Residual thiosulfate determination in omeprazole by liquid chromatography
Yükleniyor...
Dosyalar
Tarih
2016
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Acg Publications
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
An HPLC-UV method for the determination of thiosulfate in aqueous media was modified and validated in this study to quantify the amount of residual thiosulfate in omeprazole samples. Absorption of thiosulfate ion was monitored at 215 nm in alcoholic tetrabutylammonium hydroxide solution as a mobile phase, in which the pH was adjusted to 6.20 by using dilute hydrochloric acid. A method detection limit of 0.08 mg/L was achieved for thiosulfate ion in 1000 mg/L omeprazole solution. The precision, accuracy, and the expanded uncertainty of the method were 2.7 %, 92.4-102.6 %, and 2.2 % (at 95 % confidence level (k = 2) assuming 1.0 mg/L thiosulfate in the sample solution), respectively.
Açıklama
Anahtar Kelimeler
HPLC-UV, Omeprazole, Residual Thiosulfate, Method Validation
Kaynak
Journal Of Chemical Metrology
WoS Q Değeri
N/A
Scopus Q Değeri
Cilt
10
Sayı
2
