Mild Renal Dysfunction Among Turkish Adults: Prevalence and Its Association With Insulin Resistance

Basit Öğe Kaydı
dc.authoriduyarel, huseyin/0000-0001-9931-5456
dc.contributor.authorOnat, Altan
dc.contributor.authorYazici, Mehmet
dc.contributor.authorHergenc, Gulay
dc.contributor.authorUyarel, Huseyin
dc.contributor.authorEsen, A. Metin
dc.contributor.authorKarabulut, Ahmet
dc.contributor.authorCan, Gunay
dc.date.accessioned2024-09-25T19:57:40Z
dc.date.available2024-09-25T19:57:40Z
dc.date.issued2006
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractObjectives: To investigate the prevalence of mild renal dysfunction and its association with insulin resistance (IR), metabolic syndrome (MS) or its components among Turkish adults. Methods: Serum creatinine concentrations were measured in 1048 male and female subjects. After excluding cases with diabetes mellitus, 933 participants of a representative cohort were studied cross-sectionally. Glomerular filtration rate (GFR) was estimated based on serum creatinine concentrations using the Modification of Diet in Renal Disease formula. GFR was divided into 3 categories constituting chronic kidney disease stages 2 and 3 3. MS was identified by modified criteria of the Adult Treatment Panel-III. Results: MS existed in 38.7% of the cohort. Mild renal dysfunction (estimated GFR 60 to 89.9 mL/min/1.73 m(2)) existed in 50% of the study sample in both genders. Compared to the group with normal GFR, in category II, age-adjusted estimates of body mass index, homeostatic model assessment (HOMA) index, blood pressures, total, HDL-, LDL-cholesterol and serum proteins were all significantly elevated in both genders, as were apo B and log TSH in women alone. Stated variables were also significantly and inversely correlated with GFR. Whereas MS was not significantly associated with GFR categories, nor with reduced GFR when controlled for HOMA, HOMA D adjusted for MS as well as for sex, age and systolic BP-was significantly associated with likelihood for reduced GFR. Conclusions: Mild impairment of kidney function is very common in nondiabetic middle-aged and elderly adults, is associated mainly with IR and related cardiovascular risk factors, in the absence of MS-related atherogenic dyslipidemia. IR is important even in mild reduction in GFR, an action independent of central obesity-related components of MS.en_US
dc.identifier.endpage206en_US
dc.identifier.issn1300-7718
dc.identifier.issue4en_US
dc.identifier.startpage197en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/13546
dc.identifier.volume15en_US
dc.identifier.wosWOS:000217142900005en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isotren_US
dc.publisherTurk Nefroloji Diyaliz Transplantasyon Dergisien_US
dc.relation.ispartofTurkish Nephrology Dialysis And Transplantation Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzYK_20240925en_US
dc.subjectdyslipidemiaen_US
dc.subjectglomerular filtration rateen_US
dc.subjectkidney dysfunctionen_US
dc.subjectinsulin resistanceen_US
dc.subjectmetabolic syndromeen_US
dc.subjectpopulation-based studyen_US
dc.titleMild Renal Dysfunction Among Turkish Adults: Prevalence and Its Association With Insulin Resistanceen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu