Kronik plak tip psoriazis hastalarının kardiyovasküler risk açısından değerlendirilmesi
Küçük Resim Yok
Tarih
2014
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Bolu Abant İzzet Baysal Üniversitesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Psoriazis immu?n aracılı, kronik, tekrarlayıcı inflamatuar bir dermatoztur. Birc?ok epidemiyolojik c?alısma, psoriazis hastalarının normal popu?lasyona go?re c?ok daha yu?ksek kardiyovasku?ler hastalık riskine sahip oldug?unu go?stermektedir. Etiyopatogenezde psoriazisteki kronik inflamasyonun ateroskleroz ve vasku?ler endotelyal hasar gelis?iminde etkin bir rolu? oldug?u du?s?u?nu?lmektedir. Bu nedenle son yapılan c?alıs?malarda, vasku?ler endotelyal hasar belirtec?lerinden olan endokan ve ateroskleroz gelis?iminde rolu? olan homosistein du?zeyleri incelenmektedir. Biz de geleneksel kardiyovasku?ler risk fakto?rlerinin es?lik etmedigi bireylerde, serum endokan, homosistein du?zeyleri ve ekokardiyografik parametreler ile psoriazis hastalarının kardiyovasku?ler risk ac?ısından incelenmesini amac?ladık. C?alıs?mamız, kronik plak tip psoriazis tanısı almıs? 40 hasta ve demografik ve biyokimyasal parametreler ac?ısından istatistiksel farklılık go?stermeyen 40 sag?lıklı kontrol grubu ile yapıldı. Psoriazis grubunda, serum endokan ve homosistein du?zeyinin, kontrol grubuna go?re istatistiksel olarak anlamlı derecede yu?ksek oldug?u saptandı. (p<0,001). Serum endokan du?zeyi ile hastalık su?resi pozitif korelasyon go?stermekteydi (p<0.001, r=0,725). Tei indeksinin, psoriazis grubunda, kontrol grubuna go?re anlamlı derecede yu?ksek oldug?u saptandı (p<0,001). E/A ve E/Em oranının ise hasta grubunda anlamlı derecede du?s?u?k oldug?u saptandı (p<0.001). Sol ventriku?l asenkronisini go?steren tu?m DSG parametrelerinin, psoriasis grubunda kontrol grubuna go?re istatistiksel olarak anlamlı derecede yu?ksek oldug?u tespit edildi (p<0.001). Sonuc? olarak, psoriazis grubunda serum endokan, homosistein yu?ksekligi ve kardiyak parametrelerin kontrol grubuna kıyasla anlamlı oranda farklılık go?stermesi, psoriaziste subklinik kardiyak hasarın olustug?u ve bunda psoriazis hastalıg?ının bas?lıbas?ına kardiyovasku?ler bir risk fakto?ru? oldug?u hipotezini desteklemektedir. Ancak bulgularımızın daha genis? c?alısmalarla desteklenmesi gerekmektedir. Anahtar Kelimeler: Psoriazis, Kardiyovasku?ler komorbidite, Endokan, Homosistein, Ekokardiyografi
Psoriasis is an immune mediated, chronic, recurrent, inflammatory dermatosis. Several epidemiologic studies have showed that psoriasis patients have higher risk of cardiovascular disease compared to healthy population In the etiopathogenesis of cardiac disorders, chronic inflammation of psoriasis plays an effective role in the development of atherosclerosis and vascular endothelial injury. Therefore, in recent studies, the levels of endocan, a marker of vascular injury and homocysteine, which has a role in the development of atherosclerosis, are being examined. We also aimed to investigate the correlation between serum endocan, homocysteine levels, echocardiographic parameters and cardiovascular risk in psoriasis patient without traditional cardiovascular risk factors. Our study was performed on 40 patients with chronic plaque type psoriasis and a group of 40 healthy volunteers who do not generate statistically significant differance about demographic and biochemical parameters. Serum endocan and homocysteine levels were significantly higher in patients compared to controls (p<0,001). There was a positive correlation between serum endocan levels and the duration of the disease (p<0.001, r=0,725). Tei index was significantly higher in patients compared to controls (p<0,001). E/A and E/Em ratios were lower in patients compared to controls (p=0,028). All TSI parameters related to left ventricular asynchrony were higher in patients significantly, compared to the control groups (p<0.001). In conclusion, higher serum levels of endocan and homocystein and the significant variation in cardiac parameters in psoriasis patients compared to controls support the hypothesis that subclinical cardiac damage occurs in psoriasis and psoriasis alone is a cardiovascular risk factor. More comprehensive studies are needed to support these results. Key Words: Psoriasis, cardiovascular comorbidities, endocan, homocysteine, echocardiography
Psoriasis is an immune mediated, chronic, recurrent, inflammatory dermatosis. Several epidemiologic studies have showed that psoriasis patients have higher risk of cardiovascular disease compared to healthy population In the etiopathogenesis of cardiac disorders, chronic inflammation of psoriasis plays an effective role in the development of atherosclerosis and vascular endothelial injury. Therefore, in recent studies, the levels of endocan, a marker of vascular injury and homocysteine, which has a role in the development of atherosclerosis, are being examined. We also aimed to investigate the correlation between serum endocan, homocysteine levels, echocardiographic parameters and cardiovascular risk in psoriasis patient without traditional cardiovascular risk factors. Our study was performed on 40 patients with chronic plaque type psoriasis and a group of 40 healthy volunteers who do not generate statistically significant differance about demographic and biochemical parameters. Serum endocan and homocysteine levels were significantly higher in patients compared to controls (p<0,001). There was a positive correlation between serum endocan levels and the duration of the disease (p<0.001, r=0,725). Tei index was significantly higher in patients compared to controls (p<0,001). E/A and E/Em ratios were lower in patients compared to controls (p=0,028). All TSI parameters related to left ventricular asynchrony were higher in patients significantly, compared to the control groups (p<0.001). In conclusion, higher serum levels of endocan and homocystein and the significant variation in cardiac parameters in psoriasis patients compared to controls support the hypothesis that subclinical cardiac damage occurs in psoriasis and psoriasis alone is a cardiovascular risk factor. More comprehensive studies are needed to support these results. Key Words: Psoriasis, cardiovascular comorbidities, endocan, homocysteine, echocardiography
Açıklama
Tıp Fakültesi, Deri ve Zührevi Hast. Ana Bilim Dalı
Anahtar Kelimeler
Dermatoloji, Dermatology
