The effect of intrarectal paclitaxel lavage on the healing of rectal anastomosis: A comparison with povidone iodine

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dc.authorscopusid6603565782
dc.authorscopusid15727591200
dc.authorscopusid9280121300
dc.contributor.authorGünal, Ömer
dc.contributor.authorGhandouri, Salah
dc.contributor.authorAslaner, Arif
dc.date.accessioned2024-09-25T19:43:17Z
dc.date.available2024-09-25T19:43:17Z
dc.date.issued2005
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractObjective: Intraluminal colonic washout with anticancer agents is an alternative option to prevent local recurrences after colorectal cancer resection. However, intracolonic washout with any agent can interfere with anastomotic wound healing. The current study aimed to investigate the effects of intracolonic paclitaxel and povidone-iodine administration on intestinal anastomotic healing. Material and Methods: Localized intracolonic washout with paclitaxel (3 mg/kg) and povidone-iodine (5%) was achieved before and after colorectal anastomosis in two (each consisting of 10) groups of rats. The control group (n= 10) received no medical therapy. Anastomotic bursting pressures, anastomotic hydroxyproline content, and peri-anastomotic myeloperoxidase activity were determined. Results: Bursting pressure was significantly less in the povidone group, while it was slightly elevated in the paclitaxel group when compared to the control group. The hydroxyproline level was significantly increased in the povidone group, while it was found to be decreased in the paclitaxel group. Myeloperoxidase levels were also significantly decreased in both groups when compared to the control group. Conclusion: Although paclitaxel decreases hydroxyproline production, it does not appear to affect anastomotic bursting pressure. Conversely, povidone-iodine decreases anastomotic bursting pressure despite increased hydroxproline synthesis. These data imply that paclitaxel and povidone-iodine carry out their effects on anastomotic healing either by altering the quality or quantity of collagen synthesis. Copyright © 2005 by Türkiye Klinikleri.en_US
dc.identifier.endpage657en_US
dc.identifier.issn1300-0292
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-27844593726en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage653en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/12508
dc.identifier.volume25en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTurkiye Kliniklerien_US
dc.relation.ispartofTurkiye Klinikleri Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzYK_20240925en_US
dc.subjectColonen_US
dc.subjectPaclitaxelen_US
dc.subjectPovidone-iodineen_US
dc.titleThe effect of intrarectal paclitaxel lavage on the healing of rectal anastomosis: A comparison with povidone iodineen_US
dc.typeArticleen_US

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