Akut miyokard infarktüsü sonrası erken dönemdeki solunum fonksiyon testlerindeki değişiklikler
Küçük Resim Yok
Tarih
2003
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Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Bu çalışmada Akut Miyokard İnfarktüsü (AMI) sonrası erken dönemde (3-12.gün) solunum fonksiyon testlerindeki değişiklikler araştırılmıştır. Gereç ve Yöntem: Çalışmaya AMI'li 84 hasta (E/K: 70/14, yaş: 58±13) ve 81 sağlıklı birey (E/K: 62/19, yaş: 57±12) alındı. Spirometri ile solunum fonksiyon testi (SFT) yapılarak ZVK (zorlu vital kapasite), ZEV 1 (1 .saniyedeki zorlu ekspirasyon volümü), ZEV1/ZVK oranı ve ZEAH%25-75 (zorlu ekspirasyon ortası akım hızı) elde edildi (yaş ve cinse göre beklenen değerlerin %'si olarak). Bulgular: AMI grubunda kontrollere göre ZVK ve ZEV1 anlamlı olarak azalmıştı (ZVK; 75$\pm$24 ve 91$\pm$21, p<0.001, ZEV1; 81±29 ve 98±27, p<0.001). Fakat ZEV1/ZVK ve ZEAH%25-75 değerleri iki grupta benzerdi (p>0.05). AMI hastalar fizik muayenede inspiratuar raileri olan ve olmayanlar olarak iki gruba ayrıldığında, rali olanlarda FEV1 and FEV%25-75 anlamlı olarak düşüktü (FVC: 68$\pm$26 ve 80±21, p<0.03, FEV1:70±29 ve 89±25, p<0.04, FEF%25-75:75±46 ve 112$\pm$49, p<0.01). AMI lokalizasyonuna göre SFT sonuçları non-Q>inferior>anteroseptal>anterior olarak gittikçe azalan şekilde sıralandı. Fakat aradaki fark anlamlı değildi (p>0.05). Sonuç: FEV1/FVC ve FEF%25-75de azalma olmayıp FVC ve FEV1 de azalma olması AMI'li hastalarda solunum fonksiyonlarında restriktif tipte değişiklikler olduğunu göstermektedir. Ayrıca, buna sol kalp yetmezliğinin belirginleşmesiyle (staz rali varlığına göre) küçük hava yollarında obstruktif bir bozukluğunda (ZEAH o/o25.75 daki azalma) eklendiği söylenebilir.
Aim: in this study, we investigated changes in pulmonary function test (PFT) parameters in early stage of post AMI period (3-12 days). Material and Methods: 84 patients with AMI (M/F:70/14, age:58±13) and 81 healthy subjects (M/F:62/19, age:57+12) were recruited for the study. We measured forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), FEV1/FVC and forced expiratory flow betvveen 25 and 75 %(FEF25-75%) by performing PFT with spirometry (as % of expected age and gender adjusted values). Results: FVC and FEV1 were significantly less in AMI group than in controls subjects (FVC:75±24 vs 91$\pm$21, p<0.001, FEV1: 81$\pm$29 vs 98±27, p<0.001). But FEV1/FVC and FEF25-75% were similar in two groups p>0.05). When we divide AMI patients into two group with (n=37) and without (n=47) inspiratory crackles, FVC, FEV1 and FEV 25-75% were significantly less in the group with crackles (FVC:68+26 vs 80±21, p<0.03, FEV1:70±29 vs 89±25, p<0.04, FEF25-75%:75±46 vs 112±49, p<0.01). According to location of AMI, PFT results were in decreasing order, but difference was not statistically significant (p>0.05). Conclüsion: Decrease in FVC and FEV1 but not in FEV1/FVC and FEF 25-75% in AMI patients indicatş that AMI causes restrictive changes in respiratory function. Moreover, as signs of LV failure become evident (according topresence ör absence of inspiratory crackles), it can say that an obstructive pattern in small airvvays accompanies the situation.
Aim: in this study, we investigated changes in pulmonary function test (PFT) parameters in early stage of post AMI period (3-12 days). Material and Methods: 84 patients with AMI (M/F:70/14, age:58±13) and 81 healthy subjects (M/F:62/19, age:57+12) were recruited for the study. We measured forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), FEV1/FVC and forced expiratory flow betvveen 25 and 75 %(FEF25-75%) by performing PFT with spirometry (as % of expected age and gender adjusted values). Results: FVC and FEV1 were significantly less in AMI group than in controls subjects (FVC:75±24 vs 91$\pm$21, p<0.001, FEV1: 81$\pm$29 vs 98±27, p<0.001). But FEV1/FVC and FEF25-75% were similar in two groups p>0.05). When we divide AMI patients into two group with (n=37) and without (n=47) inspiratory crackles, FVC, FEV1 and FEV 25-75% were significantly less in the group with crackles (FVC:68+26 vs 80±21, p<0.03, FEV1:70±29 vs 89±25, p<0.04, FEF25-75%:75±46 vs 112±49, p<0.01). According to location of AMI, PFT results were in decreasing order, but difference was not statistically significant (p>0.05). Conclüsion: Decrease in FVC and FEV1 but not in FEV1/FVC and FEF 25-75% in AMI patients indicatş that AMI causes restrictive changes in respiratory function. Moreover, as signs of LV failure become evident (according topresence ör absence of inspiratory crackles), it can say that an obstructive pattern in small airvvays accompanies the situation.
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10
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3
