The effect of intra-amygdalar leptin administration on anxiety, depression and learning behaviors in rats

Basit Öğe Kaydı
dc.authorscopusid57219390008
dc.authorscopusid57189842131
dc.authorscopusid8711250100
dc.authorscopusid26658294000
dc.contributor.authorSoytürk, Hayriye
dc.contributor.authorBozat, Bihter Gökçe
dc.contributor.authorCoşkun, Hamit
dc.contributor.authorKarakaş, Fatma Pehlivan
dc.date.accessioned2024-09-25T19:44:12Z
dc.date.available2024-09-25T19:44:12Z
dc.date.issued2021
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractLeptin is released by adipose tissue. Leptin can cross the blood-brain barrier and bind to receptors on neurons in brain areas to exert its biological function when released into circulation. This study aimed to determine the influences of intra-amygdalar administration of high and low doses of leptin on anxiety, depression, learning behaviors of rats. In the experimental protocol I, intra-amygdalar injection of high and low doses of leptin (0.1 and 1?g/ kg) and saline were administered 30 min before the behavioral tests. Then, the animals were exposed to open field, elevated plus maze, Porsolt and Morris water maze tests for measuring of behaviors. In experimental protocol 2, the cerebrospinal fluids of all groups of experimental protocol 1 were collected by microdialysis method and then were analyzed by HPLC. The effect of the low dose of leptin was significant on the open field. The effect of the high and low dose of leptin was significant on the elevated plus maze test. The effect of the low dose of leptin was significant on mobility in the center of the Porsolt. A high dose of leptin group had spent less time around the platform than controls in the Morris water maze test. HPLC analysis showed that the amount of serotonin and glutamate in the amygdala region increased after low dose leptin administration. Intra-amygdalar injection of low doses of leptin may decrease anxiety and depression-like behavior in rats by increasing serotonin and glutamate levels in the amygdala. © 2021 Ondokuz Mayis Universitesi. All rights reserved.en_US
dc.description.sponsorshipAbant Izzet Baysal University Research Foundation, (2012.03.01.504); Department of Biology, Bolu Abant Izzet Baysal University; British Association for Psychopharmacology, BAPen_US
dc.identifier.doi10.52142/omujecm.38.3.24
dc.identifier.endpage335en_US
dc.identifier.issn1309-4483
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85105280498en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage331en_US
dc.identifier.urihttps://doi.org/10.52142/omujecm.38.3.24
dc.identifier.urihttps://hdl.handle.net/20.500.12491/12717
dc.identifier.volume38en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherOndokuz Mayis Universitesien_US
dc.relation.ispartofJournal of Experimental and Clinical Medicine (Turkey)en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzYK_20240925en_US
dc.subjectAmygdalaen_US
dc.subjectAnxietyen_US
dc.subjectBehavioren_US
dc.subjectDepressionen_US
dc.subjectLeptinen_US
dc.titleThe effect of intra-amygdalar leptin administration on anxiety, depression and learning behaviors in ratsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu