Pathophysiology of Chronic Rhinosinusitis with Nasal Polyps

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dc.authorscopusid57006788200
dc.authorscopusid8729462700
dc.authorscopusid7006913109
dc.authorscopusid57194214668
dc.contributor.authorBoztepe, Fatih
dc.contributor.authorUral, Ahmet
dc.contributor.authorPaludetti, Gaetano
dc.contributor.authorDe Corso, Eugenio
dc.date.accessioned2024-09-25T19:45:36Z
dc.date.available2024-09-25T19:45:36Z
dc.date.issued2019
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractChronic rhinosinusitis (CRS) is defined the following way in the 2012 EPOS guidelines: nasal and paranasal sinus inflammation lasting a minimum of 12 weeks, plus at least two of the following features: blocked nose, rhinorrhoea, pain or pressure sensation over the face, hyposmia or anosmia. According to this guideline, at a minimum, the nose should be obstructed or there must be nasal drip anteriorly or posteriorly to qualify for the diagnosis. This clinical diagnosis can then be confirmed objectively through CT scanning of the sinuses or nasal endoscopy, which also permits characterisation as chronic rhinosinusitis with or without nasal polyp formation (CRSsNP and CRSwNP, respectively). Polyps characteristically contain elevated levels of IL-5 and IL-13, produced by T-helper 2 cells, as well as histamine. Through the endoscope, polyps take on a translucent, glistening appearance, with a colour between yellowish-grey and white, and are seen to contain abundant inflammatory debris of a gelatinous consistency. They arise from the mucosal linings of the nasal sinuses or the nose itself. They are particularly frequent at the ostia of the sinuses. Due to being poorly vascularised, polyps have a greyish-white appearance. It is fairly uncommon to find polyp formation confined unilaterally, despite the occurrence of a sole polyp on occasion at the middle meatus or the posterior recess of the sphenoethmoid. Polyps which form unilaterally may exhibit a difference in appearance and are a suspicious feature for inverting papilloma, fungal infection or a neoplasm. Combining sinusal CT with MRI is often beneficial diagnostically. A confirmation of unilaterality through imaging should make the clinician evaluate other possible diagnoses. Pathophysiology of chronic rhinosinusitis with nasal polyps is presented. © Springer Nature Switzerland AG 2020.en_US
dc.identifier.doi10.1007/978-3-030-21217-9_43
dc.identifier.endpage379en_US
dc.identifier.isbn978-303021217-9
dc.identifier.isbn978-303021216-2
dc.identifier.scopus2-s2.0-85152339594en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage373en_US
dc.identifier.urihttps://doi.org/10.1007/978-3-030-21217-9_43
dc.identifier.urihttps://hdl.handle.net/20.500.12491/13109
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringer International Publishingen_US
dc.relation.ispartofAll around the Nose: Basic Science, Diseases and Surgical Managementen_US
dc.relation.publicationcategoryKitap Bölümü - Uluslararasıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzYK_20240925en_US
dc.subjectChronic rhinosinusitis with nasal polypsen_US
dc.subjectIL-13en_US
dc.subjectIL-5en_US
dc.subjectNasal endoscopyen_US
dc.subjectPathophysiologyen_US
dc.titlePathophysiology of Chronic Rhinosinusitis with Nasal Polypsen_US
dc.typeBook Chapteren_US

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