THE EFFECTS OF INTRAPERITONEAL MELATONIN INJECTION AND PINEALECTOMY IN EXPERIMENTAL ACUTE PANCREATITIS

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dc.contributor.authorDinler, Kahraman
dc.contributor.authorHasdemir, Ahmet Oguz
dc.contributor.authorCol, Cavit
dc.contributor.authorGunduz, Blent
dc.contributor.authorBugdayci, Gler
dc.contributor.authorKukner, Aysel
dc.date.accessioned2024-09-25T19:56:09Z
dc.date.available2024-09-25T19:56:09Z
dc.date.issued2009
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractObjectives: In this study the aim was to evaluate the effects of on biochemical markers and histopathological findings of pancreas tissue of decreeasing and increasing serum melatonin levels in rats with had experimental acute pancreatitis. Materials and methods: This study was conducted three groups of Winstar Albino rats (ten animals in every group) that have experimental acute pancreatitis. First group was evaluated as control group. Surgical pinealectomy was applied in the second group and the source of endogen melatonin was (low melatonin levels group). Third group of rats injected with 0.1 ml daily intraperitoneal injection of 20 mg/ml melatonin solution for one week was high melatonin levels group. The effects of melatonin levels on acute pancreatitis were evaluated by comparing these group according to histopathologial results of polimorphonuclear leukocytes. infiltration, oedema, haemorrhagie, apoptosis, aciner cellular degeneration in pancreatic tissue and the levels of malonyledialdeyde (MDA), glutathione reductase (GSH), superoxyde dismutase (SOD), aspartate transaminase (AST), alanine transpherase (ALT), amylase, lactate dehydrogenase (LDH) and bilirubine. Results: We investigated that high melatonin levels has an decreasing effect on of polimorphonuclear leukocyte infiltration, oedema, haemorrhage, aciner cellular degeneration, apoptosis in pancreatic tissue, AST, LDH, bilirubine and MDA levels. Conclusion: As a conclusion exogenous melatonin may have a preventive effect on inflammatory process by reducing oxidative damage in pancreatic tissue.en_US
dc.identifier.endpage92en_US
dc.identifier.issn1305-6433
dc.identifier.issn1305-6441
dc.identifier.issue3en_US
dc.identifier.startpage84en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/13149
dc.identifier.volume72en_US
dc.identifier.wosWOS:000409820800002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isotren_US
dc.publisherIstanbul Univ, Faculty Medicine, Publishing Officeen_US
dc.relation.ispartofJournal of Istanbul Faculty of Medicine-Istanbul Tip Fakultesi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzYK_20240925en_US
dc.subjectAcute pancreatitisen_US
dc.subjectmelatoninen_US
dc.subjectpinealectomyen_US
dc.titleTHE EFFECTS OF INTRAPERITONEAL MELATONIN INJECTION AND PINEALECTOMY IN EXPERIMENTAL ACUTE PANCREATITISen_US
dc.typeArticleen_US

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