Down's Syndrome Screening Markers and HLA-G to Determine High-risk Pregnancies

High risk pregnancy defines pregnancies that affects mother or fetus, and experience one or more health problems. Pre-eclampsia, intrauterine growth retardation, preterm labor, preterm premature rupture of membranes is the leading cause of fetal morbidity and mortality. Preeclampsia is still continuing actuality as the most common risk increasing factor on maternal and fetal morbidity and mortality in high-risk pregnancies. Especially, in recent years, steps have been taken to identify high-risk pregnancies during the first trimester. Among the molecules studied in soluble HLA-G associated with defect in placental trophoblast invasion, pregnancy-associated plasma protein A, free beta human chorionic gonadotrophin, alpha feto-protein, inhibin, estriol are included. In the case of detection of high risk pregnancies in the first trimester, closer monitoring will be provided and strategies for preventing pregnancy complications will be improved.