii phase-II antigens in the sera was determined using IFA. Results: The study included 293 cases and C. burnetii phase-II IgG was positive in 61 of the subjects (20.8%). The seroprevalence of C. burnetii was 23.8% (59/248) among the participants above 18 years of age and 4.4% (2/45) among those younger than 18 years of age (P < 0.01). There was a significant relationship between C. burnetii seropositivity and direct contact with the birth products of farm animals (P < 0.001); however, there was not a significant difference between genders. Conclusions: Although the seroprevalence rate was high, Q fever was underreported and unrecognized in rural Bolu. We conclude that Q fever must be considered in patients with a suitable clinical course in this region.Öğe Does prebiopsy, nonsterile ultrasonography gel affect biopsy-site asepsis?(Springer, 2008) Gürel, Kamil; Karabay, Oğuz; Gürel, Safiye; Hildebolt, CharlesPurpose The purpose of this study was to determine the extent to which the use of nonsterile gel, prior to antiseptic procedures in ultrasonography (US)-guided percutaneous biopsies, results in contamination of the biopsy site. Materials and Methods Patients referred for US-guided percutaneous biopsies were included in this study. Transmission material used for US evaluation before biopsy-site antiseptic procedures were performed was either nonsterile gel or sterile saline. Patients were randomly assigned to two groups: nonsterile gel (n = 30) and sterile saline (n = 30). Before the transmission material was used and after antiseptic procedures were performed, microbial swabs of a 10-cm(2)-diameter area were obtained at the biopsy site. Swabs were also obtained from the gel, saline, and povidine-iodine. Inoculated specimen plates were incubated at 37 degrees C under aerobic conditions, and the numbers of colony-forming units recorded. Nominal logistic regression analysis was used to calculate the odds of postantisepsis bacterial growth (after antiseptic procedures were performed) based on group, gender, coincidental disease (diabetes, chronic renal failure, and malignancy), biopsy-site location (head and neck or breast and abdomen), and local factors (skin fold, skin tag, and hair). Results The following odds ratios (adjusted for the other variables) and their 95% confidence intervals were calculated: (1) group (2.9 [0.8-11.1]; p = 0.10); (2) gender (1.2 [0.3-5.2]; p = 0.78); (3) coincidental disease (7.6 [0.9-166.7]; p = 0.09); (4) biopsy site location (6.2 [1.4-31.3]; p = 0.02); and (5) local factors (7.0 [1.6-36.0]; p = 0.01). No bacterial growth occurred with swabs obtained from gel, povidine-iodine, or saline. Conclusion We conclude that nonsterile gel used prior to percutaneous biopsy does not affect biopsy-site asepsis.Öğe Effect of inhaled budesonide on oropharyngeal, Gram-negative bacilli colonization in asthma patients(Asian Pacific Society of Respirology, 2007) Talay, Fahrettin; Karabay, Oğuz; Yılmaz, Fahrettin; Koçoğlu, EsraBackground and Objective: The effect of inhaled budesonide on oropharyngeal Gram-negative bacilli colonization (OGNBC) in asthmatic patients was investigated. Methods: Oropharyngeal cultures were obtained from asthmatic patients attending the hospital respiratory outpatient clinic, at baseline and 1 month after treatment with 800 mu g/day of inhaled budesonide. Cultures were evaluated for OGNBC and compared with those of healthy controls. Results: A total of 148 cultures (74 from asthma patients, 74 from healthy controls) were evaluated. Six cultures (8.1%) from healthy controls, eight cultures (10.8%) from asthma patients obtained before treatment and 20 cultures (27.0%) obtained after treatment were positive for OGNBC (P < 0.05). Gender, age, presence of atopy and the degree of illness were not found to be related to the presence of OGNBC in and healthy control cultures. In the cultures obtained from the patients after treatment, OGNBC was higher in patients > 50 years and in those with FEV1 < 70% (P < 0.05). Nine (18.8%) of 48 patients < 50 years compare with 11 (42.3%) of the 26 patients > 50 revealed OGNBC (P < 0.05). OGNBC were observed in 18.9% of the patients with FEV1 = 70% and in 47.6% of those with FEV1 < 70% (P < 0.05). Conclusions: The increased rate of OGNBC in asthma patients treated with inhaled budesonide was found to be related to increased age and lower level of FEV1. Further studies with larger numbers of patients are required for the interpretation of this colonization in the course of lower respiratory infections in these patients.Öğe The effect of triamcinolone acetonide aqueous nasal spray on the nasal carriage of Staphylococcus aureus(Ocean Side Publications Inc, 2006) Yılmaz, Fahrettin; Karabay, Oğuz; Talay, Fahrettin; Köybaşı, Serap; Koçoğlu, EsraBackground: In this study we aimed to investigate the effect of triamcinolone acetonide aqueous (TAA) intranasal spray that was used for 2 months to treat allergic rhinitis (AR) on the nasal carriage of Staphylococcus aureus (NCSA). Methods: A total of 125 adult AR patients (study group) and 133 healthy individuals (control group) were enrolled for the study. The 14 subjects were diagnosed with AR after a detailed history, physical examination, and prick testing. The AR subjects were administered TAA in a daily dosage of a 220-mu g intranasal route. Nasal cultures were obtained on the 1st (baseline), 55th, and 60th days, and the subjects in the last two cultures of whom S. aureus was detected were accepted as NCSA. Results: After all exclusion criteria were used, 110 AR and 114 control group subjects were enrolled in the study. Based on the culture results that were obtained on the 55th and 60th days, 10 (%9.1) patients from the study group and 18 (%15.7) individuals from the control group were defined to be NCSA (p>0.05). Conclusion: We conclude that the use of TAA treatment for AR does not increase the prevalence of NCSA. However, additional studies with a larger series are required to explain the effects of steroids on nasal colonization of S. aureus.Öğe Effectiveness of lamivudine and interferon-? combination therapy versus interferon-? monotherapy for the treatment of HBeAg-negative chronic hepatitis B patients: A randomized clinical trial(2005) Karabay, Oğuz; Tamer, Ali; Tahtaci, Mustafa; Vardi, Şeref; Çelebi, HarikaResults comparing the effectiveness of lamivudine used as monotherapy or in combination with interferon-alpha (IFN-?) in the treatment of chronic hepatitis B are not conclusive. This study compared the effects of IFN-? alone or in combination with lamivudine for the treatment of hepatitis B e antigen (HBeAg)-negative patients with chronic hepatitis B. Participation of patients in the IFN-? monotherapy and combination groups was randomized to a 1:1 ratio. Twenty seven HBeAg-negative patients with chronic hepatitis B received IFN-? (13 patients) at 9 million units 3 times weekly for 24 weeks or IFN-? at 9 million units 3 times weekly for 24 weeks plus lamivudine 100 mg/day (14 patients) daily for 1 year. Hepatitis B virus (HBV) DNA was measured quantitatively by real-time polymerase chain reaction at 0, 6, 12 and 18 months after the start of treatment. Sustained virologic response was defined as non-detectable serum HBV DNA 72 weeks after starting treatment. Sustained biochemical response was defined as normalization of alanine aminotransferase (ALT) values 72 weeks after starting treatment. The baseline characteristics of the 2 treatment groups were similar with respect to age, gender, ALT, HBV DNA levels and histologic diagnosis. Sustained biochemical responses were found at week 72 in 7 patients in each group (54% with IFN-? monotherapy and 50% with combination therapy) [p>0.05]. Sustained virologic responses were found at week 72 in 5 patients (38%) in the monotherapy and 7 patients (50%) in the combination therapy group (p>0.05). Combination therapy was not superior to IFN-? alone for the treatment of chronic hepatitis B. Combination treatment was associated with some disadvantages, such as additional cost. Lamivudine, on the other hand, may be more suitable for patients with cirrhosis, non-responders to IFN-? or in cases with contraindication for IFN-?.Öğe The efficiency of two-dose hepatitis B vaccination in health care workers for immunoprophylaxis(Turkiye Klinikleri, 2006) Karabay, Oğuz; Tamer, Ali; Koç İnce, Nevin; Büyükahraz, Nisa; Vardı, ŞerefObjective: Previous studies showed that 2 dose vaccinations 4 months apart were as effective as 3 dose vaccination schedules. In this study, we aimed to investigate the reliability and efficiency of 2 doses of Hepatitis B vaccine in health care workers. Material and Methods: Two dose and 3 dose vaccination groups who were negative for HBsAg, anti-HBcIgG and anti-HBs were selected among health care workers working in the İzzet Baysal Medical Faculty and were randomized in a 1:1 ratio. The 2 dose group included 36 subjects and 33 subjects were present in the 3 dose group. The 2 dose group was vaccinated with 20 ?g of vaccine at 0 and 4 months and the same dose was administered to the 3 dose group at 0, 1, and 6 months. Geometric Mean Titers (GMT) were calculated by measuring the level of anti-HBs quantitatively 2 months after the last shot in both groups. Results: GMT values of the 2 and 3 dose groups were determined as 314.5 and 599.2 IU/mL, respectively (p< 0.01). While the number of subjects with antibody titers under the protective level (anti-HBs<10 IU/mL) was 11 in the 2 dose group, only 1 patient in the 3 dose group had low antibody levels at the end of the vaccination schedule (p< 0.05). No significant difference was observed in terms of adverse effects between the 2 groups (p> 0.05). Conclusion: Although encouraging results were obtained in recent studies, the 2 dose vaccination schedule at 0 and 4 months used in our study for hepatitis B prophylaxis in health care workers was not as effective as the standard schedule. Thus, larger studies are required. Copyright © 2006 by Türkiye Klinikleri.Öğe Eyelash and eyebrow trichomegaly induced by interferon-alfa 2a [5](2007) Göksungur, N.; Karabay, OğuzAdverse effects due to interferon (IFN)-alfa have been well documented, usually as influenza-like symptoms, depression, autoimmune diseases, acute renal failure and neuropathy.1 The most commonly encountered skin and hair disorder related to IFN-alfa therapy is alopecia, but changes in hair pigment (discoloration, greying, repigmentation) and appearance (curling or straightening) have also been reported.2 Hypertrichosis has also been reported as a rare side-effect of therapy, especially of the eyelashes.3–5 We report a patient treated with IFN-alfa-2a who developed trichomegaly of the eyelashes and eyebrows. To our knowledge, this is the first case of trichomegaly related to IFN-alfa-2a therapy.Öğe Frequency of nasal helicobacter pylori carriage among cooks(Pakistan Medical Assoc, 2013) Karabay, Oğuz; Güçlü, Ertuğrul; Koçoğlu, Esra; Özdemir, Davut; Şencan, İrfanObjective: To investigate the frequency of nasal helicobacter pylori carriage among cooks living in Bolu, Ardahan and Sakarya province of Turkey. Methods: A total of 54 cooks (10 from Bolu, 29 from Ardahan and 15 from Sakarya) were enrolled. Nasal helicobacter was tested using polymerase chain reaction. Results: Helicobacter pylori was detected in only one cook. Conclusion: Nasal Helicobacter pylori colonisation ratio in cooks in Turkey was found to be very low. Presumably hand hygiene compliance lowered the frequency.
