Histopathologic changes in the rabbit submandibular gland after 5-fluorouracil chemotherapy

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dc.authoridyilmaz, mustafa deniz/0000-0002-7437-0229
dc.authoridKenar, Tuna/0000-0003-1182-6505
dc.contributor.authorOzel, Oktay
dc.contributor.authorAycicek, Abdullah
dc.contributor.authorKenar, Fethullah
dc.contributor.authorAktepe, Fatma
dc.contributor.authorSargin, Ramazan
dc.contributor.authorYilmaz, Mustafa Deniz
dc.contributor.authorDerekoy, Fevzi Sefa
dc.date.accessioned2024-09-25T19:56:08Z
dc.date.available2024-09-25T19:56:08Z
dc.date.issued2010
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractAim: To determine the early-stage effects of 5-fluorouracil (5-FU) on the histology of the submandibular gland. Materials and methods: The study included 30 New Zealand rabbits. They were divided into 3 groups. No drugs were administered to group 1 (control group), and 5-FU was administered for 5 days to group 2 and for 10 days to group 3. Submandibular gland excision was then performed. Histopathological examination was performed with hematoxylin-eosin staining, apoptosis was determined based on TUNEL staining, and cell proliferation was examined using the PCNA antibody. Results: While no granular change was seen in group 1, granular change was observed in the acinar cell cytoplasm in 5 rabbits in group 2 and in 5 rabbits in group 3 (P < 0.05). The rate of apoptosis in the acinar and ductal cells was higher in group 3 than in groups 1 and 2, according to TUNEL staining (P < 0.05). While no cellular proliferation in the acinar cells was observed with PCNA staining in any of the groups, there was a statistically significant difference in group 3 in ductal cellular proliferation, as compared to groups 1 and 2 (P < 0.05). Conclusion: Toxic effects of 5-FU were observed after 10 days. We suggest that a standard animal model can be developed based on group 3 results. We also think that drug trials concerned with protecting the salivary gland from the effects of chemotherapy can be conducted based on this model.en_US
dc.identifier.doi10.3906/sag-0807-10
dc.identifier.endpage220en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue2en_US
dc.identifier.startpage213en_US
dc.identifier.urihttps://doi.org/10.3906/sag-0807-10
dc.identifier.urihttps://hdl.handle.net/20.500.12491/13127
dc.identifier.volume40en_US
dc.identifier.wosWOS:000278446800008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technological Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzYK_20240925en_US
dc.subject5-Fluorouracilen_US
dc.subjectmucositisen_US
dc.subjectapoptosisen_US
dc.subjectchemotherapyen_US
dc.titleHistopathologic changes in the rabbit submandibular gland after 5-fluorouracil chemotherapyen_US
dc.typeArticleen_US

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