The Anti-Convulsant Effects of Carvacrol in Penicillin- and Pentylenetetrazole-Induced Rat Models of Epilepsy

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dc.contributor.authorEksik, Handan
dc.contributor.authorAnkarali, Seyit
dc.contributor.authorTorun, Ibrahim Ethem
dc.contributor.authorKilinc, Erkan
dc.contributor.authorAnkarali, Handan
dc.date.accessioned2024-09-25T19:57:24Z
dc.date.available2024-09-25T19:57:24Z
dc.date.issued2024
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractEpileptic seizures are caused by abnormal neuronal excitation. It is well established that carvacrol, a monoterpenoid phenol, is able to inhibit the voltage-gated sodium channels and L-type Ca2+ channels and enhance activation of GABA(A) receptors. We therefore hypothesize that carvacrol may prevent epileptic seizures by inhibiting neuronal cation influx and facilitating anion influx. Herein, we investigated possible anti-convulsant effects of carvacrol on penicillin-induced epileptiform activity and pentylenetetrazole (PTZ)-induced seizures in rats. 63 male Wistar rats were assigned to the penicillin- and the pentylenetetrazole-induced groups. Both subgroups received three different doses of carvacrol (25, 75, and 150 mg/kg) intraperitoneally. Seizure stage, onset-times of both myoclonic-jerk and generalized tonic-clonic seizures and the duration of generalized tonic-clonic seizure were evaluated using Racine's scale in PTZ group, while spike frequency and the amplitude of epileptiform discharges were evaluated in the penicillin-induced group. The administration of carvacrol significantly extended the onset time of the first myoclonic jerk (150 mg/kg, p = 0.019) and decreased the number of spike-waves (75 mg/kg, p = 0.033). This study showed that carvacrol has the anti-convulsant effect. However, this effect was observed at a low level. The limited the anti-convulsant effect of carvacrol may be due to its insufficient of acute effect related to the transition of carvacrol to the epileptic focus. More studies are needed to evaluate the effect of carvacrol on chronic epilepsy models and its molecular and pharmacokinetic mechanisms.en_US
dc.identifier.doi10.1134/S181971242402003X
dc.identifier.endpage305en_US
dc.identifier.issn1819-7124
dc.identifier.issn1819-7132
dc.identifier.issue2en_US
dc.identifier.startpage296en_US
dc.identifier.urihttps://doi.org/10.1134/S181971242402003X
dc.identifier.urihttps://hdl.handle.net/20.500.12491/13379
dc.identifier.volume18en_US
dc.identifier.wosWOS:001233389200008en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherMaik Nauka/Interperiodica/Springeren_US
dc.relation.ispartofNeurochemical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzYK_20240925en_US
dc.subjectcarvacrolen_US
dc.subjectanti-convulsanten_US
dc.subjectseizureen_US
dc.subjectpenicillinen_US
dc.subjectpentylenetetrazoleen_US
dc.titleThe Anti-Convulsant Effects of Carvacrol in Penicillin- and Pentylenetetrazole-Induced Rat Models of Epilepsyen_US
dc.typeArticleen_US

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