Comparison of age-related anti müllerian hormone, inhibin-b levels and follicle reserve in rat ovarium

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dc.authorscopusid57103830300
dc.authorscopusid15769086200
dc.authorscopusid35356400800
dc.contributor.authorSöyler, Gizem
dc.contributor.authorBugdayci, Güler
dc.contributor.authorKükner, Aysel
dc.date.accessioned2024-09-25T19:43:05Z
dc.date.available2024-09-25T19:43:05Z
dc.date.issued2021
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractAnti-Müllerian hormone (AMH) and Inhibin B (INHB) in the glycoprotein structure are members of the transforming growth factor ? family and expressed by granulosa cells from puberty. AMH is a factor that increases the life span of small developing follicles. For this reason, it is widely used to determine the ovarian reserve and age. Inhibin-B secreted from granulosa cells plays a role in regulation of the Follicle Stimulating Factor (FSH) and determination of the follicle diameter. There are few studies on the effect of these two age-related hormones on ovarian histology in rats. In this study, AMH and INHB expression in ovarian tissues of female rats of different age groups, their relationship with ovarian structure and folliculogenesis were examined histologically and biochemically. Wistar Albino rats were used in the study and a total of 3 groups were formed. The ovaries of rats in the pre-oestrous period were collected, and follicle count was performed on tissue sections in batches. Expression of AMH in the follicles was identified immunohistochemically. In serum, AMH and INHB levels were assessed by ELISA method and their significance was evaluated statistically. Results from light microscopic examination determined that AMH was expressed from the granulosa cells of developing follicles. INHB expression during the prepubertal period and AMH had a protective effect on the ovarian reserve and the number of developing follicles, respectively. © 2021, Universidad de la Frontera. All rights reserved.en_US
dc.description.sponsorshipAbant Izzet Baysal University Scientific Research Projects Unit, (2016.08.03.1080)en_US
dc.identifier.doi10.4067/S0717-95022021000401074
dc.identifier.endpage1080en_US
dc.identifier.issn0717-9367
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85113744934en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1074en_US
dc.identifier.urihttps://doi.org/10.4067/S0717-95022021000401074
dc.identifier.urihttps://hdl.handle.net/20.500.12491/12421
dc.identifier.volume39en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherUniversidad de la Fronteraen_US
dc.relation.ispartofInternational Journal of Morphologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzYK_20240925en_US
dc.subjectAgeen_US
dc.subjectAnti-Müllerian hormoneen_US
dc.subjectInhibin Ben_US
dc.subjectOvaryen_US
dc.subjectRaten_US
dc.titleComparison of age-related anti müllerian hormone, inhibin-b levels and follicle reserve in rat ovariumen_US
dc.title.alternativeComparación de la hormona anti-mülleriana relacionada con la edad, los niveles de inhibina-b y la reserva folicular en el ovario de rata]en_US
dc.typeArticleen_US

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