Investigation of the effects of pinacidil and glibenclamide administration on HCN1, KCNT1, Kir 6.1, SUR1 gene expressions in hippocampus and cortex regions in epileptic rats

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dc.authorscopusid57194432176
dc.authorscopusid57219390008
dc.contributor.authorKiliç, Ümit
dc.contributor.authorSoytürk, Hayriye
dc.date.accessioned2024-09-25T19:44:12Z
dc.date.available2024-09-25T19:44:12Z
dc.date.issued2022
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractThe purpose of this study was to look into the effects of pinacidil and glibenclamide on HCN1, KCNT1, Kir 6.1, and SUR1 gene expression in epileptic rats hippocampus and cortex. Male Wistar-Albino rats were used in this study. The drugs pinacidil and glibenclamide were utilized. Control, Epilepsy, Epilepsy-O, and Epilepsy-B were the five groups formed. The epileptic focus was created by intracortical administration of penicillin at a dose of 500 IU/2 ?l. Hippocampus and Cortex are removed from all animals and Kir 6.1, SUR1, HCN1, and KCNT1 gene expression levels were determined by qPCR. The SPSS 21 program was used for statistics. HCN1 gene expression level is equal in the hippocampus and cortex (p<0.05). KCNT1, SUR1, and KIR6.1 are more expressed in the hippocampus than in the cortex (p<0.05). In epilepsy groups, HCN1 gene expression level was found to be higher than KCNT1, SUR1, and KIR6.1 gene expression levels (p<0.05). KIR6.1, SUR1, gene expression levels decreased with the application of pinacidil and glibenclamide (p<0.05). SUR1 and KIR6.1 gene expression levels were considerably lower in the epilepsy pinacidil group compared to the other groups. The gene expression levels in the hippocampus were found to be considerably higher than in the cortex group, according to this study. The fact that HCN1 gene expression levels are significantly greater in both the brain and the hippocampus 24 hours following the commencement of epileptic convulsions suggests that preventive medication may be possible. © 2022 Ondokuz Mayis Universitesi. All rights reserved.en_US
dc.description.sponsorshipAbant İzzet Baysal University Research Foundation, (2019.10.01.1408)en_US
dc.identifier.doi10.52142/omujecm.39.3.52
dc.identifier.endpage873en_US
dc.identifier.issn1309-4483
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85142021264en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage868en_US
dc.identifier.urihttps://doi.org/10.52142/omujecm.39.3.52
dc.identifier.urihttps://hdl.handle.net/20.500.12491/12716
dc.identifier.volume39en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherOndokuz Mayis Universitesien_US
dc.relation.ispartofJournal of Experimental and Clinical Medicine (Turkey)en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzYK_20240925en_US
dc.subjectepilepsyen_US
dc.subjectgene expressionsen_US
dc.subjectHCN1en_US
dc.subjectKCNT1en_US
dc.subjectKir 6.1en_US
dc.subjectSUR1en_US
dc.titleInvestigation of the effects of pinacidil and glibenclamide administration on HCN1, KCNT1, Kir 6.1, SUR1 gene expressions in hippocampus and cortex regions in epileptic ratsen_US
dc.typeArticleen_US

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