Umblikal kord büyüme faktörlerinin fetal büyüme üzerine etkisi
Küçük Resim Yok
Tarih
2005
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Bolu Abant İzzet Baysal Üniversitesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Bu çalışmada miadında doğan bebeklerin kord venöz kanı örneğinde leptin, Insulin Benzeri Büyüme Faktörü-I (IGF-I), însülin Benzeri Büyüme Faktörü-II (IGF-II), Insulin Benzeri Büyüme Faktörü Bağlayıcı Protein-3 (IGFBP-3) ve kord arteryel karımda insulin, kortizol ve büyüme hormonlarına bakılarak bunların fetal büyüme üzerine etkilerinin araştırılması amaçlandı. Materyal-Metod: Çalışmaya 82 sağlıklı anneden doğan term yenidoğanlar (37 kız, 45 erkek) ve anneleri alındı. Vakaların antropometrik ölçümleri, plasental ağırlığı, annelerin gebelik boyunca aldığı kilo artışı tespit edildi. Umblikal kord kanında IGF-I, IGF-II, IGFBP-3, leptin, kortizol, büyüme hormonu (BH), insülin düzeyleri analiz edildi. Bulgular: Kord kanı IGF-I seviyeleri ile bebek doğum ağırlığı ( p<0.01; r= 0,27); boy (p<0.01; r=0.26) ve plasental ağırlık (p<0.01; r= 032) arasında anlamlı korelasyon saptandı. Kord kam leptin seviyesi ile bebek doğum ağırlığı (p<0.05; r=0.23) ve vücut kitle indeksi (p<0.01; r=0.33) arasında pozitif korelasyon saptandı. Plasental ağırlık ile doğum ağırlığı (p<0.001; r=0.8), uzunluk (p<0.001; r-0.62), baş çevresi ((p<0.001; r=0.47) ve vücut kitle indeksi (p<0.001; r=0.71) arasmda anlamlı korelasyon saptandı. Venöz kord kam serum leptin seviyesi ile arteryel kord serum insülin seviyesi arasmda korelasyon saptandı (p <0.01; r=0.37). Multipl Lojistik Regresyon (MLR) analizi sonucu ağırlık üzerine etkin parametre olarak sırasıyla plasenta ağırlığı (MR=0.82) ve leptin (MR=0.63), olarak belirlendi. IGF-I, insülin ve BH'nun zayıf etkisi olduğu izlendi. MLR analizine göre uzunluk üzerine en etkin parametreler sırasıyla; plasental ağırlık (r=0.47; MR=0.68) ve leptin (r=0.16; MR=0.41) olarak belirlendi. Sonuç: Bu çalışmadaki veriler, kord kanındaki leptin, IGF-I seviyeleri ve plasentanın fetal büyümenin düzenleyicisi olduğunu desteklemektedir. Fetal leptin seviyeleri, fetal uzunluğun aksine fetal kilo alımının düzenlenmesini önemli ölçüde etkiliyor gibi görünmektedir. Fetal büyüme üzerine insülin ve leptin pozitif bir etkileşme göstermektedir. Plasenta bir endokrin organ olarak görülmekte ve salgıladığı faktörlerle fetal büyümeye önemli katkıda bulunmaktadır. 40
Aim: The aim of this study was to determine the levels of leptin, insulin-like growth factor-I (IGF-I), insulin-like growth factor-II (IGF-II) and insulin-like growth factor-binding protein 3 (IGF-BP3) in venous cord blood, and the levels of insulin, Cortisol and growth hormone (GH) in arterial cord blood of term neonates, and to search the effects of these factors on fetal growth. Material and Method: In this study, 82 term newborns (37 female, 45 male infants) born to healthy mothers, and their mothers were included. Anthropometric measurements of the cases, placental weight and weight gain of the mothers during pregnancy were all recorded. The levels of IGF-I, IGF-II, IGF-BP3, leptin, Cortisol, GH and insulin in cord blood were analyzed. Results: A significant correlation was found between IGF-I levels and birthweight (p<0.01; r=0.27), birth length (p<0.01; r=0.26) and placental weight (p0.01; r=0.32). In addition, a positive correlation was shown between cord blood leptin levels and birth weight (p<0.05; r=0.23), and body mass index (p<0.01; r=0.33). Apart from these, a significant correlation was found between placental weight and birth weight (p<0.001; r=0.80), birth length (p<0.001; r=0.62), head circumference (p<0.001; r=0.47) and body mass index (p<0.001; r=0.71). Additionally, a correlation was shown between venous cord blood leptin levels and arterial cord serum insulin levels (p<0.01; r=0.37). Through "Multiple Logistic Regression" analysis (MLR), parameters affecting the weight were shown as placental weight (MR=0.82), and leptin (MR=0.63) in decreasing order regarding MR values. It was noted that IGF-I, insulin and GH only slightly affected the birth weight. Using MLR analysis, it was found out that parameters affecting birth length were placental weight (r=0.47; MR=0.68), and leptin (r=0.16; MR=0.41), in decreasing order regarding MR values. Conclusion: The findings of this study supported the hypothesis that leptin and IGF-I levels in cord blood, and placenta regulate fetal growth. Fetal leptin levels seem to influence the regulation of fetal weight gain in contrast to fetal length. Insulin and leptin exhibit a positive interaction regarding fetal growth. Placenta is regarded as an endocrin organ, and it contributes significantly to the fetal growth through the factors it secrets. 41
Aim: The aim of this study was to determine the levels of leptin, insulin-like growth factor-I (IGF-I), insulin-like growth factor-II (IGF-II) and insulin-like growth factor-binding protein 3 (IGF-BP3) in venous cord blood, and the levels of insulin, Cortisol and growth hormone (GH) in arterial cord blood of term neonates, and to search the effects of these factors on fetal growth. Material and Method: In this study, 82 term newborns (37 female, 45 male infants) born to healthy mothers, and their mothers were included. Anthropometric measurements of the cases, placental weight and weight gain of the mothers during pregnancy were all recorded. The levels of IGF-I, IGF-II, IGF-BP3, leptin, Cortisol, GH and insulin in cord blood were analyzed. Results: A significant correlation was found between IGF-I levels and birthweight (p<0.01; r=0.27), birth length (p<0.01; r=0.26) and placental weight (p0.01; r=0.32). In addition, a positive correlation was shown between cord blood leptin levels and birth weight (p<0.05; r=0.23), and body mass index (p<0.01; r=0.33). Apart from these, a significant correlation was found between placental weight and birth weight (p<0.001; r=0.80), birth length (p<0.001; r=0.62), head circumference (p<0.001; r=0.47) and body mass index (p<0.001; r=0.71). Additionally, a correlation was shown between venous cord blood leptin levels and arterial cord serum insulin levels (p<0.01; r=0.37). Through "Multiple Logistic Regression" analysis (MLR), parameters affecting the weight were shown as placental weight (MR=0.82), and leptin (MR=0.63) in decreasing order regarding MR values. It was noted that IGF-I, insulin and GH only slightly affected the birth weight. Using MLR analysis, it was found out that parameters affecting birth length were placental weight (r=0.47; MR=0.68), and leptin (r=0.16; MR=0.41), in decreasing order regarding MR values. Conclusion: The findings of this study supported the hypothesis that leptin and IGF-I levels in cord blood, and placenta regulate fetal growth. Fetal leptin levels seem to influence the regulation of fetal weight gain in contrast to fetal length. Insulin and leptin exhibit a positive interaction regarding fetal growth. Placenta is regarded as an endocrin organ, and it contributes significantly to the fetal growth through the factors it secrets. 41
Açıklama
Düzce Tıp Fakültesi, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
Anahtar Kelimeler
Çocuk Sağlığı ve Hastalıkları, Child Health and Diseases
