Atypical antipsychotic use is an independent predictor for the increased mean platelet volume in patients with schizophrenia: A preliminary study

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dc.authorscopusid36523944500
dc.authorscopusid35886196700
dc.authorscopusid6508025716
dc.authorscopusid57218584302
dc.authorscopusid35222549900
dc.authorscopusid7202595585
dc.authorscopusid8289955800
dc.contributor.authorSemiz, Murat
dc.contributor.authorYücel, Hasan
dc.contributor.authorKavakçi, Önder
dc.contributor.authorYildirim, Osman
dc.contributor.authorZorlu, Ali
dc.contributor.authorYilmaz, Mehmet Birhan
dc.contributor.authorKüçükdurmaz, Zekeriya
dc.date.accessioned2024-09-25T19:44:20Z
dc.date.available2024-09-25T19:44:20Z
dc.date.issued2013
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractBackground: Cardiovascular diseases, cardiovascular risk factors, and mortality due to these situations are more frequently encountered in schizophrenic patients when compared with the general population. The mean platelet volume (MPV) is a surrogate biomarker of the platelet activity and an useful prognostic test in cardiometabolic diseases. The aim of this study was to investigate what influenced MPV levels in patients with schizophrenia. Materials and Methods: We evaluated hospital records of 60 hospitalized schizophrenia patients. Thirty age- and sex-matched healthy control subjects were also included as a control group. Results: MPV levels were significantly higher in patients who were on atypical antipsychotic drugs than in patients who were not using any drug (9.2 ± 0.8 vs. 8.6 ± 0.8 fL, P = 0.016) and also higher than control group (9.2 ± 0.8 vs. 8.1 ± 0.9 fL, P < 0.001). Furthermore, patients who were not using antipsychotics had higher MPV than control group (8.6 ± 0.8 vs. 8.1 ± 0.9 fL, P = 0.036). Atypical antipsychotic use [Odds ratio (OR) =6.152, 95% confidence interval (CI,) P = 0.003)] and platelet distribution width (OR = 0.989, 95% CI, P = 0.032) were associated with high MPV levels in univariate analysis. In multivariate logistic regression model, only atypical antipsychotics use (OR = 6.152, 95% CI, P = 0.003) was found to be independent predictor of high MPV levels after adjustment of other potential confounders (age, gender, presence of hypertension, diabetes mellitus, hyperlipidemia, and smoking). Conclusion: MPV seems to be influenced not only by schizophrenia itself but also by atypical antipsychotic drugs. It might be concluded that schizophrenic patients are under increased risk for cardiometabolic diseases and risk factors and this risk is higher in patients on atypical antipsychotic treatment.en_US
dc.identifier.endpage565en_US
dc.identifier.issn1735-7136
dc.identifier.issue7en_US
dc.identifier.scopus2-s2.0-84883007543en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage560en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/12769
dc.identifier.volume18en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofJournal of Research in Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzYK_20240925en_US
dc.subjectAtypical antipsychoticsen_US
dc.subjectCardiovascular diseaseen_US
dc.subjectMean platelet volumeen_US
dc.subjectSchizophreniaen_US
dc.titleAtypical antipsychotic use is an independent predictor for the increased mean platelet volume in patients with schizophrenia: A preliminary studyen_US
dc.typeArticleen_US

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