Is circulating survivin altered in acromegaly?

Basit Öğe Kaydı
dc.authorid0000-0001-7507-2808
dc.authorid0000-0001-7646-7852
dc.authorid0000-0003-4796-8425
dc.contributor.authorAdemoğlu, Esra
dc.contributor.authorDilekçi, Erdal
dc.contributor.authorCandan, Zehra
dc.contributor.authorGorar, Suheyla
dc.contributor.authorNiyazoğlu, Mutlu
dc.date.accessioned2021-06-23T18:34:11Z
dc.date.available2021-06-23T18:34:11Z
dc.date.issued2018
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractAcromegaly is a chronic disorder which is characterized by growth hormone (GH) excess. In most of cases, GH hypersecretion is derived from somatotroph cell tumors. Survivin is a member of apoptosis protein family, which was recently showed to be expressed in tissue samples of different benign and malignant human tumors. This study is intended to determine circulating levels of survivin in newly diagnosed acromegaly patients with somatotroph adenomas. 19 newly diagnosed acromegaly patients with somatotroph adenomas were inclu-ded in the study. Concurrently, 19 healthy individuals were included as control group. Serum survivin levels, GH, insulin like growth factor-1 (IGF-1) and, some other biochemical parame-ters as fasting glucose, creatinine, alanine aminotransferase, cholesterol, triglyceride, high den-sity lipoprotein cholesterol, low density lipoprotein cholesterol were measured in each subject. Correlation analysis was performed between survivin and GH, IGF-1. Serum survivin levels tended to be higher in acromegaly group, but this was not reach statistical significance (p>0.05). Serum survivin levels were comparable among acromegaly patients and controls. Neither GH nor IGF-1 correlated with serum survivin. Larger scale studies are needed concerning the circulating levels of survivin in patients with acromegaly.en_US
dc.identifier.doi10.5455/medscience.2017.06.8681
dc.identifier.endpage268en_US
dc.identifier.issn2147-0634
dc.identifier.issn2147-0634
dc.identifier.issue2en_US
dc.identifier.startpage265en_US
dc.identifier.trdizinid308575en_US
dc.identifier.urihttps://doi.org/10.5455/medscience.2017.06.8681
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TXpBNE5UYzFOUT09
dc.identifier.urihttps://hdl.handle.net/20.500.12491/2431
dc.identifier.volume7en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorAdemoğlu, Esra
dc.institutionauthorDilekçi, Erdal
dc.language.isoenen_US
dc.relation.ispartofMedicine Scienceen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcromegaly
dc.subjectSurvivin
dc.subjectApoptosis Protein Family
dc.titleIs circulating survivin altered in acromegaly?en_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
esra-ademoglu.pdf
Boyut:
361.98 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam metin/ Full text
İndir

Koleksiyon

TR-Dizin İndeksli Yayınlar Koleksiyonu
Dahili Tıp Bilimleri Bölümü Koleksiyonu