Protein pieces of adipose tissue secretory puzzle

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dc.authorid0000-0001-5912-9392
dc.contributor.authorTöre, Fatma
dc.contributor.authorTunçel, Neşe
dc.date.accessioned2021-06-23T18:54:12Z
dc.date.available2021-06-23T18:54:12Z
dc.date.issued2007
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractOver the past decade, the paradigm shift of adipose tissue as being far beyond its pivotal role in lipid and energy homeostasis has been increasingly recognized. Arguably, adipocytes as well as other adipose cells are at present considered bona fide secretory cell types, using pleiocrine pathways for delivery of multiple signaling proteins designated adipokines. Transcriptomic and proteomic studies "upregulate" more than hundred adipokines that are synthesized, stored, and released by adipose tissue cells. However, the functional description of adipose-secreted proteins look like an incomplete puzzle. Here we describe only adipsin, adiponectin, leptin, resistin, visfatin, tumor necrosis factor-alpha, interleukin-6, plasminogen activator inhibitor type 1, nerve growth factor, brain-derived neurotrophic factor, and metallothioneins, and focus on their implications for the pathogenesis of various diseases besides obesity and related disorders. Accordingly, a horizon of the adipopharmacology of disease is outlined. © Bulgar ian Society for Cell Biology.en_US
dc.identifier.doi10.14748/bmr.v18.66
dc.identifier.endpage43en_US
dc.identifier.issn1310-392X
dc.identifier.scopus2-s2.0-78249281992en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage27en_US
dc.identifier.urihttps://doi.org/10.14748/bmr.v18.66
dc.identifier.urihttps://hdl.handle.net/20.500.12491/4300
dc.identifier.urihttps://journals.mu-varna.bg/index.php/bmr/article/view/66/66
dc.identifier.volume18en_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorTöre, Fatma
dc.language.isoenen_US
dc.publisherBulgarian-American Centeren_US
dc.relation.ispartofBiomedical Reviewsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAdipokinesen_US
dc.subjectAtherosclerosisen_US
dc.subjectCardiometabolic Diseasesen_US
dc.subjectInflammationen_US
dc.subjectObesityen_US
dc.titleProtein pieces of adipose tissue secretory puzzleen_US
dc.typeArticleen_US

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