Kronik viral hepatit nedeniyle interferon tedavisi alan hastaların yan etkilerle baş etme yöntemleri, yaşadıkları güçlükler ve yaşam kaliteleri
Küçük Resim Yok
Tarih
2004
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Bolu Abant İzzet Baysal Üniversitesi
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
ÖZET KRONİK VİRAL HEPATİT NEDENİYLE İNTERFERON TEDAVİSİ ALAN HASTALARIN YAN ETKİLERLE BAŞ ETME YÖNTEMLERİ, YAŞADIKLARI GÜÇLÜKLER VE YAŞAM KALİTELERİ Bostancı Hümeyra Yüksek Lisans, Hemşirelik Bölümü Tez Danışmanı: Doç. Dr. Feray Gökdoğan Şubat 2004, 115 sayfa Araştırma, kronik viral hepatit nedeniyle interferon tedavisi alan hastaların yan etkilerle baş etme yöntemleri, yaşadıkları güçlükler ve yaşam kalitelerinin belirlenmesi amacıyla prospektif kohort tipi araştırma tekniği ile yapılmıştır. Bu araştırma, Hacettepe Üniversitesi Tıp Fakültesi Hastanesi Gastroenteroloji Polikliniği ve Ankara Üniversitesi Tıp Fakültesi Gastroenteroloji Kliniği Karaciğer Hastalıkları İzleme polikliniklerinde gerçekleştirilmiştir. Araştırmanın örneklemi 15 Kasım 2002 ve 15 Mayıs 2003 tarihleri arasında bu sağlık kurumlarına başvuran toplam 43 hasta oluşturmuştur. Hastalar, tedavilerinin ilk üç ayı süresince ilk bir ay haftalık olarak, daha sonra iki haftalık aralarla ifade ettikleri yan etkilere bağlı özellikler ve başetme yöntemleri açısından izlenmiştir.Verilerin toplanmasında hasta tanıtım formu, tedavi öncesi bilgi formu, interferon tedavisi izlem formu, tedaviye bağlı yaşanan güçlüklere yönelik soru formu ve EORTC QOL-30 Yaşam Kalitesi Ölçeği kullanılmıştır. Veriler, tanımlayıcı istatistiklerden yüzdelik, ortalama, standart sapma ve önemlilik testlerinden ki-kare, ANOVA testi, Cochran's Q testi kullanılarak analiz edilmiştir. Tedavi süresince en sık görülen ateş, üşüme, titreme (p<0.05), baş ağrısı, bulantı-kusma, iğne yerinde ağrı/hassasiyet (p<0.05), kas ağrısı/eklem ağrısı ve vücutta döküntü gibi yan etkilerin sıklığı ve şiddetinin genellikle birinci hafta yüksek, 4. ve 12. haftalar arasında düşük; huzursuzluk, saç dökülmesi (p<0.05), yorgunluk ve dikkati toplama güçlüğü gibi yan etkilerin sıklığı ve şiddetinin ise birinci haftada düşük, 4. ve 12. haftaya haftalarda yüksek olarak saptanmıştır. Hastaların bu yan etkilerle baş etmede çoğunlukla parasetamol aldıkları belirlenmiştir, interferon tedavisi boyunca hastaların %74.4'ü güçlük yaşadığını ifade etmiştir. Bu güçlükler, çoğunlukla psikiyatrik yan etkiler (%31.3) ve yorgunluktur (%29.2). Hastaların genel sağlık durumu ve yaşam kalitesi puan ortalamalarının (55.6±21.9) tedavinin 1. ay (37.2±22.7) ve 3. ayında (39.1Ü9.7) düştüğü belirlenmiştir (p<0.05). Tedavi öncesi fiziksel, rol, duygusal, bilişsel ve sosyal fonksiyonlardaki iyilik durumunun tedavinin 1. ve 3. ayma doğru azaldığı görülmektedir (p<0.05). Yorgunluk, bulantı-kusma, ağrı, solunum güçlüğü, uyuma güçlüğü ve iştah kaybının tedavinin 1. ve 3. ayında arttığı ve yaşam kalitesini olumsuz etkilediği saptanmıştır (p<0.05). Anahtar kelimeler: Kronik viral hepatit, interferon tedavisi, yan etkiler, yaşam kalitesi, baş etme. vı
ABSTRACT DIFFICULTIES ENCOUNTERED, COPING WITH SIDE EFFECTS AND QUALITY OF LIFE OF PATIENTS RECEIVING INTERFERON THERAPY FOR CHRONIC HEPATITIS Bostancı, Hümeyra M. Sc, Department of Nursing Supervision Assoc. Prof. Dr. Feray Gökdoğan February, 2004, 115 pages Aim of the study was to identify difficulties encountered, coping with side effects and quality of life of patients receiving interferon therapy for chronic hepatitis. It was planned as a prospective cohort type study. This study was conducted in the Hacettepe University Department of Gastroenterology and Ankara University Department of Gastroenterology and Hepatology Institute. Study sample was total of 43 patients who were admitted between November 15th 2002 and May 15th 2003. During the first three months of treatment, patients were followed-up weekly for the first month, then biweekly intervals, for treatment related side effects which were stated and coping methods. For data collections demographic questionnaire, pretreatment knowledge form, interferon treatment related side effects follow-up forms and EORTC-QLQ inC30 were used. Data were analyzed by using descriptive statistics as percentiles, means, standard deviation and tests of importance as ANOVA, chi-square and Cochran's Q. It was noted that; side effects such as fever, rigors (p<0.05), headache, nausea and vomiting, pain at injection site (p<0.05), muscle and joint pains and rash were most prevalent and severe at first week and subsided during the course of treatment, whereas prevalence and severity of irritability, hair loss (p<0.05), fatigue and difficulties in concentration has increased through the treatment course. Patients mostly used paracetamol for coping the side effects. During the interferon treatment %74.4 patients had some difficulties, which were mostly psychiatric side effects (%31.3) and fatigue (%29.2). Mean scores of quality of life and global health status of patients (55. 6 ± 21.9) has decreased at the first (37.2 ± 22.7) and third month (39.1 ± 19.7) of the treatment (p<0.05). Pretreatment well being of physical, role, emotional, cognitive and social functions have also declined at first and 3rd month of treatment (p<0.05). Symptoms like, fatigue, nausea and vomiting, pain, dyspnea, insomnia, loss of appetite have increased at the first and 3rd month of treatment, which in turn, affected quality of life in negative ways (p<0.05). Key words: Chronic viral hepatitis, interferon treatment, side effects, quality of life, coping with. IV
ABSTRACT DIFFICULTIES ENCOUNTERED, COPING WITH SIDE EFFECTS AND QUALITY OF LIFE OF PATIENTS RECEIVING INTERFERON THERAPY FOR CHRONIC HEPATITIS Bostancı, Hümeyra M. Sc, Department of Nursing Supervision Assoc. Prof. Dr. Feray Gökdoğan February, 2004, 115 pages Aim of the study was to identify difficulties encountered, coping with side effects and quality of life of patients receiving interferon therapy for chronic hepatitis. It was planned as a prospective cohort type study. This study was conducted in the Hacettepe University Department of Gastroenterology and Ankara University Department of Gastroenterology and Hepatology Institute. Study sample was total of 43 patients who were admitted between November 15th 2002 and May 15th 2003. During the first three months of treatment, patients were followed-up weekly for the first month, then biweekly intervals, for treatment related side effects which were stated and coping methods. For data collections demographic questionnaire, pretreatment knowledge form, interferon treatment related side effects follow-up forms and EORTC-QLQ inC30 were used. Data were analyzed by using descriptive statistics as percentiles, means, standard deviation and tests of importance as ANOVA, chi-square and Cochran's Q. It was noted that; side effects such as fever, rigors (p<0.05), headache, nausea and vomiting, pain at injection site (p<0.05), muscle and joint pains and rash were most prevalent and severe at first week and subsided during the course of treatment, whereas prevalence and severity of irritability, hair loss (p<0.05), fatigue and difficulties in concentration has increased through the treatment course. Patients mostly used paracetamol for coping the side effects. During the interferon treatment %74.4 patients had some difficulties, which were mostly psychiatric side effects (%31.3) and fatigue (%29.2). Mean scores of quality of life and global health status of patients (55. 6 ± 21.9) has decreased at the first (37.2 ± 22.7) and third month (39.1 ± 19.7) of the treatment (p<0.05). Pretreatment well being of physical, role, emotional, cognitive and social functions have also declined at first and 3rd month of treatment (p<0.05). Symptoms like, fatigue, nausea and vomiting, pain, dyspnea, insomnia, loss of appetite have increased at the first and 3rd month of treatment, which in turn, affected quality of life in negative ways (p<0.05). Key words: Chronic viral hepatitis, interferon treatment, side effects, quality of life, coping with. IV
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Sağlık Bilimleri Enstitüsü, Hemşirelik Ana Bilim Dalı
Sağlık Bilimleri Enstitüsü, Hemşirelik Ana Bilim Dalı
Anahtar Kelimeler
Hemşirelik, Nursing
