Effects of adipose tissue-derived stromal vascular fraction on osteochondral defects treated by hyaluronic acid-based scaffold: An experimental study

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dc.contributor.authorŞahin, Abdullah Alper
dc.contributor.authorDeğirmenci, Erdem
dc.contributor.authorÖzturan, Kutay Engin
dc.contributor.authorFirat, Tülin
dc.contributor.authorKükner, Aysel
dc.date.accessioned2024-09-25T20:23:36Z
dc.date.available2024-09-25T20:23:36Z
dc.date.issued2021
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractObjectives: This study aims to evaluate the effect ofadipose-derived stromal vascular fraction (SVF) onosteochondral defects treated by hyaluronic acid (HA)-basedscaffold in a rabbit model.Materials and methods: Eighteen white New Zealand rabbitswere randomly grouped into the experimental group (n=9) andcontrol group (n=9). In all groups, osteochondral defects wereinduced on the weight-bearing surfaces of the right femoralmedial condyles, and a HA-based scaffold was applied to thedefect area with microfractures (MFs). In this study, 1 mLof adipose-derived SVF was injected into the knee joints ofthe rabbits in the experimental group. For histological andmacroscopic evaluation, four rabbits were randomly selectedfrom each group at Week 4, and the remaining rabbits weresacrificed at the end of Week 8. Macroscopic assessments of allsamples were performed based on the Brittberg scoring system,and microscopic evaluations were performed based on theO’Driscoll scores.Results: Samples were taken at Weeks 4 and 8. At Week 4,the O’Driscoll scores were significantly higher in the controlgroup than the experimental group (p=0.038), while there wasno significant difference in the Brittberg scores between the twogroups (p=0.108). At Week 8, the O’Driscoll score and Brittbergscores were statistically higher in the experimental groupthan in the control group (p=0.008 and p=0.007, respectively).According to the microscopic evaluation, at the end of Week 8,the cartilage thickness was greater in the experimental group,and nearly all of the defect area was filled with hyaline cartilage.Conclusion: Application of adipose-derived SVF withMF-HA-based scaffold was better than MF-HA-based scaffoldtreatment in improving osteochondral regeneration. Therefore,it can be used in combination with microfracture and scaffold toaccelerate cartilage regeneration, particularly in the treatment ofsecondary osteoarthritis.en_US
dc.identifier.doi10.52312/jdrs.2021.19
dc.identifier.endpage354en_US
dc.identifier.issn2687-4784
dc.identifier.issn2687-4792
dc.identifier.issue2en_US
dc.identifier.startpage347en_US
dc.identifier.trdizinid451172en_US
dc.identifier.urihttps://doi.org/10.52312/jdrs.2021.19
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/451172
dc.identifier.urihttps://hdl.handle.net/20.500.12491/15987
dc.identifier.volume32en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofJoint diseases and related surgeryen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzYK_20240925en_US
dc.titleEffects of adipose tissue-derived stromal vascular fraction on osteochondral defects treated by hyaluronic acid-based scaffold: An experimental studyen_US
dc.typeArticleen_US

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