Is there a nephropathy risk for children with asthma who use inhaled steroids?

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dc.authorscopusid55624890100
dc.authorscopusid10039968300
dc.authorscopusid6603098626
dc.authorscopusid6504095729
dc.authorscopusid26642917900
dc.contributor.authorBekdas, Mervan
dc.contributor.authorTosun, Mehmet
dc.contributor.authorDemircioglu, Fatih
dc.contributor.authorGoksugur, Sevil Bilir
dc.contributor.authorKismet, Erol
dc.date.accessioned2024-09-25T19:43:04Z
dc.date.available2024-09-25T19:43:04Z
dc.date.issued2013
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractBackground and aim: Asthma is one of the most common chronic inflammatory diseases in children, but whether these patients, who require long-term follow-up and medication, carry a risk for nephropathy is still unknown. The purpose of this study was to investigate whether the urinary microalbumin level and urinary microalbumin/creatinine ratio, early indicators of nephropathy, increase in children with asthma. Material and methods: Asthmatic children aged 10 years or older who had been on medication for at least 4.2 ± 2.7 years were selected for this study. All patient medical histories, physical examination results, and serum amyloid A (SAA), urinary microalbumin, and urinary creatinine measurements were evaluated. Results: Twenty-one children with asthma (13 boys, eight girls) were evaluated, including 12 medication-controlled cases (57.1%) and nine cases admitted during an acute attack (42.8%). SAA levels in the acute attack cases (0.16 ± 0.06 vs. 3.5 ± 7.8 mg/dl, p < 0.001) were significantly higher than those in medically controlled cases. Urinary microalbumin was not significantly different between groups, although it was higher during acute attacks (15 ± 19 vs. 22.6 ± 35.2 mg/l). Ten of the patients with asthma (47.6%) had been on medication for <5 years, and 11 (52.3%) for ?5 years. The urinary microalbumin levels (8.2 ± 4.8 vs. 27.5 ± 34.6 mg/l, p = 0.02) and urinary microalbumin/creatinine ratios (0.06 ± 0.02 vs. 0.14 ± 0.11, p = 0.016) were significantly higher in those receiving medication for ?5 years compared with those receiving medication for <5 years. Conclusions: SAA levels increased in patients suffering from acute asthma attack. The urinary microalbumin levels and urinary microalbumin/creatinine ratios of children with asthma who had received a long-term inhaled steroid were significantly higher than those of children who had not.en_US
dc.identifier.endpage651en_US
dc.identifier.issn0393-6384
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-84896733591en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage647en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/12410
dc.identifier.volume29en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherActa Medica Mediterraneaen_US
dc.relation.ispartofActa Medica Mediterraneaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzYK_20240925en_US
dc.subjectAsthmaen_US
dc.subjectChilden_US
dc.subjectNephropathyen_US
dc.subjectUrinary microalbuminen_US
dc.titleIs there a nephropathy risk for children with asthma who use inhaled steroids?en_US
dc.typeArticleen_US

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