Thiol-Disulfide Balance in Fibromyalgia: A Case-Control Study

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dc.authoridOgus, Elmas/0000-0003-3844-2173
dc.authoridDemir Karakilic, Gulseren/0000-0003-1292-0835
dc.authoridEREL, Ozcan/0000-0002-2996-3236
dc.authoridSahingoz Bakirci, Esra/0000-0002-4610-0440
dc.authoridBuyuk, Ferda/0000-0003-3748-3109
dc.authoridAlisik, Murat/0000-0003-0434-3206
dc.contributor.authorBakirci, Esra Sahingoz
dc.contributor.authorNacir, Baris
dc.contributor.authorAlisik, Murat
dc.contributor.authorGenc, Hakan
dc.contributor.authorOgus, Elmas
dc.contributor.authorKarakilic, Gulseren Demir
dc.contributor.authorBuyuk, Ferda
dc.date.accessioned2024-09-25T19:57:39Z
dc.date.available2024-09-25T19:57:39Z
dc.date.issued2024
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractAim. We aimed to examine the thiol-disulfide (SS) balance, a recognized marker of oxidative stress, fibromyalgia syndrome (FMS). Methods. The study comprised 98 female participants (61 newly diagnosed patients and 37 patients under treatment) with FMS, along with 82 apparently healthy female volunteers. In both groups, assessments were conducted using the Fibromyalgia Impact Questionnaire (FIQ), Visual Analogue Scale (VAS), Pittsburgh Sleep Quality Index (PSQI), Fatigue Severity Scale (FSS), Short Form -36 (SF -36), Tender Point Count, Beck Depression Inventory (BDI), and Beck Anxiety Inventory (BAI). Native thiol (NT) and total thiol (TT) levels were measured, SS levels and SS/NT ratio were calculated. Results. FMS patients demonstrated significantly lower NT levels, higher SS levels, and an elevated SS/NT ratio compared to the control group (p < 0.05 for all groups). In FMS patients, a statistically significant correlation was found between SS level and the SS/NT ratio, as well as the number of tender points (r=-0.24, p=0.02; r=-0.21, p=0.04), SF -36 pain subscales (r=0.22, p=0.032; r=0.21, p=0.04), and BAI scores (r=-0.22, p=0.01; r=-0.23 p=0.03). In the subgroup analysis, all health assessment scales were observed to exhibit statistically significant differences between the under -treatment group and newly -diagnosed group when compared to the control group (p < 0.05 for all groups). The FIQ, VAS, FSS, and BAI scores were found to be significantly lower in the under -treatment group as compared to the newly -diagnosed group (p < 0.05 for all groups). In the newly -diagnosed group, NT was significantly lower and the SS/NT ratio was significantly higher than those in the control group (p < 0.05). In the under -treatment group, SS levels and SS/NT ratio were significantly higher as compared to the control group (p < 0.05). In the multivariate regression analysis, which incorporated age, health assessment scales, patient subgroups, tender points, and duration of symptoms to predict the SS/NT ratio, variabes such as being in the under -treatment group, tender points, and BAI score were identified as significant predictors (p < 0.05). Conclusions. The thiol-SS balance was observed to shift in the oxidative direction, and oxidative stress was higher in the FMS group. The absence of a significant difference between the under -treatment group and the newly -diagnosed group in terms of thiol-SS balance parameters suggests a shift to oxidative stress in patients, independent of the treatment status.en_US
dc.identifier.doi10.21802/e-GMJ2024-A04
dc.identifier.issn2306-4285
dc.identifier.issn2414-1518
dc.identifier.issue1en_US
dc.identifier.urihttps://doi.org/10.21802/e-GMJ2024-A04
dc.identifier.urihttps://hdl.handle.net/20.500.12491/13532
dc.identifier.volume31en_US
dc.identifier.wosWOS:001201418100006en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.institutionauthorErel, Ozcan
dc.language.isoenen_US
dc.publisherIvano-Frankivsk Natl Medical Univen_US
dc.relation.ispartofGalician Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzYK_20240925en_US
dc.subjectDisulfideen_US
dc.subjectFibromyalgiaen_US
dc.subjectOxidative Stressen_US
dc.subjectPainen_US
dc.subjectThiolen_US
dc.titleThiol-Disulfide Balance in Fibromyalgia: A Case-Control Studyen_US
dc.typeArticleen_US

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