Predictive value of immature granulocyte count and other inflammatory parameters for disease severity in COVID?19 patients

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dc.authorscopusid55552330200
dc.authorscopusid58144436100
dc.authorscopusid57205103118
dc.authorscopusid58708312300
dc.authorscopusid6506993767
dc.authorscopusid15769086200
dc.contributor.authorAlisik, Murat
dc.contributor.authorErdogan, Utku Gorkem
dc.contributor.authorAtes, Merve
dc.contributor.authorSert, Mehmet Alp
dc.contributor.authorYis, Ozgur Mehmet
dc.contributor.authorBugdayci, Guler
dc.date.accessioned2024-09-25T19:45:09Z
dc.date.available2024-09-25T19:45:09Z
dc.date.issued2021
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractObjectives: This study was designed to compare the immature granulocyte (IG) count, IG-to-lymphocyte ratio (IGLR), complete blood count (CBC) values, and inflammatory parameters of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), C-reactive protein (CRP), ferritin level, and CRP-to-albumin ratio (CAR) measured at hospital admission in patients with coronavirus disease 2019 (COVID-19) and non-COVID-19 patients and to compare these parameters between subgroups according to disease severity. In addition, these parameters were evaluated for predictive value related to the severity of COVID?19. Methods: The data of adult patients admitted with a suspected COVID-19 infection confirmed with real-time polymerase chain reaction testing of nasal and pharyngeal swab specimens were included in this retrospective study. Out-patient COVID-19-positive patients were enrolled in the mild group, hospitalized patients were classified in the moderate group, and patients admitted to the intensive care unit were categorized in the severe group. Results: A total of 1213 COVID-19-positive patients and 1034 COVID-19-negative patients were included in the study. The IGLR, NLR, PLR, CRP, CAR, and ferritin levels were significantly higher, and the leukocyte, IG, neutrophil, lymphocyte, monocyte, basophil, and eosinophil levels were significantly lower in the COVID-19-positive group than the COVID-19-negative group (p<0.05 for all). The severe group had higher median IG, IGLR, neutrophil, NLR, PLR levels than the mild, moderate, and COVID-19-negative groups (p<0.05 for all). Receiver operating characteristic analysis revealed an area under the curve value for IGLR, CAR, CRP, IG, NLR, and ferritin of 0.868, 0.860, 0.834, 0.848, 0.845, 0.841, and 0.827, respectively, which differentiated severe COVID-19 patients from mild and moderate COVID-19 patients. Conclusion: The results suggest that the IGLR may be useful to distinguish severe COVID-19 patients at the time of admission. Further exploration is warranted to fully determine the potential value of the IGLR in disease monitoring. © 2021 by International Journal of Medical Biochemistryen_US
dc.identifier.doi10.14744/ijmb.2021.03164
dc.identifier.endpage149en_US
dc.identifier.issn2587-2362
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85135891278en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage143en_US
dc.identifier.trdizinid487354en_US
dc.identifier.urihttps://doi.org/10.14744/ijmb.2021.03164
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/487354
dc.identifier.urihttps://hdl.handle.net/20.500.12491/12887
dc.identifier.volume4en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherKare Publishingen_US
dc.relation.ispartofInternational Journal of Medical Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzYK_20240925en_US
dc.subjectcomplete blood counten_US
dc.subjectCOVID-19en_US
dc.subjectC?reactive proteinen_US
dc.subjectimmature granulocyteen_US
dc.subjectimmature granulocyte-to-lym-phocyte ratioen_US
dc.subjectinflammatory markersen_US
dc.titlePredictive value of immature granulocyte count and other inflammatory parameters for disease severity in COVID?19 patientsen_US
dc.typeArticleen_US

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