The effect of melatonin on tinnitus with respect to sleep and depression: A randomized clinical trial

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dc.authorscopusid56251292400
dc.authorscopusid27967502600
dc.authorscopusid37008364000
dc.authorscopusid15769882200
dc.authorscopusid6506758167
dc.authorscopusid36164167600
dc.authorscopusid18435340000
dc.contributor.authorKoybasi, Serap
dc.contributor.authorBoztas, M. Hamid
dc.contributor.authorBicer, Yusuf Ozgur
dc.contributor.authorSerin, Erdinc
dc.contributor.authorSuslu, Ahmet Emre
dc.contributor.authorFunda, Yasemin Ongun
dc.contributor.authorSereflican, Murat
dc.date.accessioned2024-09-25T19:44:12Z
dc.date.available2024-09-25T19:44:12Z
dc.date.issued2012
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractObjective: In this study we aimed to investigate the psychological status of tinnitus patients as well as the sleep quality and their relation to handicap caused by tinnitus using various scales. Additionally, serum melatonin levels and the effectiveness of melatonin treatment were studied. Study Design: Prospective, double blind, randomized controlled trial Materials and Methods: Patients were divided randomly into two groups as study (melatonin, n=13) and placebo (control, n=11) groups. Tinnitus Handicap Inventory (THI), Symptom Check List (SCL), Hospital Anxiety and Depression Scale (HAD), Beck Depression Inventory (BDI), Pittsburg Sleep Quality Index (PSQI) were applied. After filling the scales and giving the venous blood sample for melatonin measurements the patients were instructed to take one tablet (placebo or 3 mg melatonin) before sleep every night. After 8 weeks, second order scales were filled and melatonin measurements were repeated. Results: Serum melatonin levels were between 1-260 pg/ml; the mean was 38,7 pg/ml. The correlation of melatonin levels with THI and tinnitus duration was not significant. THI was found to correlate with different measures of the PSQI, HAD, and BDI in both groups. Statistical analysis failed to show any significant difference within and between groups in respect of anxiety, depressive symptoms and sleep as well as melatonin and handicap levels. When the groups were assessed according to the THI severity (mild/moderate to severe;THI 2); in the control group there was significant differences in PSQI 1 and PSQI 1 (p=0.0008, p=0.18), HAD 1, HAD 2 (0.002, 0.03), HAD Depression 1-2 (0.0, 0.006) BDI (p=0.007) PSQI 2 sleep disturbance (p=0.018) parameters. However, in the melatonin group it was found that there were significant differences in SCL 2 sleep latency, PSQI 2 sleep duration and total PSQI 2 parameters. (p=0.022, 0.027, 0.006 respectively)Conclusion: Patients with higher handicap may benefit melatonin in respect of sleep latency and duration as well as sleep quality comparing with the patients taking placebo. Moreover, melatonin efficiency may be related to its antidepressive effect. © 2005 The Mediterranean Society of Otology and Audiology.en_US
dc.identifier.endpage208en_US
dc.identifier.issn1308-7649
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-84864761968en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage201en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/12710
dc.identifier.volume8en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofJournal of International Advanced Otologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzYK_20240925en_US
dc.titleThe effect of melatonin on tinnitus with respect to sleep and depression: A randomized clinical trialen_US
dc.typeArticleen_US

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