Diabetes mellitus increases plasma cardiothrophin-1 levels independently of heart failure and hypertension

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dc.authorscopusid54382735700
dc.authorscopusid16835837300
dc.authorscopusid10039968300
dc.authorscopusid9246515100
dc.authorscopusid14013992100
dc.authorscopusid6603937352
dc.authorscopusid7007162316
dc.contributor.authorAktas, Gulal
dc.contributor.authorAlcelik, Aytekin
dc.contributor.authorTosun, Mehmet
dc.contributor.authorOzturk, Serkan
dc.contributor.authorOzlu, Mehmet Fatih
dc.contributor.authorSavli, Haluk
dc.contributor.authorYazici, Mehmet
dc.date.accessioned2024-09-25T19:43:04Z
dc.date.available2024-09-25T19:43:04Z
dc.date.issued2013
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractAims: Cardiothrophin-1 (CT-1) is a novel 201 amino acid cytokine that has pleiotropic protective effects in apoptosis, hepatic injury, myocardial infection and contrast nephropathy. CT-1 predicts a variety of disorders including atherosclerosis, heart failure, hypertension and cardiomyopathy. However, CT-1 has not been studied previously in diabetic patients without heart failure. The aim of this study was, therefore, to compare CT-1 levels in diabetic and non-diabetic patients. Methods: Thirty-eight patients with type 2 diabetes mellitus and 32 non-diabetic controls have been enrolled into the study. Subjects with severe hypertension, renal diseases, pregnancy and malignancy were excluded. The statistical analysis was performed with SPSS for Windows version 15.0. Results: There were no significant differences between the diabetic and non-diabetic groups with regard to age, hypertension, serum creatinine, systolic and diastolic blood pressure. Median plasma CT-1 was 9.05 (5.70-24.94) pg/ml in diabetic group and 7.16 (5.53-9.64) pg/ml in non-diabetic group (P <0.001). Conclusion: Plasma CT-1 levels increased in diabetic patients independently of hypertension (HT) and heart failure. Prospective studies with a larger cohort are now needed to observe the effects of CT-1 treatment in a diabetic population.en_US
dc.identifier.endpage784en_US
dc.identifier.issn0393-6384
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-84896737060en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage781en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/12408
dc.identifier.volume29en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherActa Medica Mediterraneaen_US
dc.relation.ispartofActa Medica Mediterraneaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzYK_20240925en_US
dc.subjectCardiothrophin-1en_US
dc.subjectDiabetes mellitusen_US
dc.subjectHeart failureen_US
dc.subjectHypertensionen_US
dc.titleDiabetes mellitus increases plasma cardiothrophin-1 levels independently of heart failure and hypertensionen_US
dc.typeArticleen_US

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