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Öğe Comparison of all hand digit length ratios in left - and righthanded individuals(2012) Kosif, Rengin; Diramali, MuratAmaç: Beyin hemisferlerinden bir tanesi daha baskındır ve hangi hemisferin daha baskın olduğunun bilinmesi bireysel aktivitelerin yönlendirilmesinde önemlidir. Bu çalışma sağlak ve solak kız ve erkek öğrencilerde parmak uzunluğu ve parmak uzunluklarının birbirlerine oranları arasındaki olası farklılıkları saptamak için yapıldı. Yöntem ve gereç: 1-5. parmak uzunlukları ölçüldü (D). Ardından tüm parmakların diğer parmaklara olan oranı hesaplandı (1D:2D, 1D:3D, 1D:4D, 1D:5D, 2D:3D, 2D:4D, 2D:5D, 3D:4D, 3D:5D ve 4D:5D). Bulgular: Erkeklerde parmak uzunlukları ve birbirlerine olan oranları arasında anlamlı fark bulunamadı. Solak kızlarda 5. parmak uzunluğu ve 2D:5D, 3D:5D, 4D: 5D oranları arasında istatistiksel olarak anlamlı fark vardı. Solak kızlarda bu oranlar sol ellerinde sağ ellerine göre daha küçüktü ve 5. parmağın solak kızlarda daha uzun olduğunu gösteriyordu. Sonuç: Bu sonuçlar solak kızların topu yakalamayı gerektiren sporlarda daha başarılı olabileceklerini göstermektedir ve sporcu seçiminde solak kızlarda bu kriterin göz önünde bulundurulması faydalı olacaktır.Öğe Comparison of all hand digit length ratios in left- and right-handed individuals(Tubitak Scientific & Technological Research Council Turkey, 2012) Kosif, Rengin; Diramali, MuratAim: To compare and detect possible differences between the digit length and digit length ratios in left- and right-handed female and male students. One of the cerebral hemispheres is dominant over the other. Knowing a person's dominant hemisphere cart be a useful guide in some personal activities. Materials and methods: Digit lengths (D) of the students were measured, followed by calculating the ratio of each digit to the others (1D:2D, 1DÖğe COVID-19 Pandemisi: Uzaktan Eğitimin Sağlık Alanında Eğitim Gören Öğrenciler Üzerindeki Etkileri(2023) Saylan, Aslihan; Deniz, Omur Gulsum; Diramali, MuratAmac?: Tu?m du?nyayı etkisi altına alan koronaviru?s salgını sebebiyle aniden gec?ilen uzaktan eg?itim sisteminin sağlık alanında eğitim alan öğrenciler tarafından değerlendirilmesi amac?lanmıs?tır. Gereç ve Yöntemler: Uygulamalı eg?itimin o?nemli bir yer tuttug?u Bolu Abant İzzet Baysal U?niversitesi Diş Hekimliği Fakültesi, Sağlık Bilimleri Fakültesi, Tıp Fakültesi ve Sag?lık Meslek Yu?ksekokulu’nda o?g?renim go?ren 505 o?g?renci tarafından cevaplandırılan 43 soruluk anket c?alıs?ması fakto?r analizi ile incelendi. Sosyo-demografik veriler sayı ve yüzde olarak ifade edildi. Faktörlerin sosyodemografik değişkenlere göre değerlendirilmesinde cinsiyet için Mann-Whitney U; eğitim, okul ve uzaktan eğitime erişim şekli için ise Kruskal-Wallis testleri kullanıldı. Bulgular: Anket çalışmasına 357 (%70,69) kadın, 148 (%29,31) erkek öğrenci katıldı. Bu kapsamda; öğrencilerin cinsiyetleri ile mesleki kaygı (p=0,030) ve online ders takibi (p=0,001) bakımından anlamlı farklılıklar bulundu. Ek olarak eğitim düzeyine göre sistemik altyapı (p=0,007) ve çevrimiçi ders takibi (p=0,029) açısından anlamlı farklılıklar görülmüştür. Öğrencilerin okudukları okul ile mesleki kaygı arasında ise anlamlılık gözlenmedi (p=0,101). Sonuç: O?g?rencilerin uzaktan eg?itime bakışları olumlu olmakla birlikte, memnuniyetlerini etkileyen fakto?rler deg?is?mektedir. Her ne kadar pandemi koşullarında uzaktan eğitim iyi bir bir altenatif olarak düşünülse de uygulamalı dersler ac?ısından o?g?renciler yu?z yu?ze eg?itimi tercih etmektedirler.Öğe Effect of foot anthropometric measurements on postural stability(2020) Meyvaci, Seda Sertel; Meyvaci, Turgut; Kosif, Rengin; Diramali, Murat; Ankarali, HandanAim: To examine the effect of foot anthropometric measurements and body sizes of young maleadults with normal posture on balance.Methods: In this study, the effect of body size and foot anthropometric measurements of 112 youngmale adults with normal posture on balance was investigated. The foot and body parameters of thecases were measured. The static and the dynamic balance tests were evaluated according to thedominant foot in each case. The parameters that affected balance were determined and the variableswere taken to the model. In addition, the significance levels that defined the effects of the propertiesexamined in relation with the balance were also calculated.Results: When the findings were evaluated, it was determined that the effect of the foot parametersother than the foot length, and the effect of 15 body parameters other than the biiliac diameter,trochanteric height, and right upper extremity length on balance performance was significant. Thebalance test performance was predicted with success ranging from 7.8% to 43% with the parametersincluded in the model.Conclusion: In this study, the fact that the relation between the foot anthropometric and bodydimensions and functional balance performances of young male adults was found to be significantshows that this relation must be considered in the creation of a normative database on balance, and inclinical studies that will be conducted on the subject.Öğe Evidence for heterogeneity in response to treatment in mammary tumors of dogs as happens in humans(Springer Science and Business Media B.V., 2023) Turna, Ozge; Uvez, Ayca; Baykal, Aslihan; Sedef Develi, Elif; Diramali, Murat; Sonmez, Kivilcim; Karakas, DidemTumors are formed by various clones developed over a long time. This gives rise to a heterogeneous nature. This heterogeneity is the hardest challenge in the treatment of cancers because it is the main reason for drug resistance. This is a well-known fact in human cancer. Therefore, we have reasoned that if the tumor heterogeneity in canine mammary gland tumors (CMGTs) could be shown by an ex vivo assay, which will be used first time in veterinary oncology practice, this could be used further in clinics. To achieve this, twenty-six patients were included in the study. Tumor tissues were obtained from animals during routine surgery. Tumor cells were isolated and seeded ex vivo. The cells were exposed to anticancer drugs that are clinically used. Seven days after the treatment, chemosensitivity has luminometrically been assayed by ATP-tumor chemosensitivity assay (ATP-TCA). It has clearly been shown that all the tumor tissues have responded to treatment differently, implying that heterogeneity exists in mammary tumors. There has also been found that there was a weak to moderate statistically significant correlation between tumor size and drug index. However, there has been no correlation between drug index and metastasis to lymph nodes. Hyperplasic areas had relatively higher PCNA values. The results of our study demonstrate the heterogeneity in responses to in vitro drugs. Clinical trials based on test results and follow-up studies with large numbers of animals are needed to prove that such chemotherapeutic activity assessment tests can be clinically useful in predicting drug responses in CMGTs. © 2022, The Author(s), under exclusive licence to Springer Nature B.V.Öğe Genetic Investigation of the Trail Mechanism in Diabetic and Non-diabetic Obese Patients(Springer/Plenum Publishers, 2024) Sezgin, Saadet Busra Aksoyer; Durak, Sermin; Celik, Faruk; Gheybi, Arezoo; Diramali, Murat; Cakmak, Ramazan; Gurol, Ali OsmanObesity is an important healthcare issue caused by abnormally increased adipose tissue because of energy-intake overcoming energy expenditure. Disturbances in the physiological function of adipose tissue mediate the development of diabetes. It is a metabolic disease that results from decreased insulin-levels and/or changes in the insulin action mechanism. Tumor Necrosis Factor-Associated Apoptosis-Inducing Ligand(TRAIL), which is a member of the Tumor Necrosis Factor(TNF)-family with an important role in adipose tissue biology, is included in many studies with its ability to induce apoptosis in cancer cells, but the number of human-studies conducted on the gene related to its protective-role against diabetes and obesity at this level is insufficient. Our study was carried out as a case and control and included three groups (80 diabetic obese, 80 non-diabetic obese, and 80 healthy individuals as the control group). The Real-Time-PZR(RT-qPZR), and DNA Sanger-Sequencing Methods were used for gene expression and gene squences. As a result of the analyses, TRAIL gene expression level was found to be higher in the controls than in the diabetic-obese and non-diabetic-obese group. This change in TRAIL gene expression suggests that TRAIL maybe a protective factor against diabetes. The presence of rs781673405, rs143353036, rs1244378045, rs767450259, rs759369504, rs750556128, and rs369143448 mutations, which was determined with the Sequencing-Method, was shown for the first time in the present study. In addition, it is the first study in which human TRAIL gene-expression and sequencing were performed together. We believe that these data will make an important contribution to the literature.Öğe Investigation of variants of critically important antioxidant enzyme genes in patients with polycystic ovary syndrome(2019) Arslan, Ali Osman; Çelik, Faruk Ömer; Küçükhüseyin, Özlem; Duran, Bülent; Diramali, Murat; Zeybek, Şakir Ümit; Düzenli, Selma GepdiremenAim: To investigate the possible effects of polymorphisms in genes encoding some importantantioxidant enzymes such as super oxide dismutase 2 (SOD2), glutathione peroxidase 1 (GPX1),endothelial NOS (eNOS) and catalase (CAT) in patients with polycystic ovary syndrome (PCOS).Methods: Peripheral blood of 100 patients with PCOS and 100 healthy control group were collected,Polymorphisms in related genes was investigated by using polymerase chain reaction-restrictionfragment length polymorphism. In addition, the related biochemical values of the patients were alsoinvestigated.Result: In our study there is no significant results for SOD2 gene but the results obtained betweenGPX1, eNOS and CAT genes were significant. Fasting blood sugar (FBS), insulin, triglyceride, waistcircumference and dehydroepiandrosterone sulphate (DHEAS) were found to be significant with thedisease, whereas follicle-stimulating hormone (FSH) was found to be effective in preventing thedisease.Conclusions: These findings suggest that polymorphisms in genes encoding GPX1, eNOS and CATenzymes may be associated with PCOS. Additionally, it is thought that the genes of FBS, triglyceride,insulin, DHEAS and waist circumference are important in the pathogenesis of the disease in thepresence of homozygous mutation.
