Irisin pathways in hearts of Type 1 diabetic adult male rats following 6 weeks of moderate and high-volume aerobic exercise on a treadmill

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dc.authorscopusid57224357578
dc.authorscopusid57196954194
dc.authorscopusid57210943925
dc.authorscopusid57219303127
dc.authorscopusid6506192760
dc.contributor.authorCelik, Humeyra
dc.contributor.authorDursun, Ali Doğan
dc.contributor.authorTatar, Yakup
dc.contributor.authorOmercioglu, Goktug
dc.contributor.authorBastug, Metin
dc.date.accessioned2024-09-25T19:44:21Z
dc.date.available2024-09-25T19:44:21Z
dc.date.issued2023
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractPurpose: Exercise-mediated protection from cardiomyopathy in diabetes through myokines raises the question of what volume of exercise should be performed. Irisin pathway molecules (consisting of peroxisome proliferator-activated receptor gamma coactivator 1-? (PGC-1?), irisin, peroxisome proliferator-activated receptors-? (PPAR-?) and uncoupling protein 1 (UCP1)), which have been shown to be mostly expressed in the heart, are thought to have beneficial effects on diabetic heart. The aim of the study is to evaluate the effects of different exercise protocols on irisin pathway in Type 1 diabetic heart. Methods: Diabetic (60 mg/kg streptozotocin i.p.) and healthy Wistar Albino rats (n = 60) were trained under moderate and high-volume exercise protocols on rat treadmill for 6 weeks. After killing, mRNA transcript and protein abundance of PGC-1?, irisin, PPAR-?, and UCP1 were determined in the left ventricles of healthy and diabetic rats. Results: PPAR-?, FNDC5, and UCP1 mRNA levels increased significantly in healthy moderate-volume exercise group (HMVE) compared to healthy high-volume exercise (HHVE) and diabetic moderate-volume exercise groups (DMVE). Moreover, protein levels of irisin and UCP1 also elevated significantly in the diabetic high-volume exercise group (DHVE) compared to the healthy control group (HC), although there was no significant difference between the groups in PPAR-?. Conclusion: Irisin and UCP1 protein values increased due to HHEV in the heart of Type 1 diabetic rats, but PPAR-? values did not change; it shows that HHEV is suitable for the heart of Type 1 diabetic rats in terms of the benefits of the pathway of irisin. © 2022, The Author(s), under exclusive licence to Springer-Verlag Italia S.r.l., part of Springer Nature.en_US
dc.description.sponsorshipAnkara University Research Funds, (15A0230006, 17L0230010); Ankara Universitesien_US
dc.identifier.doi10.1007/s11332-022-00924-1
dc.identifier.endpage605en_US
dc.identifier.issn1824-7490
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85127303722en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage597en_US
dc.identifier.urihttps://doi.org/10.1007/s11332-022-00924-1
dc.identifier.urihttps://hdl.handle.net/20.500.12491/12782
dc.identifier.volume19en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringer-Verlag Italia s.r.l.en_US
dc.relation.ispartofSport Sciences for Healthen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzYK_20240925en_US
dc.subjectDiabetic cardiomyopathyen_US
dc.subjectExercise intensityen_US
dc.subjectFNDC5en_US
dc.subjectHearten_US
dc.subjectIrisinen_US
dc.subjectType 1 diabetes mellitusen_US
dc.titleIrisin pathways in hearts of Type 1 diabetic adult male rats following 6 weeks of moderate and high-volume aerobic exercise on a treadmillen_US
dc.typeArticleen_US

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