Analysis of Antioxidant Effects of Lycopene and Caffeine in Experimentally Induced Renal Ischemia-Reperfusion Injury in Rats

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dc.contributor.authorSaylan, Aslihan
dc.contributor.authorFirat, Tülin
dc.contributor.authorYis, Özgür Mehmet
dc.contributor.authorDede, Gizem
dc.contributor.authorCarver, Hande
dc.date.accessioned2024-09-25T20:19:55Z
dc.date.available2024-09-25T20:19:55Z
dc.date.issued2021
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractBackground: The aim was to investigate the antioxidant effects of lycopene and caffeine in rats exposed to renal ischemia/reperfusion (IR) injury. Materials and Methods: Following right renal nephrectomy, 60 minutes of ischemia followed by 60 minutes of reperfusion were performed in 200-250 gram Wistar albino rats used in the study. 30 minutes before ischemia, lycopene (5 mg/kg), caffeine (50 mg/kg), lycopene (5 mg/kg) + caffeine (50 mg/kg) were adminis- tered intraperitoneally to the rats. After the experiment, 4 ml of blood and left kidney were taken from the rats. Tissue malondialdehyde (MDA), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) and se- rum creatinine activities were measured biochemically and light microscopy findings were evaluated histo- logically. Results: When MDA levels are compared; Although the MDA level of the IR+Lycopene group was lower than the IR group, no significance was observed. When IR+Lycopene and IR+Caffeine groups are compared; The MDA level of the IR+Lycopene group is higher than the IR+ Caffeine group. In the IR+Caffeine group; A sta- tistically significant increase was observed in serum creatinine compared to the IR+Lycopene+Caffeine group. Although SOD and GSH-Px were higher in the antioxidant groups compared to the IR group, no sta- tistically significant difference was observed. When compared with ischemia-reperfusion group, histopatho- logical damage was found to be significantly lower than in the other groups. It was found that Lycopene and Caffeine reduced apoptosis, tubular dilatation, tubular epithelium degeneration, glomerular shrinkage, des- quame epithelium and proteinous cast amount significantly. Conclusions: While lycopene has high antioxidant efficiency when compared with caffeine, lycopene and caffeine have protective effect against renal ischemia reperfusion injury.en_US
dc.identifier.doi10.35440/hutfd.865165
dc.identifier.endpage516en_US
dc.identifier.issn1304-9623
dc.identifier.issn1309-4025
dc.identifier.issue3en_US
dc.identifier.startpage510en_US
dc.identifier.trdizinid1134300en_US
dc.identifier.urihttps://doi.org/10.35440/hutfd.865165
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1134300
dc.identifier.urihttps://hdl.handle.net/20.500.12491/15845
dc.identifier.volume18en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofHarran Üniversitesi Tıp Fakültesi Dergisien_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzYK_20240925en_US
dc.subjectKidneyen_US
dc.subjectIschemia/Reperfusion Injuryen_US
dc.subjectLycopeneen_US
dc.subjectCaffeineen_US
dc.titleAnalysis of Antioxidant Effects of Lycopene and Caffeine in Experimentally Induced Renal Ischemia-Reperfusion Injury in Ratsen_US
dc.typeArticleen_US

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