The relationship between the level of serum uric acid and no-reflow phenomenon after primary percutaneous coronary intervention in patients with St segment elevated myocardial infarction
Küçük Resim Yok
Tarih
2010
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
No-reflow phenomenon is the absence of myocardial perfusion despite adequate dilatation of the infarct related coronary artery during percutaneous coronary intervention. Uric acid (UA) release during ischemia and washout from the ischemic zone during reperfusion is adenine nucleotide breakdown product. Therefore uric acid may play reperfusion injury and no-reflow. İn this study, we aimed to compare serum uric acid value of ST segment elevated Mİ patients groups whith no-reflow phenomenon and normal miyocardial perfusion after primary coronary intervention. 47 patients was enrolled consecutively to this study. During hospital admission, patients blood samples were taken for serum uric acid value. Patients was grouped as no reflow and normal perfusion groups according to myocardial blush grades (MBG). Patient with myocardial blush grades 0-1 were accepted as no-reflow group, patients with MBG 2-3 normal perfusion group. When the serum uric acid value of no-reflow and normal perfusion groups was compared, there was statistificaly significant difference (respectively 6,680±1,11 mg/dl versus 5,066±0,68 mg/dl. p<0,05). A significant correlation was found between the serum uric acid level and the presence of no-reflow phenomenon (r=0.598; p<0.025). Multivariate logistic regression analysis showed an independent relationship between no-reflow phenomenon and serum uric acid level (OR 1.815; 95% CI 1.098-1.493; p<0.031). In ST segment elevated Mİ patients with higher serum uric acid value before primary coronary intervention, no-reflow phenomenon is developed more frequently. Uric acid may play important role in mechanism of no-reflow phenomenon. © 2010 Düzce Medical Journal.
Açıklama
Anahtar Kelimeler
Acute myocardial infarction, No-reflow, Primary coronary intervention, Uric acid
Kaynak
Duzce Medical Journal
WoS Q Değeri
Scopus Q Değeri
Q4
Cilt
12
Sayı
3
