The Effects of Acute and Chronic Metformin Treatment on Penicillin Induced Epileptiform Activity in Rats

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dc.authoridSoyturk, Hayriye/0000-0002-0000-3768
dc.contributor.authorKilic, Umit
dc.contributor.authorDemir, Serif
dc.contributor.authorBeyazcicek, Ersin
dc.contributor.authorBeyazcicek, Ozge
dc.contributor.authorSoyturk, Hayriye
dc.date.accessioned2024-09-25T19:56:21Z
dc.date.available2024-09-25T19:56:21Z
dc.date.issued2022
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractObjective: The aim of this study is to investigate acute and chronic administered metformin on epileptiform activity induced by penicillin and antioxidant activity in rats. Methods: Eighty-four adult male Wistar albino rats were used in this study. The rats were divided into two large groups as acute and chronic groups, and later on each group was divided into different subgroups as control, sham, penicillin, metformin 100 mg/kg (Met_100), 200 mg/kg (Met_200) and only metformin 200 mg/kg (OMet_200) intraperitoneally. The substances were applied to the chronic groups for 21 days, while acute groups received them just before the initiation of epileptiform activity. In the present study, onset of first epileptiform activity, spike wave frequency and amplitude, and superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) parameters were evaluated. Results: No epileptiform activity was observed in the control, sham, and OMet_200 groups. When metformin doses of 100 mg/kg, 200 mg/kg were compared with the penicillin group in both acute and chronic groups, the onset of first epileptiform activity was prolonged, spike wave frequency and spike wave amplitude decreased significantly. SOD, CAT and GPx levels were found to be significantly different in the acute and chronic metformin groups compared to the penicillin group. Conclusion: In conclusion, this study shows that metformin can decrease epileptic seizures and increase the level of antioxidant enzymes and it can be used in the treatment of epilepsy in the future.en_US
dc.description.sponsorshipDuzce University Scientific Research Coordination Office [2019.04.01.1022]en_US
dc.description.sponsorshipThis research was supported as financial by Duzce University Scientific Research Coordination Office (Project number: 2019.04.01.1022).en_US
dc.identifier.doi10.4274/jarem.galenos.2022.25238
dc.identifier.endpage98en_US
dc.identifier.issn2146-6505
dc.identifier.issn2147-1894
dc.identifier.issue2en_US
dc.identifier.startpage87en_US
dc.identifier.trdizinid1128396en_US
dc.identifier.urihttps://doi.org/10.4274/jarem.galenos.2022.25238
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1128396
dc.identifier.urihttps://hdl.handle.net/20.500.12491/13246
dc.identifier.volume12en_US
dc.identifier.wosWOS:001129954000008en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherGalenos Publ Houseen_US
dc.relation.ispartofJournal of Academic Research in Medicine-Jaremen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzYK_20240925en_US
dc.subjectAntioxidanten_US
dc.subjectelectrocorticographyen_US
dc.subjectepilepsyen_US
dc.subjectepileptiform activityen_US
dc.subjectmetforminen_US
dc.titleThe Effects of Acute and Chronic Metformin Treatment on Penicillin Induced Epileptiform Activity in Ratsen_US
dc.typeArticleen_US

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