Comparison of Costs and Efficacy of Intravenous and Orally Disintegrating Ondansetron Tablet as a Prophylactic Antiemetic Therapy in Major Gynecologic Operations

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dc.contributor.authorDemiraran, Yavuz
dc.contributor.authorOzdemir, Ismail
dc.contributor.authorKocaman, Buket
dc.contributor.authorHayit, Feray
dc.contributor.authorDemirci, Fuat
dc.date.accessioned2024-09-25T19:56:20Z
dc.date.available2024-09-25T19:56:20Z
dc.date.issued2005
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractObjective: The aim of the study is to compare the antiemetic efficacy and costs of oral rapid disintegrating ondansetron tablets and intravenously administered ondansetron in patients undergoing major gynecologic surgery. Materials and Methods: Anesthesia was induced with thiopenthone, vecuronium and fentanyl. Nitrous oxide and sevoflurane were used to maintain anesthesia. Patients were prospectively randomized into three groups of 30 patients each, receiving either ondansetron 8 mg intravenously or saline infusion only or oral rapid disintegrating tablets of 8 mg ondansetron. The patients were evaluated for nausea and vomiting at 1st, 5th, 10th, 20th, 30th, 60th, and 120th minutes and 6th hours postoperatively. Results: There were no significant differences in adverse effects between placebo group, intravenous ondansetron group and oral ondansetron group (P>0.05). The incidence rates of nausea, vomiting and the need of metoclopropamide were higher in placebo group than intravenous and oral ondansetron groups (P<0.05). Conclusion: Postoperative nausea and vomiting are common during recovery from general anesthesia. Both oral and intravenous forms of ondansetron are efficacious in the prevention of this postoperative nausea and vomiting. Orally disintegrating tablets are inexpensive and may be administered more easily than the intravenous form of ondansetron. Therefore, oral ondansetron tablet may be an alternative to intravenous ondansetron infusion for postoperative nausea and vomiting after major gynecologic operations.en_US
dc.identifier.endpage138en_US
dc.identifier.issn1309-0399
dc.identifier.issn1309-0380
dc.identifier.issue2en_US
dc.identifier.startpage134en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/13226
dc.identifier.volume6en_US
dc.identifier.wosWOS:000420558400010en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherGalenos Yayinciliken_US
dc.relation.ispartofJournal of The Turkish-German Gynecological Associationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzYK_20240925en_US
dc.subjectanesthesiaen_US
dc.subjectgynecologic surgeryen_US
dc.subjectpostoperative nausea and vomitingen_US
dc.subjectondansetronen_US
dc.titleComparison of Costs and Efficacy of Intravenous and Orally Disintegrating Ondansetron Tablet as a Prophylactic Antiemetic Therapy in Major Gynecologic Operationsen_US
dc.typeArticleen_US

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