Subanesthetic concentration of sevoflurane and desflurane were inhalated in rats; Liver and kidney toxicities and behavioural effects

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dc.authorscopusid14629549000
dc.authorscopusid6505842146
dc.authorscopusid8521302200
dc.authorscopusid59081644500
dc.contributor.authorSezen, Gülbin
dc.contributor.authorDemiraran, Yavuz
dc.contributor.authorKocaman, Buket
dc.contributor.authorAksoy, K. Aylin
dc.date.accessioned2024-09-25T19:44:08Z
dc.date.available2024-09-25T19:44:08Z
dc.date.issued2007
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractAim: Numerous studies have suggested that chronic exposure to trace levels of anesthetic gas is harmful to operating room personel. In this study, we aimed to the effects of subanesthetic doses of sevoflurane and desflurane on anxiety and hepatic and renal toxicities according to biochemical and histopathological changes in rats. Material and Methods: Total 24 rats were included study and three groups were formed as sevoflurane (% 0.1), desflurane (% 0.04) and control (3 L min -1 O 2). During four months, every day between 09.00-13.00 hours in the morning were inhaled with anesthetic agent determined concentrations. Anxiety were examined with Plus Maze Test; pre and post study urea, BUN, creatinine and GGT were examined in blood supplies. At the end of the study, rats were sacrificed for examined of kidney and liver histopathologically. Results: In the sevoflurane and desflurane groups increased the time spent within the closed pathways without motion. In the sevoflurane group; GGT, urea and BUN levels were elevated significantly. In the sevoflurane and desflurane groups hepatic congestion were examined significantly increased more than control group, focal necrosis increased in the sevoflurane group more than others. In the sevofluran group; focal lymphocytic infiltration and flatting in the tubuler epithelium were examined significantly higher than other groups. Conclusion: Our results were examined, subanesthetic doses of sevoflurane and desflurane were used increased to anxiety, caused of renal and hepatic damage at subclinic levels in rats.en_US
dc.identifier.endpage89en_US
dc.identifier.issn1304-0871
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-34547341020en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage83en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/12653
dc.identifier.volume35en_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.relation.ispartofTurk Anesteziyoloji ve Reanimasyon Dernegi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzYK_20240925en_US
dc.subjectAnxietyen_US
dc.subjectDesfluraneen_US
dc.subjectRaten_US
dc.subjectSevofluraneen_US
dc.subjectToxicityen_US
dc.titleSubanesthetic concentration of sevoflurane and desflurane were inhalated in rats; Liver and kidney toxicities and behavioural effectsen_US
dc.title.alternativeSubanestezik konsantrasyonlarda solutulan desfluran ve sevofluranin siçanlarda; karaci?er ve böbrek toksisitesi ile davranişlari üzerine etkileri]en_US
dc.typeArticleen_US

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