Investigation of variants of critically important antioxidant enzyme genes in patients with polycystic ovary syndrome

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dc.contributor.authorArslan, Ali Osman
dc.contributor.authorÇelik, Faruk Ömer
dc.contributor.authorKüçükhüseyin, Özlem
dc.contributor.authorDuran, Bülent
dc.contributor.authorDiramali, Murat
dc.contributor.authorZeybek, Şakir Ümit
dc.contributor.authorDüzenli, Selma Gepdiremen
dc.date.accessioned2024-09-25T20:18:23Z
dc.date.available2024-09-25T20:18:23Z
dc.date.issued2019
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractAim: To investigate the possible effects of polymorphisms in genes encoding some importantantioxidant enzymes such as super oxide dismutase 2 (SOD2), glutathione peroxidase 1 (GPX1),endothelial NOS (eNOS) and catalase (CAT) in patients with polycystic ovary syndrome (PCOS).Methods: Peripheral blood of 100 patients with PCOS and 100 healthy control group were collected,Polymorphisms in related genes was investigated by using polymerase chain reaction-restrictionfragment length polymorphism. In addition, the related biochemical values of the patients were alsoinvestigated.Result: In our study there is no significant results for SOD2 gene but the results obtained betweenGPX1, eNOS and CAT genes were significant. Fasting blood sugar (FBS), insulin, triglyceride, waistcircumference and dehydroepiandrosterone sulphate (DHEAS) were found to be significant with thedisease, whereas follicle-stimulating hormone (FSH) was found to be effective in preventing thedisease.Conclusions: These findings suggest that polymorphisms in genes encoding GPX1, eNOS and CATenzymes may be associated with PCOS. Additionally, it is thought that the genes of FBS, triglyceride,insulin, DHEAS and waist circumference are important in the pathogenesis of the disease in thepresence of homozygous mutation.en_US
dc.identifier.doi10.30714/j-ebr.2019147578
dc.identifier.endpage19en_US
dc.identifier.issn2618-6454
dc.identifier.issue1en_US
dc.identifier.startpage8en_US
dc.identifier.trdizinid383564en_US
dc.identifier.urihttps://doi.org/10.30714/j-ebr.2019147578
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/383564
dc.identifier.urihttps://hdl.handle.net/20.500.12491/15646
dc.identifier.volume2en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofExperimental Biomedical Researchen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzYK_20240925en_US
dc.titleInvestigation of variants of critically important antioxidant enzyme genes in patients with polycystic ovary syndromeen_US
dc.typeArticleen_US

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