The impact of dexmedetomidine vs midazolam on coagulation factors during nasal surgery

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dc.authorscopusid15073106000
dc.authorscopusid15848312900
dc.authorscopusid20136555600
dc.authorscopusid15769882200
dc.authorscopusid11738942300
dc.authorscopusid55898697800
dc.contributor.authorKaraaslan, Kazim
dc.contributor.authorGülcü, Nebahat
dc.contributor.authorYilmaz, Fahrettin
dc.contributor.authorSerin, Erdinç
dc.contributor.authorÇolak, Cemil
dc.contributor.authorKoço?lu, Hasan
dc.date.accessioned2024-09-25T19:44:21Z
dc.date.available2024-09-25T19:44:21Z
dc.date.issued2008
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractObjective: Dexmedetomidine is an ?2 adrenergic receptor agonist and has sedative analgesic properties. We aimed to investigate the effects of dexmedetomidine coagulation system in monitored anesthesia care (MAC) patients, and to compare it with that of midazolam. Material and Methods: Sixty patients undergoing nasal surgery with local anesthesia were recruited. In Group D, dexmedetomidine was infused iv 1 ?g kg-1 over 10 min followed by 0.5 ?g kg-1 h-1. In Group M, midazolam was given iv 40 ?g kg-1 followed by 50 ?g kg-1 h-1. The effects of both drugs on coagulation system were evaluated by means of hemoglobin (Hb), hematocrit (Hte), platelet count, fibrinogen, protrombin time, active partial tromboplastine time (aPTT), INR, protein C, protein S and antitromhin III (ATIII) parameters with preoperatively (t0), early (t1) and 6 hours after postoperatively (t2). Results: Postoperative early (t1) and late (t2) Hb, Hte, aPTT and ATIII were decreased in both groups, and fibrinogen were decreased on these times in group M compared with preoperative values (p<0.05). Fibrinogen values were lower in t1 and t2 measurement in group M compared with group D (p<0.05). Conclusion: We conclude that the uses of dexmedetomidine or midazolam in MAC for nasal surgery do not have any effect on coagulation parameters.en_US
dc.identifier.endpage37en_US
dc.identifier.issn1888-4415
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-67650422084en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage31en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/12789
dc.identifier.volume52en_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.relation.ispartofRevista Espanola de Cirugia Ortopedica y Traumatologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzYK_20240925en_US
dc.subjectCoagulationen_US
dc.subjectDexmedetomidineen_US
dc.subjectMidazolamen_US
dc.titleThe impact of dexmedetomidine vs midazolam on coagulation factors during nasal surgeryen_US
dc.title.alternativeNazal cerrahi olgularinda deksmedetomidin ve midazolam kullaniminin koagülasyon üzerine etkileri]en_US
dc.typeArticleen_US

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