Gestasyonel diabetes mellitusta ortalama trombosit hacmi düzeylerindeki değişim
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Tarih
2016
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Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
GİRİŞ ve AMAÇ: Ortalama trombosit hacmi (OTH) trombositlerin ortalama büyüklüklerini gösteren bir laboratuvar parametresidir. Literatürde, kronik inflamasyonla seyreden hastalıklarda OTH'nin azaldığı ve inflamasyon göstergelerinden biri olduğu bildirilmektedir. Gestasyonel diabetes mellitus (GDM) gibi proinflamatuvar ve proaterojenik riskin yüksek olduğu klinik bir durumda OTH düzeylerini incelemek bu çalışmanın temel amacını oluşturmaktadır. Ayrıca, OTH'nin çeşitli hematolojik ve biyokimyasal parametrelerle de korelasyonu incelenmiş ve OTH'nin GDM gelişimi açısından bir risk faktörü olup olmadığı araştırılmıştır. YÖNTEM ve GEREÇLER: Gebeliğinin 24. ve 28. haftaları arasında yeni tanı konulan 43 GDM'li kadın hasta ile 35 sağlıklı gebe kontrol grubunun verileri analiz edildi. BULGULAR: GDM'li grupta trombosit sayısı kontrol grubuna göre anlamlı olarak daha yüksek seviyelerde saptanırken (p=0.013), OTH değerleri anlamlı düzeyde daha düşük olarak tespit edildi (p=0.010). Bivariate analizlerde OTH ile trombosit sayısı arasında negatif ilişki bulundu (p=0.001, r=- 0.88). GDM gelişimi açısından, açlık kan şekeri (p=0.008) ve vücut kitle indeksi (VKİ) yüksekliğinin (p=0.04) yanı sıra OTH düşüklüğü (p=0.027) bağımsız prediktörler olarak tespit edildi. SONUÇ: Çalışmamızda OTH, GDM grubunda sağlıklı gebe grubuna göre düşük bulundu ve gestasyonel diyabet gelişimi açısından OTH düşüklüğü bağımsız bir risk faktörü olarak tespit edildi.
INTRODUCTION: Mean platelet volume (MPV) is a laboratory parameter which shows the average size of platelets. In the literature, MPV has been reported to decrease in some diseases associated with inflammation and considered one indicator of inflammation. The main objective of this study is to investigate the MPV in gestational diabetes mellitus (GDM) as a clinical condition characterized with increased proinflammatory and proatherogenic risk. In addition, the correlation of MPV with various hematologic and biochemical parameters have also been assessed, and whether MPV is a risk factor for the development of GDM has been examined. MATERIALS and METHODS: Datas of 43 women newly diagnosed with GDM at 24-28 weeks of gestation and 35 healthy pregant women were analyzed. RESULTS: Platelet counts were found to be significantly higher in gestational diabetes group compared to controls (p=0.013) while MPV was significantly found to be lower(0.010). A negative correlation was found between MPV and platelet count in bivariate analysis (p=0.001, r=-0.88). Low MPV (p= 0.027) as well as fasting blood glucose (p=0.008) and BMI (p=0.04), were found to be independent predictors for the development of GDM. CONCLUSION: MPV was found to be lower in GDM group compared to healty pregnant individuals and was determined to be an independent risk factor for development of gestational diabetes mellitus.
INTRODUCTION: Mean platelet volume (MPV) is a laboratory parameter which shows the average size of platelets. In the literature, MPV has been reported to decrease in some diseases associated with inflammation and considered one indicator of inflammation. The main objective of this study is to investigate the MPV in gestational diabetes mellitus (GDM) as a clinical condition characterized with increased proinflammatory and proatherogenic risk. In addition, the correlation of MPV with various hematologic and biochemical parameters have also been assessed, and whether MPV is a risk factor for the development of GDM has been examined. MATERIALS and METHODS: Datas of 43 women newly diagnosed with GDM at 24-28 weeks of gestation and 35 healthy pregant women were analyzed. RESULTS: Platelet counts were found to be significantly higher in gestational diabetes group compared to controls (p=0.013) while MPV was significantly found to be lower(0.010). A negative correlation was found between MPV and platelet count in bivariate analysis (p=0.001, r=-0.88). Low MPV (p= 0.027) as well as fasting blood glucose (p=0.008) and BMI (p=0.04), were found to be independent predictors for the development of GDM. CONCLUSION: MPV was found to be lower in GDM group compared to healty pregnant individuals and was determined to be an independent risk factor for development of gestational diabetes mellitus.
Açıklama
Anahtar Kelimeler
Ortalama Trombosit Hacmi (OTH), Gestasyonel Diabetes Mellitus, Trombosit, Mean Platelet Volume (MPV), Gestational Diabetes Mellitus, Platelet
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Cilt
5
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3