Investigation of variants of critically important antioxidant enzyme genes in patients with polycystic ovary syndrome
Küçük Resim Yok
Tarih
2019
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Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Aim: To investigate the possible effects of polymorphisms in genes encoding some importantantioxidant enzymes such as super oxide dismutase 2 (SOD2), glutathione peroxidase 1 (GPX1),endothelial NOS (eNOS) and catalase (CAT) in patients with polycystic ovary syndrome (PCOS).Methods: Peripheral blood of 100 patients with PCOS and 100 healthy control group were collected,Polymorphisms in related genes was investigated by using polymerase chain reaction-restrictionfragment length polymorphism. In addition, the related biochemical values of the patients were alsoinvestigated.Result: In our study there is no significant results for SOD2 gene but the results obtained betweenGPX1, eNOS and CAT genes were significant. Fasting blood sugar (FBS), insulin, triglyceride, waistcircumference and dehydroepiandrosterone sulphate (DHEAS) were found to be significant with thedisease, whereas follicle-stimulating hormone (FSH) was found to be effective in preventing thedisease.Conclusions: These findings suggest that polymorphisms in genes encoding GPX1, eNOS and CATenzymes may be associated with PCOS. Additionally, it is thought that the genes of FBS, triglyceride,insulin, DHEAS and waist circumference are important in the pathogenesis of the disease in thepresence of homozygous mutation.
Açıklama
Anahtar Kelimeler
Kaynak
Experimental Biomedical Research
WoS Q Değeri
Scopus Q Değeri
Cilt
2
Sayı
1
