Abelmoschus esculentus Seed Ethanol Extract Protects Against Lipopolysaccharide-Induced Lung Injury in Rats through Anti-Inflammatory Properties

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dc.authorscopusid59288682100
dc.authorscopusid55624890100
dc.authorscopusid55881201300
dc.authorscopusid56841678200
dc.authorscopusid55552330200
dc.authorscopusid57188847187
dc.contributor.authorTirink, Omer Faruk
dc.contributor.authorBekdas, Mervan
dc.contributor.authorCetinkaya, Ayhan
dc.contributor.authorDuzcu, Selma Erdogan
dc.contributor.authorAlısık, Murat
dc.contributor.authorYoldas, Meyri Arzu
dc.date.accessioned2024-09-25T19:44:20Z
dc.date.available2024-09-25T19:44:20Z
dc.date.issued2023
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractBackground: Acute lung injury is respiratory failure due to various causes. Increased inflammatory and oxidative processes are recognized to play an essential role in the etiology of ARDS. Abelmoschus esculentus is an herbal product used to treat various diseases due to its anti-inflammatory and antioxidant effects. We aimed to investigate whether Abelmoschus esculentus has an effect on acute lung injury. Materials and Methods: In this experimental study, we used the ethanol extract of Abelmoschus esculentus seed. It divided forty male Wistar rats into five equal groups: 1) control, 2) Abelmoschus esculentus, 3) lipopolysaccharide, 4) lipopolysaccharide+Abelmoschus esculentus, and 5) lipopolysaccharide+ Abelmoschus esculentus +dexamethasone groups. Results: In the lipopolysaccharide group, native thiol, total thiol, IL-10, and IFN-? levels significantly changed. Abelmoschus esculentus was effective when used with dexamethasone in increasing native thiol and total thiol values (p=0.008 and p=0.004, respectively). On the other hand, when Abelmoschus esculentus was used alone, it significantly increased IL-10 levels and decreased IFN-? levels in the lipopolysaccharide group (p=0.025 and p<0.001, respectively). Additionally, improvements were noted in histological findings of alveolar congestion (p=0.006), intra-alveolar hemorrhage (p=0.006), and intra-alveolar macrophages (p=0.001). Conclusion: Abelmoschus esculentus, with its anti-inflammatory effect, may represent a new potential for treating acute lung injury. © 2023 NRITLD, National Research Institute of Tuberculosis and Lung Disease, Iran.en_US
dc.description.sponsorshipscientific research fund from Abant Izzet Baysal University, (2020.08.23.1466)en_US
dc.identifier.endpage425en_US
dc.identifier.issn1735-0344
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85201685353en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage418en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/12767
dc.identifier.volume22en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherShaheed Beheshti University of Medical Sciences and Health Servicesen_US
dc.relation.ispartofTanaffosen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzYK_20240925en_US
dc.subjectAbelmoschus esculentusen_US
dc.subjectAcute Lung Injuryen_US
dc.subjectIFN-?en_US
dc.subjectIL-10en_US
dc.subjectThiolen_US
dc.titleAbelmoschus esculentus Seed Ethanol Extract Protects Against Lipopolysaccharide-Induced Lung Injury in Rats through Anti-Inflammatory Propertiesen_US
dc.typeArticleen_US

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