Preparation and In vivo evaluation of gelatine implants containing EGF-PLGA microspheres in tendon healing

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dc.authorscopusid6603247087
dc.authorscopusid14025387100
dc.authorscopusid57193742036
dc.authorscopusid7005719289
dc.authorscopusid6701523442
dc.authorscopusid6506917806
dc.authorscopusid56251101600
dc.contributor.authorOrhan, Zafer
dc.contributor.authorCevher, Erdal
dc.contributor.authorGül, Mine Orlu
dc.contributor.authorAlper, Murat
dc.contributor.authorÖzçelik, Derya
dc.contributor.authorA?artan, Canan
dc.contributor.authorÖner, Filiz
dc.date.accessioned2024-09-25T19:44:11Z
dc.date.available2024-09-25T19:44:11Z
dc.date.issued2007
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractEpidermal Growth Factor (EGF) has been shown to improve tissue healing according to several well-design experimental studies. The possible role of EGF in tendon healing has not been defined. However, the main drawback of studies on the efficiency of EGF is to provide a long-term constant supply of EGF to target cells. In this respect, we hypothesized that the microspheres contained EGF would overcome this problem by providing a constant local supply of EGF. This study had investigated the role of EGF-loaded microspheres in a rat model for tendon heali*ng. EGF-loaded particles were prepared by double emulsion solvent evaporation method and embedded into gelatine implant. Implants containing microspheres which are equivalent to 10?g EGF (I-MS EGF10) and 2?g EGF (I-MSEGF2) were applied to Wistar albino rats. Histological and biomechanical studies were performed on to 21 days treated rats. I-MSEGF10 group showed prominent fibrosis and increased neoangiogenesis. Although, there was no major difference between I-MSEGF10 group and negative control group for the fibroblast and collagen proliferation (p>0.05), the difference for inflammation was statistically significant between same groups (p<0.05). Consequently, the approach of combining EGF and microspheres to extend the EGF release and in the same time increasing the contact time of EGF to tendon tissue was achievable. However, according to the obtained histological and biomechanical results, gelatine implants including EGF loaded microspheres were not found effective in tendon healing.en_US
dc.identifier.endpage229en_US
dc.identifier.issn1307-2080
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-40749139494en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage219en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/12694
dc.identifier.volume49en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherUniversity of Istanbulen_US
dc.relation.ispartofActa Pharmaceutica Scienciaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzYK_20240925en_US
dc.subjectEpidermal growth factoren_US
dc.subjectGelatine implanten_US
dc.subjectMicrosphereen_US
dc.subjectTendon healingen_US
dc.titlePreparation and In vivo evaluation of gelatine implants containing EGF-PLGA microspheres in tendon healingen_US
dc.typeArticleen_US

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