The therapeutic effects of etanercept-methotrexate combination on experimental spinal cord injury

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dc.authorscopusid6602531317
dc.authorscopusid57192926677
dc.authorscopusid26024651100
dc.authorscopusid55246891700
dc.authorscopusid56857485400
dc.authorscopusid35356400800
dc.authorscopusid14061002000
dc.contributor.authorGezici, Ali Riza
dc.contributor.authorAkar, Semih
dc.contributor.authorFirat, Tulin
dc.contributor.authorDagistan, Yasar
dc.contributor.authorCancan, Seckin Emre
dc.contributor.authorKukner, Aysel
dc.contributor.authorOzkan, Nezih
dc.date.accessioned2024-09-25T19:45:16Z
dc.date.available2024-09-25T19:45:16Z
dc.date.issued2017
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractBackground: Experimental studies have demonstrated that neurons keep dying in an unrecoverable and non-regenerative pattern in following hours after primary mechanical injury to spinal cord. The cascade of events which is called secondary injury is composed of vascular impairment, oedema, ischemia, inflammation, exotoxicity, electrolyte imbalance, lipid peroxidation, free radicals, necrosis and apoptotic cell death. Aims: With clinical and histopathological tests, this study investigated the therapeutic effects of etanercept-methotrexate combination which is an option in mono-therapy resistant rheumatological diseases; but this combination has not been used on recovery processes in clip compression Spinal Cord Injury (SCI) model yet. Study design: Forty Spraque-Dawley rats were divided into five groups: group 1 (Sham-control), group 2 (SCI+2 ml saline intramuscular), group 3 (SCI+1.25 mg/kg etanercept), group 4 (SCI+0.5 mg/kg methotrexate) and group 5 (SCI+1.25 mg/kg etanercept+0.5 mg/kg methotrexate). Methods: Rats were evaluated 1st, 3rd, 5th and 10th days after SCI, clinically by Drummond and Moore scale, under light microscopy and by Tunel test; after sacrification on 10th day. Results: Clinical and histopathological results of all treatment groups were found significantly better than the results of the trauma group; also no superiority in the monotherapy groups, over each other, was noted. Conclusion: Combined-treatment group had a statistically significant better outcome in preventing apoptosis, but there was no difference according to the clinical results. © 2017, Scientific Publishers of India. All rights reserved.en_US
dc.identifier.endpage2192en_US
dc.identifier.issn0970-938X
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-85015765380en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage2185en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/12933
dc.identifier.volume28en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherScientific Publishers of Indiaen_US
dc.relation.ispartofBiomedical Research (India)en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzYK_20240925en_US
dc.subjectEtanercepten_US
dc.subjectMethotrexateen_US
dc.subjectSpinal cord injuryen_US
dc.titleThe therapeutic effects of etanercept-methotrexate combination on experimental spinal cord injuryen_US
dc.typeArticleen_US

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