Role of neutrophil activation in post-operative adhesion formation in a rat model

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dc.authoridAlatas, Erkan/0000-0001-6423-5106
dc.contributor.authorAlatas, E
dc.contributor.authorAlatas, Ö
dc.contributor.authorUslu, S
dc.contributor.authorÇolak, Ö
dc.contributor.authorGünal, Ö
dc.date.accessioned2024-09-25T19:56:10Z
dc.date.available2024-09-25T19:56:10Z
dc.date.issued1999
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractThe aim of this study was to evaluate the role of neutrophil activation during adhesion formation in rat peritoneal adhesion model. A 1 X 1 cm area of peritoneum and transversus abdominal muscle was removed on the right lower abdominal wall of 4 rats. 14 days later, the animals underwent a second laparotomy. After the adhesion formations were evaluated, adhesion bands adhered to the peritoneal defect were excised, together with normal tissue 1 cm from the adhesion band. Myeloperoxidase and elastase activities were determined in peritoneal tissue samples excised during the first laparotomy (control group), adhesion bands adhered to the peritoneal defect (adhesion group) and peritoneal tissue excised during the second laparotomy 1 cm from the peritoneal defect (normal peritoneum group). Myeloperoxidase activity was significantly higher in the adhesion group that in both the control and normal peritoneum group (P < 0.001). Elastase activity in the adhesion group was significantly higher than in the control group (P < 0.001). The normal peritoneum group elastase activity was significantly higher than in the control group (P < 0.001), but significantly lower than in the adhesion group (P < 0.001). The increased activities of neutrophil activation markers in normal peritoneum tissues may suggest that the inflammatory reaction was not limited to the adhered peritoneum. The role of elastase inhibitors in preventing peritoneal adhesion should be determined in further studies. Med Sci Res 27:631-633 (C) 1999 Lippincott Williams & Wilkins.en_US
dc.identifier.endpage633en_US
dc.identifier.issn0269-8951
dc.identifier.issue9en_US
dc.identifier.startpage631en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/13163
dc.identifier.volume27en_US
dc.identifier.wosWOS:000082633400018en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofMedical Science Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzYK_20240925en_US
dc.subjectadhesionen_US
dc.subjectelastaseen_US
dc.subjectmyeloperoxidaseen_US
dc.subjectneutrophil activationen_US
dc.subjectperitoneumen_US
dc.titleRole of neutrophil activation in post-operative adhesion formation in a rat modelen_US
dc.typeArticleen_US

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